A5101741752- Rheumatoid Arthritis Research and Therapies
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Peripheral Nerve Disorders
- Systemic Lupus Erythematosus Research
- Tendon Structure and Treatment
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Immunology Research
- Spine and Intervertebral Disc Pathology
- Nerve injury and regeneration
- Medical and Biological Sciences
- Peripheral Neuropathies and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Cytokine Signaling Pathways and Interactions
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Bone and Joint Diseases
- Shoulder and Clavicle Injuries
- Muscle Physiology and Disorders
- Congenital limb and hand anomalies
- Foot and Ankle Surgery
- Dupuytren's Contracture and Treatments
- Osteoarthritis Treatment and Mechanisms
Kyoto Prefectural University of Medicine
2015-2025
Kyoto Prefectural University
2014
Background: The prevalence and clinical characteristics of osteochondritis dissecans (OCD) the humeral capitellum among adolescent baseball players are unknown. Purpose: To determine OCD in competitive to investigate these patients. Study Design: Cross-sectional case-control study; Level evidence, 3. Methods: A total 2433 (mean age, 14.5 ± 1.5 years) belonging junior high school clubs were enrolled. Players completed a questionnaire, elbow each player’s throwing arm was assessed by...
Abstract Purpose To evaluate the sensitivity of diffusion tensor imaging (DTI) in assessing peripheral nerve regeneration vivo. We assessed changes DTI parameters and histological analyses after injury to examine degeneration rat sciatic nerves. Materials Methods For magnetic resonance (MRI), 16 rats were randomly divided into two groups: group P (permanently crushed; n = 7) T (temporally 9). Serial MRI right leg was performed before operation, then at timepoints 1, 2, 3, 4 weeks crush...
Bone morphogenetic protein-7 (BMP-7) promotes not only osteogenesis but also matrix production in chondrocytes and tenocytes. However, because of its short half-life, maintaining local concentrations BMP-7 is difficult. We examined the use a gelatin hydrogel sheet (GHS) for sustained release stimulating rotator cuff repair at tendon-to-bone insertion. Twelve-week-old male Sprague-Dawley rats were used. Radiolabeled ((125)I-BMP-7) was injected into subacromial bursa (125)I-BMP-7 group,...
Abstract The objective of the present study was to determine whether expression connexin 43 (Cx43) effected on inflammatory conditions in rat fibroblast‐like synoviocytes (FLS) and model rheumatoid arthritis (RA). Cx43 FLS stimulated with lipopolysaccharide (LPS) confirmed by real‐time reverse transcriptase polymerase chain reaction (RT‐PCR). effects small‐interfering RNA targeting (siCx43) pro‐inflammatory cytokines chemokine were assessed RT‐PCR enzyme‐linked immunosorbent assay (ELISA)....
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes, including proliferation, migration, and angiogenesis, through interaction with family of five G protein-coupled receptors (S1P1-5). Some reports have implicated S1P as an important inflammatory mediator the pathogenesis airway inflammation, but role S1P3 lung diseases not completely understood. We used S1P3-deficient (knockout (KO)) mice to clarify receptor signaling pulmonary...
The bone is a metabolically active organ which undergoes repeated remodeling cycles of resorption and formation. In this study, we revealed robust extremely long-lasting circadian rhythm in ex vivo culture maintained for over six months from the femoral PERIOD2Luciferase mouse. Furthermore, also identified clocks flat bones. High- or low-magnification real-time bioluminescence microscopic imaging that rhythms emanated articular cartilage epiphyseal within growth plate juvenile animals....
Objective Synovial fluid pH is decreased in patients with rheumatoid arthritis (RA); however, the underlying mechanisms are unclear. We undertook this study to examine mechanism by which synovial regulated and explore possibility of a therapeutic strategy manipulating mechanism. Methods determined lactate concentration from 16 RA patients. Cultured fibroblasts (SFs) inflamed joints 9 (RASFs) were examined for expression ion transporters that regulate intracellular extracellular pH. The...
Abstract Glucocorticoids improve the symptoms of peripheral nerve disorders, such as carpal tunnel syndrome and neuropathy. The effects glucocorticoids are mainly anti‐inflammatory, but mechanisms their in disorders remain unclear. Schwann cells nerves express glucocorticoid receptors (GR), enhance rate myelin formation vitro . Therefore, it is possible that clinical improvement by due, at least part, to modulation myelination. In this study, an adrenalectomy (ADX) was performed, followed a...
Abstract The circadian clock contains genes including Bmal1 and Period2 it maintains an interval rhythm of approximately 24 hours (the rhythm) in various organs growth plate articular cartilage. As endochondral ossification is involved not only but also fracture healing, we investigated the functions sites undergoing healing. Our models using external fixation femurs Period2::Luciferase knock-in mice which enables monitoring endogenous state via bioluminescence. Organ culture was performed...
The coronavirus disease 2019 (COVID-19) pandemic restricted the activities of general population and affected health systems, which adapted medical resources to manage COVID-19 treatment. During initial lockdown, trauma volumes decreased. However, it is unknown whether changed from 2021 2022, late period when vaccination began restrictions were gradually lifted. first objective this study was investigate changes in number types period, compared with 2018 2019, pre-pandemic period. second...
Raman spectroscopy can be used for analysis of objects by detecting the vibrational spectrum using label-free methods. This imaging method was applied to peripheral nerve regeneration examining sciatic in vitro and vivo. spectra intact tissue had three particularly important peaks range 2800−3000 cm −1 . Spectra injured nerves showed significant changes ratio these peaks. Analysis cellular suggested that reflects axon myelin components this tissue. Immunohistochemical number axons myelinated...
Treatments for rheumatoid arthritis (RA) have improved since methotrexate and biological agents were approved; however, few longitudinal analyses tracked joint destruction, deformity progression, or functional impairments that directly affect the activities of daily living. Due to consequences impairments, we conducted this study glean more information regarding progression over time.This enrolled 134 hands in 67 RA patients with hand deformities 2004. After 5 years, 100 52 eligible final...
The circadian clock governs endogenous day-night variations. In bone, the metabolism and growth show diurnal rhythms. is based on a transcription-translation feedback loop composed of genes including Period2 (Per2), which encodes protein period homolog 2. Because plasma parathyroid hormone (PTH) levels variation, we hypothesized that PTH could carry time information to bone cartilage. this study, analyzed effect femur.Per2::Luciferase (Per2::Luc) knock-in mice were used their femurs...
The sacroiliac joint is an important source of low back pain and may be influenced by pathologies in adjoining structures such as the hip or spine. This study aimed to investigate influence osteoarthritis on degeneration examining joints patients, focusing localization quantity vacuum phenomena.The preoperative computed tomography (CT) 31 female replacement candidates (mean age 69.1) pelvic CT 34 age-matched controls 67.9) were used reconstruct three-dimensionally. score axial view, well...
Abstract Background Postoperative surgical site infections (SSIs) are an important complication to prevent in treatment. Patients with diabetes mellitus (DM) have a higher risk of SSIs. Preoperative glycemic control is required. For patients orthopedic trauma, the duration preoperative limited because delaying operative treatment difficult. However, whether would decrease SSIs diabetic lower extremity fractures unclear. The first aim this study was investigate rate among DM who had undergone...
We investigated the effects of stress-shielding on both viscoelastic properties and microstructure collagen fibers in Achilles tendon by proton double-quantum filtered ((1) H-DQF) NMR spectroscopy. The right hind-limbs 20 Japanese white rabbits were immobilized for 4 weeks a cast with ankle plantarflexion. Dynamic viscoelasticity tendons was measured using spectrometer. Proton DQF signals analyzed to determine residual dipolar coupling bound water molecules tendons. Both dynamic storage...
Abstract Background It is important to evaluate dynamic changes in the joint space width of ankle mortise detail order better understand pathology foot and disorders. However, there are few reports on assessed using 3D images. The purpose this study was determine (tibiotalar joint) association with dorsiflexion plantar flexion healthy feet. Methods Computed tomography (CT) images 10 feet were obtained neutral, plantarflexed dorsiflexed positions joint, from which virtual models fabricated...