A5045239680- Diet and metabolism studies
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Skin Protection and Aging
- Wound Healing and Treatments
- Pancreatitis Pathology and Treatment
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Neurological Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Nutrition, Genetics, and Disease
- Mycorrhizal Fungi and Plant Interactions
- Advanced Nanomaterials in Catalysis
- Dermatologic Treatments and Research
- Regulation of Appetite and Obesity
- Nanoparticles: synthesis and applications
- Digestive system and related health
- Probiotics and Fermented Foods
- bioluminescence and chemiluminescence research
- Salivary Gland Disorders and Functions
Taras Shevchenko National University of Kyiv
2015-2024
Danylo Zabolotny Institute of Microbiology and Virology
2024
Ukrainian Medical Stomatological Academy
2014-2019
Bogomolets National Medical University
2011-2017
University of Southern California
2000
OBJECTIVE To evaluate the therapeutic effect of a probiotic cocktail containing Lactobacilli , Bifidobacteria and Streptococcus thermophilus on non‐alcoholic steatohepatitis (NASH). METHODS In this open‐label trial, 75 patients with NASH fed low‐fat/low‐calorie diet were randomly divided into control group experimental group, latter receiving once daily for 12 weeks. RESULTS All diagnosed fatty liver by ultrasound examination had elevated levels γ‐glutamyl transferase (GGT) alanine...
Male infertility has largely idiopathic, multifactorial origin. Oxidative stress is a major factor that affects spermatogenesis, in particular aging. Cerium dioxide nanoparticles (CNPs) due to their antioxidative properties are promising impact on the development of male infertility. The aims this study were investigate effects CNPs fertility parameters 24-month rats and overview relevant literature field personalized treatments, predictive diagnosis, preventive measures for health...
Abstract Introduction Obesity becomes endemic today. Monosodium glutamate was proved as obesogenic food additive. Probiotics are discussed to impact on obesity development. Aims and objectives The aim study the effects of probiotics development monosodium (MSG)-induced in rats. Material methods We included 45 Wistar male rats divided into three groups ( n = 15). Newborn group 1 (control) received subcutaneously 8 μl/g saline. Group 2 3 4 mg/g MSG second, fourth, sixth, eighth tenth day life....
Today the impairment of metabolism and obesity are being extensively investigated due to significant increase prevalence these diseases. There is scientific evidence that probiotics beneficial for human health. Thus, aim study was investigate effect multiprobiotic "Symbiter acidophilic concentrated" on parameters in rats under experimental obesity. The carried out 60 newborn Wistar rats, divided into 3 groups, 20 animals each (females – n = 10, males 10): intact monosodium glutamate (MSG-)...
Introduction and aim. Today probiotics have been suggested as a treatment for the prevention of non-alcoholic fatty liver disease (NAFLD). Smectite is natural silicate that binds to digestive mucous has ability bind endo- exotoxins. The present study was designed determine whether plus smectite superior probiotic alone on monosodium glutamate (MSG) induced NAFLD model in rats. Materials methods. We included 60 rats divided into 4 groups 15 animals each. Rats group I were intact. Newborns...
Introduction: a comparative animal study of the efficacy intermittent short-course administration lyophilised single-, three-, and live multistrain probiotic on obesity. Methods: We included 70 rats divided into seven groups (n = 10 in each). Rats group I were intact. Newborn II–VII injected with monosodium glutamate (MSG) (4 mg/g). II (MSG-obesity group) untreated. The III-V received monoprobiotics B. animalis VKL , VKB L. casei IMVB-7280 respectively. Group VI mix these three strains. VII...
To investigate the efficacy of different probiotic strains, their combinations and forms (alive or lyophilized) in nonalcoholic fatty liver disease (NAFLD) prevention. In this study, 70 rats have been used divided into 7 groups 10 animals each: I – intact rats, II-VII with monosodium glutamate (MSG)-induced NAFLD. Rats NAFLD were untreated (group II, MSG-obesity group) treated probiotics (groups III–VII). order to develop NAFLD, newborn II–VII injected a solution (MSG) (4 mg/g)...
Background. One of the pathogenic mechanisms nonalcoholic fatty liver disease (NAFLD) is accumulation reactive oxygen species, which in turn aggravates progress. We have investigated novel cerium dioxide nanoparticles (nCeO2) due to their promising antioxidant auto-regenerative ability and low toxicity.Methods. 30 white male Wistar rats were divided into 3 groups: control, monosodium glutamate (MSG)-induced obesity MSG treated with nCeO2 (MSG+nCeO2) groups. Newborn control group injected...
Nowadays, we face the global epidemic of obesity, that is known to contribute development many diseases, such as oral cavity pathologies. Dental and pathologies are frequently caused by overlapped with systemic multifactorial diseases obesity being its early indicators risk factors. The aim was study influence nanoceria on periodontal tissues alteration in glutamate (MSG)-induced obese rats.We included 52 Wistar rats both genders divided into four groups: newborn group 1 (control) received...
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels lipid peroxidation products activities antioxidative system enzymes measured mucosa correlated observed gastroprotective...
The influence of prolonged administration monosodium glutamate (MSG) on pancreas in rats was studied. It established that 30-days feeding by MSG the doses 15 to 30 mg/kg (equivalent 1 and 2 g/person) leads necrotic, necrobiotic degenerative changes exocrine endocrine cells, leukocytic lymphoid infiltration, perivascular interstitial fibrosis, edema discirculatory disorders. Introduction sodium increases cross-sectional area nuclei ofexocrine indicating intensification synthetic processes...
The aim of this study was to investigate the effect probiotic strains Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. VKB on pro-and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity.It established that neonatal administration MSG leads increasing levels interleukin (IL)-1β and IL-12, decreasing IL-4, IL-10 tumor growth factor (TGF)-β blood serum.After VKL -B.animalis -L.casei B-7280 composition obese level IL-1β serum...
The pathogenesis of hepatic encephalopathy (HE) is only partially understood. Beside ammonia accumulation in brain, a proinflammatory component has been suggested as precipitating event.To evaluate the role cytokines cirrhosis for development HE.Pro- and anti-inflammatory cytokine profiles were determined rats with CCL4-induced HE well patients either due to metabolic disorders or chronic hepatitis C virus (HCV) various grades concomitant depression.In rat model human pattern (elevation...
We have analysed the influence of complex drug cocarnit (20 mg nicotinamide, 50 cocarboxylase, 0.5 cyanocobalamin, 10 disodium adenosine triphosphate trihydrate) on nerve conduction velocity in nervus tibialis rats with diabetic polyneuropathy.Our data shows that polyneuropathy leads to dysfunction signal effector.Administration showed linear dose-dependent therapeutic effect pathology.After 9 d course administration Cocarnit led almost complete time parameters renewal stimulation impulses...
Abstract Background Constipation is a common condition, with prevalence after 65 years, major colorectal cancer risk factor. Recent works have demonstrated advances in personalized, preventive nanomedicine, leading to the construction of new materials and nanodrugs, particular, nanocrystalline cerium dioxide (NCD), having strong antioxidative prebiotic effect. The aim our study was investigate influence NCD on motor function stomach colon vivo contractive activity smooth muscles different...
Background: According to modern concepts of burn disease development, one the main complications is inflammation occurrence. Despite large number drugs used treat effects chemical burns esophagus, we find conflicting information in literature about their effectiveness. Moreover problem wound healing process quickening, as well prevention measures against possible post are really relevant if aim subjective portability rehabilitation period facilitation.
 Methods: Study immune system...
The enteric nervous system (ENS) and a glutamate receptor (GluR), N-methyl-D-aspartate (NMDAR), participate in gastric acid secretion (GAS) regulation. NMDARs are localized different stomach cells; however, knowledge of NMDAR expression function the ENS is limited. In present study, we clarified types cells that express involved GAS pharmacological method isolated perfusion by Ghosh Shild combined with direct mapping fluorescence microscopy rat was employed. By immunofluorescence labeling an...
The effective biocompatible and partially biodegradable micellar nanocarriers for encapsulation of the anticancer drug eumelanin were created. Such nanocarries are products self-assembly asymmetric diblock triblock copolymers, which comprised chemically complementary (methoxy)poly(ethylene oxide) poly(acrylic acid) blocks a variable length. A chemical structure solubility eumelanin, vital activity product black yeast "Nadsoniella nigra sp. X-1, was characterized. Peculiarities micellization...