A5078021127- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Heat shock proteins research
- Evolution and Genetic Dynamics
- Adipose Tissue and Metabolism
- Microbial infections and disease research
- CRISPR and Genetic Engineering
- Listeria monocytogenes in Food Safety
- Aquaculture disease management and microbiota
- Muscle metabolism and nutrition
- Viral Infections and Vectors
- Microbial Community Ecology and Physiology
- Plant Virus Research Studies
- Mitochondrial Function and Pathology
- Genetically Modified Organisms Research
- Methane Hydrates and Related Phenomena
University of Arkansas at Fayetteville
2015-2025
Crouse Hospital
2015
Wildlife have become increasingly dependent on anthropogenic resources, altering interactions between individuals and subsequently disease transmission. Further, nutritional quantity quality impact an individual's ability to mitigate damage caused by infectious disease. Thus, understanding how diet affects immune function is critical for predicting severity Here, we use transcriptomics explore the previously unstudied molecular mechanisms underpinning diet-driven differences in pathogen...
Abstract As humans alter the landscape, wildlife have become increasingly dependent on anthropogenic resources, altering interactions between individuals and subsequently disease transmission dynamics. Further, nutritional quantity quality greatly impact an individual host’s immune capacity ability to mitigate damage caused by infectious disease. Thus, understanding of dietary nutrition function is critical for predicting severity as human activity both facilitates dispersal pathogens alters...
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A challenge in virology is quantifying relative virulence (
Archaeal group II chaperonins, also known as heat shock proteins (HSPs), are abundantly expressed in Sulfolobales. HSPα and HSPβ gene expression is upregulated during thermal shock. HSPs form large 18-mer complexes that assist folding nascent protecting resident stress. Engineered have been designed for industrial applications. Since temperature flux the geothermal habitats of Sulfolobales impacts intracellular temperature, it follows developed thermotolerance. However, despite low pH (i.e.,...
ABSTRACT The Sulfolobus Spindle-shaped Virus (SSV) system has become a model for studying thermophilic virus biology, including archaeal host-virus interactions and biogeography. Several factors make the SSV amenable to genetic mechanisms (e.g., CRISPRs) as well virus-host in high temperature acidic environments. First, it been shown that endemic populations of , reported host, exhibit biogeographic structure. Second, (pH<4.5) (65-88°C) habitats have low biodiversity, thus, diminishing...
Abstract Crenarchaeal group II chaperonins (a.k.a., “heat shock” proteins, HSPs) are abundantly expressed in species of the family Sulfolobaceae . HSPα and HSPβ expression is upregulated during thermal shock. HSPs subunits larger octadecameric complexes that function to protect intracellular proteins stress. Engineered have been constructed with idea protecting enzymes industrial reactions. HSPβ-coh, a fusion protein comprised type 1 cohesin from Clostridium thermocellum was used for...
Mitochondrial dysfunction is a key in the development of metabolic diseases. The mitochondrial genome contains 37 genes, 13 protein encoding which are all vital to electron transport system (ETS) and therefore function. mitochondria have specialized equipment regulating mRNA translation these genes. Little previous work has been published examine regulation machinery disease or physical activity. PURPOSE: To determine influence diet-induced obesity activity on how this regulated. METHODS: 40...
A bstract One of the more challenging aspects in quantitative virology is quantifying relative virulence between two (or more) viruses that have different replication dynamics a given susceptible host. Host growth curve analysis often used to detail virus-host interactions and determine impact viral infection on Quantifying using canonical parameters such as maximum specific rate (μ max ) can fail provide accurate information regarding experimental infection, especially for non-lytic...
The Sulfolobus Spindle-shaped Virus (SSV) system is a model for studying thermophilic archaeal virus biology. Several factors make the SSV amenable to genetics and virus-host interactions in extreme environments. It has been shown that populations of Sulfolobus, natural host, exhibit biogeographic structure. acidic (pH<4.5) high temperature (65-88°C) habitats have low biodiversity, which diminishes prospects host switch. SSVs their hosts are readily cultured liquid media on plates. Given...