Müjdat Uysal

ORCID: 0000-0002-8802-8766
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About
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Research Areas
  • Biochemical effects in animals
  • Liver Disease Diagnosis and Treatment
  • Antioxidant Activity and Oxidative Stress
  • Aldose Reductase and Taurine
  • Alcohol Consumption and Health Effects
  • Free Radicals and Antioxidants
  • Diet, Metabolism, and Disease
  • Vitamin C and Antioxidants Research
  • Fatty Acid Research and Health
  • Drug-Induced Hepatotoxicity and Protection
  • Folate and B Vitamins Research
  • Eicosanoids and Hypertension Pharmacology
  • Adipose Tissue and Metabolism
  • Sulfur Compounds in Biology
  • Liver Disease and Transplantation
  • Heme Oxygenase-1 and Carbon Monoxide
  • Biochemical Acid Research Studies
  • Advanced Glycation End Products research
  • Thyroid Disorders and Treatments
  • DNA Repair Mechanisms
  • Genomics, phytochemicals, and oxidative stress
  • Birth, Development, and Health
  • Atherosclerosis and Cardiovascular Diseases
  • Healthcare and Venom Research
  • Diet and metabolism studies

Istanbul University
2013-2024

Bakırköy Psychiatric Hospital
2023

Yeditepe University
2017

Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2017

Plovdiv University
2014

University of Nis
2014

Konkuk University
2014

Ain Shams University
2014

Near East University
2007

Balikli Rum Vakfi Hastanesi
2000

Thioacetamide (TAA) administration (0.3 g/l of tap water for a period 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings. This treatment caused an increase the levels malondialdehyde (MDA) diene conjugates (DCs) decrease glutathione (GSH), vitamin E, C activities peroxidase (GSH-Px) liver rats. Superoxide dismutase (SOD) were unchanged. Taurine (2% w/w, added chow diet) was administered together with TAA drinking water) months. found...

10.1191/096032701678227758 article EN Human & Experimental Toxicology 2001-05-01

Lipid peroxidation and the antioxidant system were investigated in plasma placenta of normal preeclamptic pregnant women. A significant increase thiobarbituric acid reactive substance (TBARS), decreases total thiol (t-SH) content superoxide dismutase (SOD) activity, unchanged vitamin C levels glutathione peroxidase (GPx) activity observed women compared to with pregnancies. In placentas from TBARS significantly elevated, while GPx, S-transferase SOD activities decreased. After delivery,...

10.1159/000009994 article EN Gynecologic and Obstetric Investigation 1998-01-01

Doxorubicin (DOX) is known to increase in oxidative stress several organs. Olive leaf extract (OLE) has potent antioxidant effects; therefore, we evaluated the ability of OLE reduce DOX-induced toxicity heart, liver, and kidneys rats. DOX (30mg/kg; i.p.) was administered rats, which were sacrificed 4 days after DOX. The rats received (6 12mL/L drinking water) for 12 days. Serum cardiac troponin I (cTnI) levels, alanine aminotransferase (ALT), aspartate (AST) activities, urea creatinine as...

10.1016/j.pathophys.2015.04.002 article EN Pathophysiology 2015-05-07

The effect of a high-cholesterol diet with or without taurine on lipids and oxidative stress in the plasma, liver aorta rabbits was investigated. animals were maintained basal (control), (HC, 1% w/w), high- cholesterol supplemented (HCHT, 2.5% w/w) for two months. Taurine has an ameliorating atherosclerosis together decreasing triglyceride levels fed HC diet. HCHT caused significant decrease malondialdehyde (MDA) diene conjugate (DC) as compared to group. This treatment did not alter...

10.1271/bbb.66.1755 article EN Bioscience Biotechnology and Biochemistry 2002-01-01

Summary Ulcerative colitis (UC) is a multi-factorial inflammatory disease of the colon and rectum. The present study was undertaken to investigate effect taurine, an anti-oxidant amino acid, on oxidative stress expression apoptosis-related proteins, pro-apoptotic Bax anti-apoptotic B cell lymphoma-2 (Bcl-2) in tissue rats with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Rats received taurine (1·5% w/v) drinking water for 15 days before after administration TNBS solution....

10.1111/j.1365-2249.2008.03599.x article EN Clinical & Experimental Immunology 2008-01-30

Aim Olive leaf (Olea europaea L.) extract (OLE) is a powerful anti-oxidant rich in polyphenols. As oxidative stress plays an important role aging, we investigated the effect of OLE on liver, heart and brain aged rats. Methods Young (age 3 months) 20 Wistar rats were used. Aged received (500 1000 mg/kg/day) drinking water for 2 months. Malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC), glutathione (GSH), vitamin E C levels, superoxide dismutase (SOD), peroxidase (GSH-Px)...

10.1111/ggi.12192 article EN Geriatrics and gerontology international/Geriatrics & gerontology international 2014-05-23

Summary High‐fat diet ( HFD ) and low‐dose streptozotocin STZ )‐treated rats provide useful animal model for type II diabetes mellitus. Oxidative stress advanced glycation end products AGE s) play a role in the development of diabetic complications. Carnosine CAR has anti‐oxidant anti‐glycating properties. We investigated effects on oxidation + rats. Rats were fed with (60% total calories from fat) 4 weeks, then single dose (40 mg/kg; i.p.) was applied. blood glucose levels above 200 mg/ dl...

10.1111/iep.12252 article EN International Journal of Experimental Pathology 2017-10-01

In this study, we evaluated whether taurine treatment has a protective effect on the prooxidant-antioxidant state following chronic ethanol in rats. Rats were given water containing 20% (v/v) as drinking for 3 months. Chronic resulted increased oxidative stress liver of Taurine was performed by adding 1% (w/v) to plus injection (400 mg/kg body weight) intraperitoneally times/week 28 d after cessation chronically ethanol-treatad This starting caused significant decreases serum transaminase...

10.1248/bpb.25.1231 article EN Biological and Pharmaceutical Bulletin 2002-01-01
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