Eicosanoids derived from omega-6 (n6) polyunsaturated fatty acids (PUFAs) have proinflammatory functions whereas eicosanoids omega-3 (n3) PUFAs anti-inflammatory properties. This study was designed to evaluate the effect of insulin analog initiation therapy on n6 and n3 in type 2 diabetic patients during early phase. Sixteen with glycosylated hemoglobin (HbA1c) levels above 10% despite ongoing combination sulphonylurea metformin were selected. Former treatment regimen continued for first day...

Background: Skeletal development and the incidence of skeletal deformities in fish are among most important problems that need to be solved increase success aquaculture. reduce survival, growth nutrition fish. Objective: In this study, deformations were investigated juvenile Oncorhynchus mykiss, widely farmed trout Turkey. Methods:Thirty farms visited 1200 individuals collected analysed. order determine samples, observed divided into groups. The common pathological findings also evaluated....

Oxidative stress and excessive nitric oxide production via induction of inducible synthase (NOS)-2 have been shown in the pathogenesis liver ischemia–reperfusion (IR) injury. Neutral sphingomyelinase (N-SMase)/ceramide pathway can regulate NOS2 expression therefore this study determined role selective N-SMase inhibition on nitrative oxidative markers following IR Selective inhibitor was administered intraperitoneal injections. Liver injury created by clamping blood vessels supplying median...

Previous studies have revealed the activation of neutral sphingomyelinase (N-SMase)/ceramide pathway in hepatic tissue following warm liver ischemia reperfusion (IR) injury. Excessive ceramide accumulation is known to potentiate apoptotic stimuli and a link between apoptosis endoplasmic reticulum (ER) stress has been established IR Thus, this study determined role selective N-SMase inhibition on ER markers rat model Selective inhibitor was administered via intraperitoneal injections. Liver...

This study was designed to investigate the effects of starvation and re-feeding cycles on growth performance body chemical composition Oncorhynchus mykiss juveniles. A total 360 juveniles with initial mean weights (IW) 8.46 ± 0.07 g (n = 360) were stocked into 400-L tanks in triplicate for each group, 30 per tanks. The control group received regular feed, as is common practice. three other groups periodically starved: 1 day followed by 6 days (S1), 2 5 (S2) 3 4 (S3). experiment lasted 10...

Limited data are available on the serum levels of different sphingomyelin (CerPCho) and ceramide (CER) species in sickle-cell disease (SCD). This study was aimed at identifying C16-C24 CerPCho CER obtained from SCD patients controls. Circulating neutral sphingomyelinase (N-SMase) activity, ceramide-1-phosphate (C1P), sphingosine-1-phosphate (S1P) were also determined. Blood collected 35 hemoglobin (Hb)A volunteers 45 homozygous HbSS patients. Serum determined by an optimized multiple...

This study aimed to determine early postoperative changes of plasma polyunsaturated fatty acids (PUFAs) following laparoscopic sleeve gastrectomy (LSG). Ten obese patients (mean BMI: 51.10 ± 11.59 kg/m2) underwent LSG and eleven normal weight control 24.37 2.33 abdominal surgery. Fasting blood samples were collected prior surgery, at day 1 after surgery postoperation oral feeding. Plasma levels arachidonic acid (AA, C20:4n6), dihomo-gamma-linolenic (DGLA, C20:3n6), eicosapentaenoic (EPA,...

The aim of the present study was to assess omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) in liver tissue evaluate changes n‑6-associated inflammatory pathway following ischemia/re‑perfusion (IR) injury. Male Wistar rats which were allowed free access standard rat chow included study. Blood vessels supplying median left lateral hepatic lobes occluded with an arterial clamp for 60 min, followed by min re‑perfusion. Levels arachidonic acid (AA, C20:4n‑6),...

Fungal diseases of fish have become increasingly important, over the past 20 years. The traditional ‘‘fungi’’ are comprised members from several different taxonomic kingdoms. An increasing number other environmental fungi being reported diseased fish, further testament to opportunistic nature many fungi. Active fungal agents living in waters cause infections juvenile and adult individuals populations, leading decay eggs larvae. that generally observed as a secondary infection populations...

This study aimed to investigate LDL subfraction distribution as well serum cholesteryl ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), and paraoxonase (PON1) activity in streptozotocin-induced diabetic guinea pigs. Materials/Methods . Guinea pigs were given a single intraperitoneal (ip) injection of streptozotocin (STZ) animals having fasting blood glucose levels greater than 200 mg/dl, considered diabetic. Protein LCAT CETP determined via ELISA. Paraoxonase was...

Sodium metabisulfite is commonly used as preservative in foods but can oxidize to sulfite radicals initiating molecular oxidation. Ghrelin a peptide hormone primarily produced the stomach and has anti-inflammatory effects many organs. This study aimed assess endogenous omega-3 (n-3) omega-6 (n-6) polyunsaturated fatty acids (PUFAs) rat peripheral organs following sodium treatment determine possible effect of ghrelin on changes n-6 inflammatory pathway.Male Wistar rats included were allowed...

This study was conducted to determine the fish consumption habits in Diyarbakır province and reasons that influence these habits. A questionnaire survey carried out on a total of 3310 individuals, consisting 1910 males 1400 females, center districts Diyarbakır. According results, it found 16% respondents consumed most preferred were anchovy (30.81%) carp (25.98%). When buying fish, 40.04% people said they be cheap 20.63% tasty. The concluded majority occurs during winter season. primary for...

The aim of this study was to evaluate hepatic polyunsaturated fatty acids (PUFAs) and inflammatory response in an animal cell model endoplasmic reticulum (ER) stress. Rats were divided into control, tunicamycin (TM)-treated, TM + tauroursodeoxycholic acid (TUDCA)-treated groups. Hepatic ER stress induced by the inhibitor TUDCA injected 30 min before induction Liver THLE-3 cells treated with administered advance decrease cytotoxic effects. Necroinflammation evaluated liver sections, while...

The 8-hydroxy-2′-deoxyguanosine (8-OHdG) damages are base induced by reactive oxygen species. We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation repair activation quantitating DNA damage using Aklides.NUK system.The data demonstrated that loss resulted increased oxidative its overexpression contributes removal menadione-induced even under stress conditions. Moreover, 8-oxoguanine glycosylase-1 (OGG1) expression level positively correlates expression. Also...

In this study, the effects of different vegetable oil sources on growth and body chemical composition white seabream (Diplodus sargus) juveniles were investigated.Four isonitrogenous (36%) isolipidic (16%) experimental diets formulated containing fish (FO) soybean (SO), canola (CO) hazelnut (HO).Each diet was fed to triplicate groups 30 (initial mean weight 6 gram) for eight weeks.At end final specific rate found significantly among (P<0.05).HO CO had better when compared with other...

20-Hydroxyeicosatetraenoicacid (20-HETE) is an important mediator that regulates vascular tone and blood pressure (BP). Although various experimental animal hypertension models demonstrated 20-HETE contributes to increased resistance BP, these effects have not been studied in Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced model. In this study, we investigated the of on responsiveness BP L-NAME-induced hypertension.Wistar Albino rats were used study. Hypertension was induced...