A5011192385- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- T-cell and Retrovirus Studies
- Calcium signaling and nucleotide metabolism
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Retinoids in leukemia and cellular processes
- Hedgehog Signaling Pathway Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- Tryptophan and brain disorders
Paracelsus Medical University
2011-2022
Unfallkrankenhaus Salzburg
2022
Institute of Molecular Biotechnology
2013
University of Salzburg
2010-2012
Weizmann Institute of Science
2012
Hebrew University of Jerusalem
2012
Abstract Peripheral immune cell infiltration into the brain is a prominent feature in aging and various neurodegenerative diseases such as Alzheimer’s disease (AD). As AD progresses, CD8+ T cells infiltrate parenchyma, where they tightly associate with neurons microglia. The functional properties of are largely unknown. To gain further insights putative functions brain, we explored compared transcriptomic profile isolated from blood transgenic (APPswe/PSEN1dE9, line 85 [APP-PS1]) age-matched...
AbstractChronic lymphocytic leukemia (CLL) has an incidence 4/100 000 people in the western world and is one of first cancers reported to be associated with deregulated miRNA expression. microRNAs are small non coding RNAs that important regulators protein expression through binding their untranslated 3'-UTR region. The miR-34 family was demonstrated induced by tumor suppressor p53 elicit p53-like responses like senescence, cell cycle arrest apoptosis depending on type. We have shown a...
Chronic lymphocytic leukemia (CLL) pathophysiology is characterized by a complex crosstalk of tumor cells with the microenvironment. In this regard, NF-κB signaling considered as important axis, variety key molecules aberrantly expressed or genetically altered in patients CLL. One these BIRC3 (cIAP2), central regulator noncanonical that serves pathway brake absence microenvironmental signals. However, contribution expression to CLL progression and potential therapeutic implications...
Abstract Microenvironmental interactions are crucial for the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. CD4+ T cells that express CD40 ligand (CD40L), along with other accessory immune stromal within CLL lymph nodes, provide signals needed activation outgrowth tumor clone. Furthermore, correct positioning lymphoid subcompartments is essential transmission these supportive signals. Thereby, interstitial cell migration adhesion events, influenced by activational...
The TCL1 mouse model is widely used to study pathophysiology, clonal evolution, and drug sensitivity or resistance of chronic lymphocytic leukemia (CLL). By performing whole exome sequencing, we present the genetic landscape primary tumors from mice serially transplanted into wild-type recipients mimic evolution. We show that similar CLL patients, mutations in are frequently subclonal heterogenous among different mice. further describe this molecular heterogeneity mirrors disease...
Chronic lymphocytic leukemia (CLL) is a heterogenous disease that highly dependent on cross talk of CLL cells with the microenvironment, in particular T cells. derived from patients or murine models are skewed to an antigen-experienced T-cell subset, indicating certain degree antitumor recognition, but they also exhausted, preventing effective immune response. Here we describe novel mechanism tumor evasion independent exhaustion, using B-cell-specific deletion transcription factor IRF4...
// Sylvia Ganghammer 1,2,* , Evelyn Hutterer Elisabeth Hinterseer Gabriele Brachtl 1,2 Daniela Asslaber Peter William Krenn Tamara Girbl Petra Berghammer Roland Geisberger Alexander Egle Antonella Zucchetto 3 Anna Kruschinski 4 Valter Gattei Alexandre Chigaev 5 Richard Greil Tanja Nicole Hartmann 1 Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Hematology, Oncology, Hemostaseology, Infectious Diseases Rheumatology, Oncologic Center, Paracelsus...
The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For majority solid tumors, a assessment, which is based on imaging, used guide these decisions. However, measuring serum protein biomarkers (i.e. markers) may be additional use. Furthermore, markers exhibit variable specificity sensitivity cannot therefore solely relied upon making regarding treatment. Therefore, there requirement for identification...
Abstract The proliferation of chronic lymphocytic leukemia (CLL) cells requires communication with the lymphoid organ microenvironment. Integrin-linked kinase (ILK) is a multifunctional intracellular adaptor protein that transmits extracellular signals to regulate malignant cell motility, metastasis, and cell-cycle progression, but poorly characterized in hematologic malignancies. In this study, we investigated role ILK context CLL observed high expression patient samples, particularly tumor...
// Nadja Zaborsky 1, 2 , Franz Josef Gassner Daniela Asslaber Petra Reinthaler Ursula Denk Sabine Flenady Josefina Piñón Hofbauer Barbara Danner Stefan Rebhandl Andrea Harrer 3 Roland Geisberger Richard Greil Alexander Egle 1 Laboratory for Immunological and Molecular Cancer Research, Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology Rheumatology, Oncologic Center, Paracelsus University, Salzburg, Austria Salzburg Research Institute,...
miRNAs are small-noncoding RNA molecules that regulate gene expression on a posttranscriptional level. A number of oncogenes and tumor suppressors were found to be targets global miRNA signatures able distinguish between cancerous non-cancerous tissues. Therefore it was not surprising some could linked the pathogenesis cancer. In this review we provide an overview use microRNAs as diagnostic prognostic tools in cancer focus biomarker for disease activity.