A5003831437- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Paraoxonase enzyme and polymorphisms
- Hormonal Regulation and Hypertension
- Intestinal and Peritoneal Adhesions
- Parkinson's Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Neuroscience of respiration and sleep
Akdeniz University
2013-2023
Biruni University
2019
The aim of the present study was to investigate gastroprotective effect apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS F13A. APJ receptor antagonist administered determine influence stress-induced injury. for 6 h resulted in development mucosal lesions accompanied by a significant increase plasma corticosterone. increased concentration 4-hydroxynonenol (4-HNE) malondialdehyde (MDA)...
Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known stimulate release of corticotropin-releasing factor (CRF) via receptor. We tested the hypothesis that stress-induced gastrointestinal (GI) dysfunction mediated by central apelin. also assessed effect exogenous on GI motility under nonstressed (NS) conditions conscious rats. Prior solid gastric emptying (GE) and colon transit (CT)...
Apelin, the endogenous ligand of G protein-coupled receptor (APJ), plays an important role in physiological response to homeostatic perturbations. The aim present study was investigate effect apelin on functions peritoneal macrophages. A double staining immunofluorescence technique used determine expression APJ Rat macrophages were randomly divided into three groups: control, and apelin+F13A. significant decrease phagocytic chemotactic activity resulted when incubated with [Pry(1)]-Apelin-13...
The objective of this study was to explore the role apelin in healing gastric lesions induced by stress. Male Wistar rats were exposed water immersion and restraint stress (WIRS) for 6 h with or without receptor antagonist F13A. killed on 1st, 3rd, 5th 10th day after end induction. Apelin hypoxia-inducible factor-1α expression increased 1st exposure decreased daily thereafter. However, F13A retarded preventing improvement mucosal blood flow, prostaglandin E2 production vascular endothelial...
Apelin is a peptide that plays role in physiological processes such as angiogenesis, apoptosis, and proliferation. The aim of this study was to investigate the capsaicin-sensitive afferent neurons vagus effect apelin against ischemia/reperfusion (I/R) injury. experimental groups were (1) control, (2) I/R, (3) + (4) vagotomy (5) (6) capsaicin (7) (8) lorglumide (9) I/R. To test potential gastroprotective apelin-13, apelin-13 (2 mg/kg i.v.) administered just before both ischemia reperfusion. A...
The purpose of this study was to detect gastric changes in Parkinson’s disease induced by 1-methyl-4-phenyl-1.2.3.6.-tetrahydropyridine (MPTP), and investigate the protective effect docosahexaenoic acid (DHA) against these mice. mice were divided into 4 groups (n=10 per group) as control, DHA, Parkinson DHA+Parkinson groups. DHA administered gavage for 30 days. On 23rd day treatment, animals intraperitoneally injected with MPTP. Seven days after injection MPTP, their locomotor activity,...
Objective: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor (APJ), has a wide range roles in physiological pathophysiological processes tissues. effects increased APJ as an indicator damage inflammatory conditions or compensatory mechanism are not fully clear bowel disease (IBD). This study was designed to assess role 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Methods: Colitis adult male Wistar rats were induced by intrarectally...
Stress plays a major role in functional gastrointestinal (GI) disorders. GI symptoms may develop as result of accumulation stressors some individuals while others can adapt to stressors. Exposure repeated experience with the same stressor produce an adaptation behavioral and hypothalamic‐pituitary‐adrenal (HPA) axis response. However, mechanism remains unclear. Acute restraint stress (ARS) increases corticotrophin releasing factor (CRF) hypothalamic paraventricular nucleus (PVN) leads...