Joseph Peacock
A5000612552- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Neonatal and fetal brain pathology
- Global Maternal and Child Health
- Streptococcal Infections and Treatments
- Diet and metabolism studies
- Renal function and acid-base balance
- Herpesvirus Infections and Treatments
- Child Nutrition and Water Access
- Bacterial Infections and Vaccines
- Kidney Stones and Urolithiasis Treatments
- Cancer, Hypoxia, and Metabolism
- Parvovirus B19 Infection Studies
- Vaccine Coverage and Hesitancy
- Cytomegalovirus and herpesvirus research
- Antibiotic Use and Resistance
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Urology and Nephrology Studies
- Blood donation and transfusion practices
- Infant Development and Preterm Care
- Hepatitis B Virus Studies
- Biochemical effects in animals
- HIV/AIDS Research and Interventions
St George's, University of London
2024
Institute of Infection and Immunity
2024
Edge Hill University
2021
Worthing Hospital
2018
Abstract Background Epidemiological evidence about the etiology and antimicrobial resistance of neonatal infections remains limited in low-resource settings. We aimed to describe a prospective observational cohort study conducted at two hospital sites Kampala, Uganda. Methods Babies admitted either unit with risk factors or signs sepsis, pneumonia, meningitis had blood culture, nasopharyngeal swab, lumbar puncture (if indicated) collected. Basic demographics were collected, babies followed...
Abstract Background Child survival rates have improved globally, but neonatal mortality due to infections, such as group B Streptococcus (GBS), remains a significant concern. The global burden of GBS-related morbidity and is substantial. However, data from low middle-income countries lacking. Vaccination during pregnancy could be feasible strategy address disease burden. Methods We assessed maternal rectovaginal GBS colonization in prospective cohort 6062 women-infant pairs. Surveillance for...
To compare the bicarbonate kinetics and gastrointestinal (GI) symptom responses between an equal dose of sodium citrate using delayed-release capsules. Thirteen active males (age 20.5 ± 2.1 y, height 1.8 0.1 m body mass [BM] 76.5 9.6 kg) consumed either 0.3 g.kg−1 BM bicarbonate, or a placebo, double-blind, randomized crossover design. Blood ion (HCO3−) concentration, pH GI symptoms were measured pre-consumption every 10 min for 180 post-consumption. HCO3− concentration (P < 0.001) = 0.040)...
Abstract Background Maternal primary cytomegalovirus (CMV) infection is associated with abortion and congenital anomalies. In Uganda, the burden of maternal CMV not well studied. This study thus assessed seroprevalence factors among pregnant women at Kawempe National Referral Hospital in Kampala. work forms a part PROGRESS study, an observational cohort undertaken Kampala, between November 2018 April 2021. Methods We conducted cross-sectional September 2020 January 2021 639 admitted to labor...
Abstract Background Low- and middle-income countries lack data on culture-confirmed sepsis in HIV-exposed infants, despite the reported heightened risk of infectious morbidity. This study describes antibiotic resistance patterns among children a large etiological cohort Kampala, Uganda. Methods was prospective birth based at 2 Ugandan sites, as part Progressing Group B Streptococcal Vaccines (PROGRESS) study. Any infant with factors, signs, or symptoms infection presenting before 3 months...
Abstract Background Group B streptococcal (GBS) sepsis during infancy is a leading cause of child mortality and an important contributor to long-term neurodisability. Data on outcomes among invasive GBS infection survivors in low- middle-income countries are limited. We present 2-year neurodevelopment growth after Uganda. Methods Participants were infants with culture-proven &lt;3 months age gestationally matched comparison cohort who did not have Kampala, Neurodevelopmental impairment...
Abstract Introduction Maternal Group B Streptococcus (GBS) rectovaginal colonization is an important risk factor for invasive disease in neonates, yet availability of culture-based methods detection limited low-resource settings. We evaluated the diagnostic performance HiberGene (HG) GBS loop-mediated isothermal amplification (LAMP) assay rapid rectal/vaginal swabs collected from women Uganda. This work forms a part PROGRESS study. Methods In phase 1, 1294 rectal and vaginal were pregnant...
Abstract Background We investigated awareness of neonatal infections among a population pregnant women and other community members in Kampala, Uganda. explored perceived causes perceptions appropriate treatments. Methods conducted focus group discussions (FGDs) in-depth interviews (IDIs) with 97 participants: 25 leaders who took part 3 FGDs, 12 IDIs, 60 8 between November 2019 October 2020. Data were analyzed thematically. This work formed the PROGRESS study, an observational cohort study...
Abstract Background Hepatitis B virus (HBV) infection is a significant cause of morbidity and mortality globally. The World Health Organization estimates that just 10.5% individuals living with HBV globally are aware their status. Antenatal care provides an opportunity to screen pregnant women for treat those who eligible reduce the risk vertical transmission. We conducted observational study determine proportion active delivering at government-funded hospital in Kampala, Uganda, estimate...
Abstract Background Every year an estimated 2–3 million babies are stillborn, with a high burden in Africa. Infection is important driver of stillbirth. There lack data on the bacterial causes stillbirth Uganda, contributing to interventions such as effective prophylaxis and development maternal vaccine options against most implicated pathogens. Methods The PROGRESS study was observational cohort undertaken Kampala, between November 2018 April 2021. If woman delivered stillborn baby, consent...
e15538 Background: The accepted gold standard for carboplatin dose calculation is the Calvert formula: Dose = (GFR + 25) x AUC. GFR (glomerular filtration rate) commonly made with formulae such as CG, which are based on serum creatinine. Cr51-EDTA, a radionuclide scan, also can be used to calculate and more accurate closest estimation inulin clearance (gold GFR). impact of factors body mass index (BMI), muscle albumin upon accuracy CG versus EDTA not well-defined. Many international clinical...