A5050995173- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Curcumin's Biomedical Applications
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Inhalation and Respiratory Drug Delivery
- 3D Printing in Biomedical Research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Drug Solubulity and Delivery Systems
- Immune Response and Inflammation
- Protease and Inhibitor Mechanisms
- Photodynamic Therapy Research Studies
- Polymer Surface Interaction Studies
Temple University
2020-2024
University of Minnesota
2014-2023
Philadelphia University
2022-2023
Fox Chase Cancer Center
2022-2023
GTx (United States)
2020
University of Minnesota Medical Center
2013-2019
Masonic Cancer Center
2008-2018
Minneapolis Institute of Arts
2018
Cancer Research Center
2017
Hormel (United States)
2017
The endo-lysosomal escape of drug carriers is crucial to enhancing the efficacy their macromolecular payload, especially payloads that are susceptible lysosomal degradation. Current vectors enable macromolecules such as DNA limited by toxicity and ability carry only classes therapeutic agents. In this paper, we report rapid (<10 min) biodegradable nanoparticles (NPs) formulated from copolymers poly(DL-lactide-co-glycolide) (PLGA). mechanism selective reversal surface charge NPs (from anionic...
Efficient cytoplasmic delivery of therapeutic agents is especially important for drugs with an intracellular site action elicitation a maximal effect. In this study, we demonstrate the efficacy biodegradable nanoparticles dexamethasone, glucocorticoid, whose intracellular. Equal doses two formulations drug-loaded releasing different encapsulated drug were tested antiproliferative activity in vascular smooth muscle cells. The was significantly greater and sustained that released higher dose...
The oral absorption of drugs that have poor bioavailability can be enhanced by encapsulation in polymeric nanoparticles. Transcellular transport nanoparticle-encapsulated drug, possibly through transcytosis, is likely the major mechanism which nanoparticles improve drug absorption. We hypothesized cellular uptake and further increased targeting folate receptors expressed on intestinal epithelial cells. objective this research was to study effect folic acid functionalization transcellular...
Flash nanoprecipitation (FNP) is a process that, through rapid mixing, stabilizes an insoluble low molecular weight compound in nanosized, polymer-stabilized delivery vehicle. The polymeric components are typically amphiphilic diblock copolymers (BCPs). In order to fully exploit the potential of FNP, factors affecting particle structure, size, and stability must be understood. Here we show that polymer type, hydrophobicity crystallinity small molecule, molecule loading levels all affect size...