A5090407540- Ophthalmology and Eye Disorders
- Facial Trauma and Fracture Management
- Ocular Disorders and Treatments
- Facial Rejuvenation and Surgery Techniques
- Nasolacrimal Duct Obstruction Treatments
- Traumatic Ocular and Foreign Body Injuries
- Head and Neck Surgical Oncology
- Cancer and Skin Lesions
- Sinusitis and nasal conditions
- IgG4-Related and Inflammatory Diseases
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- Reconstructive Facial Surgery Techniques
- Glaucoma and retinal disorders
- Facial Nerve Paralysis Treatment and Research
- Nonmelanoma Skin Cancer Studies
- Ocular Oncology and Treatments
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Vasculitis and related conditions
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune and Inflammatory Disorders
- Corneal Surgery and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Lymphoma Diagnosis and Treatment
Massachusetts Eye and Ear Infirmary
2016-2025
Harvard University
2016-2025
Vancouver Coastal Health
2022-2025
University of British Columbia
2022-2025
Vancouver Coastal Health Research Institute
2022-2025
Vancouver General Hospital
2025
Prevent Blindness
2010-2021
Horizon Therapeutics (United States)
2021
Research to Prevent Blindness
2011-2021
Massachusetts General Hospital
2018-2021
To present a modified evisceration technique with full-thickness horizontal sclerotomy and assess post-operative motility long-term outcomes. This is retrospective chart review of patients who underwent single surgeon (TJM). The standard initial steps were performed. Before implant placement, complete radial was extended posteriorly at the 3 9 o'clock positions, 2 mm above optic nerve, longitudinally dividing medial lateral rectus insertions. scleral halves mobilized, allowing them to...
Invasive fungal infections of the head and neck are rare life-threatening where prompt diagnosis intervention is critical for survival. The aim this study to determine clinical characteristics outcomes invasive disease sinus orbit, compare mucormycosis Aspergillus infection.A retrospective review was conducted from a single tertiary care eye ear hospital over 20 years (1994-2014). Twenty-four patients with confirmed pathological and/or orbit were identified their medical records reviewed....
purpose. This study was designed to assess the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome. methods. Five members were studied, using clinical examination, nerve conduction studies, perimetry, optical coherence tomography (OCT) measures central retinal thickness, electroretinography. High-resolution images adaptive optics scanning laser ophthalmoscopy (AOSLO) obtained...
Purpose: This study analyzed the degree and timing of proptosis regression after teprotumumab therapy. Methods: A retrospective all patients who completed 8 infusions at 1 institution from January 1, 2020 to December 31, 2022. Change in was assessed millimeters percentages compared with immediate post-treatment pretreatment proptosis. Results: Of 119 data (mean follow-up 10.56 months, range: 3.05–25.08), 208 (87.39%) eyes 110 had initial improvement. 78 multiple visits, 102 (65.38%) 59...
<b>Aim:</b> To determine the disease causing gene defects in two patients with Meesmann's corneal dystrophy. <b>Methods:</b> Mutational analysis of domains 1A and 2B keratin 3 (K3) 12 (K12) genes from dystrophy was performed by polymerase chain reaction amplification direct sequencing. <b>Results:</b> Novel mutations K12 were identified both patients. In one patient a heterozygous point mutation (429A→C = Arg135Ser) found domain gene. This confirmed restriction digestion. second 27 bp...
Purpose: To review the treatment response of advanced conjunctival squamous cell carcinoma (SCC) to systemic immune checkpoint inhibitor (ICI) therapy at a single institution. Methods: A retrospective patients treated institution from 2015 2024 was conducted identify those with SCC who had been ICI therapy. Advanced disease included orbital invasion tumors, unresectable disease, or metastatic disease. Computed tomography imaging and tumor mutational burden data were evaluated for all...
In this case series, the authors report three patients with severe atopic dermatitis who presented epiphora and conjunctivitis while undergoing dupilumab therapy. On clinical examination, all were found to have punctal stenosis, one having progressed obstruction. An assortment of strategies was elected, including discontinuation dupilumab, treatment conjunctivitis, surgical intervention probing, punctoplasty, silicone intubation. This spotlights stenosis as an important new side effect...
Successful repair of the orbital skeleton restores function and cosmesis by normalizing globe position allowing full motility extraocular muscles. Routine repairs are successful with standard implants. However, defects that irregular or cause volume deficiency can be challenging to repair. The development patient specific implants (PSI) offers an additional tool in complex cases. Herein, we report our experience using PSI for reconstruction.An IRB-approved review was conducted consecutive...
Purpose The current study queries the American Academy of Ophthalmology (AAO) Intelligent Research in Sight (IRIS) registry for data on epidemiology, work-up, and management patterns autoimmune orbital inflammation.
Ophthalmic immune-related adverse events (Eye-irAEs) from immune checkpoint inhibitors can cause visual morbidity. The absence of standardized definitions for Eye-irAEs not only impedes the development evidence-based treatments but also progress in translational research. objective this study was to develop consensus guidance an approach Eye-irAEs. Four ophthalmic physicians (uveitis specialists and neuro-ophthalmologists) drafted Eye-irAE definitions, which were reviewed by...
Computed tomography (CT) uses Hounsfield units (HU) for density, which is a standardized unit of measure. This study created HU reference guide and evaluates the use orbital lesions normal structures. Retrospective chart review at two academic centers identified patients with biopsy proven CT imaging. Patients structures were included as normative database. was measured. The 219 50 control total 341 images. Of these, 241 images lesions, 137 non-contrast 104 contrast. There contrast scans....