Optical properties of the rat head tissues (brain cortex, cranial bone and scalp skin) are assessed, aiming at transcranial light applications such as optical imaging phototherapy. The spectral measurements carried out over wide range 350 to 2800 nm, involving visible, near‐infrared (NIR) short‐wave infrared (SWIR) regions. Four tissue transparency windows considered: ~700 1000 nm (NIR‐I), ~1000 1350 (NIR‐II), ~1550 1870 (NIR‐III or SWIR) ~2100 2300 (SWIR‐II). values attenuation coefficient...

Low-intensity light can decelerate neurodegenerative disease progression and reduce amyloid β (Aβ) levels in the cortex, though cellular molecular mechanisms by which photobiomodulation (PBM) protects against neurodegeneration are still early stages. Microglia cells play a key role pathology of Alzheimer's causing chronic inflammation. We present new results concerning PBM both oxidative stress microglia metabolism associated with activation metabolic processes 808 nm near-infrared light.The...

Red and near-infrared (NIR) light effect on Ca2+ ions flux through the influence N-methyl-D-aspartate receptors (NMDARs) their functioning in HeLa cells was studied vitro. Cells were irradiated by 650 808 nm laser at different power densities doses obtained compared with that caused pharmacological agents. The found to elevate influx into cell cytoplasm a dose-dependent manner without changes of NMDAR functioning. Furthermore, both wavelengths demonstrated ability under blockade NMDARs also...

Low-level light therapy (LLLT) is emerging as a promising therapeutic approach to modulate the biochemical and molecular processes within living cells. LLLT known produce local systemic effects; therefore, immune cells in tissues or circulation are affected by light. However, this specific effect remains weakly explored. In study, of red (650 nm) NIR (808 on phagocytosis (respiratory burst), cytokine expression, mitochondrial activity, ROS generation, Ca2+ influx membrane depolarization...

We have analysed the influence of complex drug cocarnit (20 mg nicotinamide, 50 cocarboxylase, 0.5 cyanocobalamin, 10 disodium adenosine triphosphate trihydrate) on nerve conduction velocity in nervus tibialis rats with diabetic polyneuropathy.Our data shows that polyneuropathy leads to dysfunction signal effector.Administration showed linear dose-dependent therapeutic effect pathology.After 9 d course administration Cocarnit led almost complete time parameters renewal stimulation impulses...

The enteric nervous system (ENS) and a glutamate receptor (GluR), N-methyl-D-aspartate (NMDAR), participate in gastric acid secretion (GAS) regulation. NMDARs are localized different stomach cells; however, knowledge of NMDAR expression function the ENS is limited. In present study, we clarified types cells that express involved GAS pharmacological method isolated perfusion by Ghosh Shild combined with direct mapping fluorescence microscopy rat was employed. By immunofluorescence labeling an...

Abstract Mesenchymal stem cells (MSCs) being injected into the body can stimulate or decelerate carcinogenesis. Here, direction of influence human placenta‐derived MSCs (P‐MSCs) on Lewis lung carcinoma (LLC) tumor development and metastatic potential is investigated in C57BL/6 mice depending injection method. After intramuscular co‐inoculation LLC P‐MSCs (LLC + P‐MSCs), growth primary angiogenesis are slowed down compared to control 15th day. This explained by fact a decrease secretion...

Background:Recombinant hemagglutinin (rHA) and neurominidase (rNA) developed in our investigation are amino acid sequence consensus variants of H1N1 2009 subtype influenza virus strain, also including immunogenic epitopes typical for other subtypes (H3N1 H5N1).Substitutions were made: Russian isolates (in HA -S220T, NA -D248N) active centers molecules -R118L, R293L, R368L; C92S, C417S to increase recombinant proteins stability E. coli.The aim the present work was study immunogenicity...

The quality and biological effects of the waste waters released by Baikalsk Pulp Paper Mill were monitored chemically biologically. In 1:5 dilution, treated water induced monooxygenase activity in liver grayling bullhead standardised laboratory conditions. Ames test was used to monitor mutagenicity mill tissue extracts fish, sponge, mollusc plankton collected near seals from middle part lake. Mutagens found produced during pulp chlorination before treatment a few samples fully 10 years...

Wound healing which is a usual biological process in our body attained by four accurate and highly organized stages: hemostasis, inflammation, proliferation, remodeling. In order to achieve proper successful wound healing, all these stages must occur an appropriate sequence under certain period of time. Many factors can disturb one or more stage this process, hence resulting inappropriate ruined healing.Aim research. This article investigates the influence nanoceria on C-reactive protein...

We have shown NMDAR expression in cell transformation process at early stages of cancer, specifically HCC. The aim our study was to define the disease from precancerous liver towards cancer progression when subunits were expressed/detected. A fibrosis/HCC rat model, immunohistochemistry combined with epifluorescence microscopy imaging, Western blotting used. dynamics appearance subunits, their and methylation status during development HCC discussed.

the activity of enzymes respiratory chain and structural-dynamic properties inner mitochondrial membrane (IMM) sarcoma 37 (S37) in mice under sodium dichloroacetate (SDa) administration a daily dose 86 mg/kg body weight starting from 2 nd day after tumor transplantation were investigated.The dynamic structural state IMM components was determined using fluorescent probes.With S37 growth intensification glycolytic metabolism occurred on background suppressed functional capacity enzymes.the...

We investigated the energy activity of mitochondria from rat cardiomyocytes under artificial carbon dioxide hypobiosis, which led to physiological changes in organism (the decrease body temperature, reduction heart rate, etc.). The respiratory and phosphorylation activities is reduced when using two oxidation substrates (succinate malate), characterize rate oxygen consumption by mitochondria. partial uncoupling processes malate unlike succinate was established. NADH-KoQ-oxidoreductase...

Abstract The quality and biological effects of the waste waters released by Baikalsk Pulp Paper Mill were monitored chemically biologically. In 1:5 dilution, treated water induced monooxygenase activity in liver grayling bullhead standardised laboratory conditions. Ames test was used to monitor mutagenicity mill tissue extracts fish, sponge, mollusc plankton collected near seals from middle part lake. Mutagens found produced during pulp chlorination before treatment a few samples fully 10...

The change of pain threshold in rats with diabetic polyneuropathy and the efficacy Cocarnit treatment this complication has been studied, optimal scheme drug administration determined. It is established that daily for 9 12 days a positive effect on nerve conduction returns to normal response stimulus.

The mutagenicity of bleached pulp mill effluents was compared to the unbleached waste waters. Mutagenicity assessed with Ames test, using metabolic activation systems isolated from liver rats and fish. Liver extracts fish caught in polluted areas, experimentally exposed water, were also investigated. Pulp taken after chlorination showed mutagenic activity. activity diminished during water treatment. Tissue various concentrations treated only slight a few samples. In case monooxygenase...

We described clinical cases of scleral lenses fitting in patients with induced ametropia and have shown the efficiency this optical correction. High functional results comfortable use make main correction method for irregular corneas after refractive surgery procedures.

Abstract The mutagenicity of bleached pulp mill effluents was compared to the unbleached waste waters. Mutagenicity assessed with Ames test, using metabolic activation systems isolated from liver rats and fish. Liver extracts fish caught in polluted areas, experimentally exposed water, were also investigated. Pulp taken after chlorination showed mutagenic activity. activity diminished during water treatment. Tissue various concentrations treated only slight a few samples. In case...

The optical permeability of rat head tissues, such as brain cortex, cranial bone and skin has been determined in the visible, near-infrared short-wave infrared regions, aiming towards trough-skull imaging.

Minor injuries in healthy people usually heal well, but larger wounds or the presence of various physiological (age) pathological conditions (metabolic syndrome, obesity, diabetes, and cancer) can impede this process. The aim our work was to determine factors that may influence duration healing (growth hypoxia-induced factor 1α) wound bed rats with metabolic syndrome. experiments were conducted on 80 white non-linear laboratory rats, aged 4-5 months, which divided after birth into 2 groups...