A5017489689- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Paranormal Experiences and Beliefs
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Cognitive Science and Education Research
- Death Anxiety and Social Exclusion
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Psychedelics and Drug Studies
- Heart Rate Variability and Autonomic Control
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Spatial Neglect and Hemispheric Dysfunction
- Sleep and Wakefulness Research
- Dupuytren's Contracture and Treatments
- Prion Diseases and Protein Misfolding
- Medical Imaging and Analysis
- Inflammatory Myopathies and Dermatomyositis
University of Virginia
2024-2025
University of California, Los Angeles
2022-2024
University of Virginia Health System
2024
National Institutes of Health
2020-2023
National Institute on Aging
2017-2023
Universidade Estadual de Campinas (UNICAMP)
2013-2022
Universidade Federal de Juiz de Fora
2022
Institute on Aging
2019-2021
Hospital de Clínicas da Unicamp
2013-2017
Universidade de São Paulo
2017
The projected burden of dementia by Alzheimer's disease (AD) represents a looming healthcare crisis as the population most countries grows older. Although there is currently no cure, it possible to treat symptoms dementia. Early diagnosis paramount development and success interventions, neuroimaging one promising areas for early detection AD. We aimed deploy advanced deep learning methods determine whether they can extract useful AD biomarkers from structural magnetic resonance imaging...
Alzheimer´s disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions functional connectivity networks (FCNs), especially memory related default mode network (DMN). However, little known about integrity clinical significance FNCs that process other than memory. We evaluated 22 patients mild 26 healthy controls through a resting state...
There is evidence that the default mode network (DMN) functional connectivity impaired in Alzheimer's disease (AD) and few studies also reported a decrease DMN intrinsic activity, measured by amplitude of low-frequency fluctuations (ALFFs). In this study, we analyzed relationship between activity connectivity, as well their possible implications on cognition patients with mild AD amnestic cognitive impairment (aMCI) healthy controls. addition, evaluated differences both ALFF values these...
Background: Longitudinal MRI studies in Alzheimer's disease (AD) are one of the most reliable way to track brain changes along course disease. Objective: To investigate evolution grey matter (GM) atrophy and white (WM) damage AD patients, assess relationship s with baseline clinical cognitive variables their over time. Methods: Clinical, neuropsychological, assessments (T1-weighted diffusion tensor [DT]-MRI) were obtained from 14 patients at after a 16 ± 3 month period. Lumbar puncture was...
Despite extensive discussions, a consensus is lacking on whether out-of-body experiences (OBEs) and lucid dreams (LDs) should be considered as distinct categories of experience, if so, what differentiates them. To address this issue, we first discussed the implications OBEs LDs same type phenomena. We then compiled comprehensive list experiential features associated with LDs, aiming to identify distinguishing criterion between conclude that neither previously proposed nor interpretation...
Alzheimer's disease (AD) is the most common form of dementia, with no means cure or prevention. The presence abnormal disease-related proteins in population is, turn, much more than incidence dementia. In this context, CR hypothesis has been proposed to explain discontinuity between pathophysiological and clinical expression AD, suggesting that mitigates effects pathology on cognition. fMRI studies human connectome have recently reported AD patients present diminished functional efficiency...
Abstract Introduction Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent training on cognition and brain structure in aMCI subjects cerebral spinal fluid positive AD biomarkers. Methods Forty were divided (multicomponent thrice a week for 6 months) nontraining groups. Assessments included cardiorespiratory fitness, neurocognitive tests,...
Cognitive impairment is a common consequence of stroke, and the rewiring surviving brain circuits might contribute to cognitive recovery. Studies investigating how functional connectivity networks change across time whether their remapping relates recovery in stroke patients are scarce. We aimed investigate resting-state was associated with performance if any alterations these were correlated recovery.Using an fMRI ROI-ROI approach, we compared ipsilesional, contralesional interhemispheric...
Background: It is widely known that atrophy of medial temporal structures present in the mild stage Alzheimer's disease (AD) and amnestic cognitive impairment (aMCI). However, such as thalamus corpus callosum are much less studied. Methods: We compared volumes entorhinal cortex, hippocampus, 14 controls, patients with AD 15 aMCI correlated these neuropsychological data. MRI was obtained at 2 T followed by manual segmentation. Results: found hippocampi thalami MCI to bilateral cortex...
An out-of-body experience (OBE) is a phenomenon in which an individual experiences detachment of their consciousness from physical body. The neural mechanisms underlying OBEs remain elusive, primarily due to unpredictable and spontaneous nature, making study particularly challenging. Using individuals who can self-induce laboratory setting could be fruitful avenue for advancing our understanding the signatures accompaniments these experiences. However, significant challenge associated with...
<h3>Background:</h3> In the last decade, many studies have reported abnormal connectivity within default mode network (DMN) in patients with Alzheimer disease. Few studies, however, investigated other networks and their association pathophysiological proteins obtained from cerebrospinal fluid (CSF). <h3>Methods:</h3> We performed 3 T imaging mild disease, amnestic cognitive impairment (aMCI) healthy controls, we collected CSF samples aMCI analyzed 57 regions 8 networks. Additionally,...
Abstract Resting‐state functional MRI is increasingly used in the clinical setting and now included some diagnostic guidelines for severe brain injury patients. However, to ensure high‐quality data, one should mitigate fMRI‐related noise typical of this population. Therefore, we aimed evaluate ability different preprocessing strategies noise‐related signal (i.e., in‐scanner movement physiological noise) connectivity (FC) traumatic (TBI) We applied nine commonly denoising strategies, combined...
Repetitive Transcranial Magnetic Stimulation (rTMS) has shown initial promise in combating age-related cognitive decline and dementia. The nature severity of aging, however, varies markedly between individuals.We hypothesized that the distinct constellation brain changes responsible for individual differences aging might influence response to rTMS.Cognitive effects rTMS were evaluated using a rat model which aged rats are classified as Aged-Impaired (AI) or -Unimpaired (AU) relative young...
The mind-body problem remains a central issue in the philosophy of mind. This paper examines how out-of-body experiences (OBEs) might provide insights into relationship between mind and body. Four interpretations OBEs are considered. first posits that arise from neural or sensory dysfunction, framing them as products brain activity. From this perspective, akin to other subjective experiences, with viewed two aspects same underlying reality. Secondly, anecdotal evidence some experimental may...