A5063540800- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Olfactory and Sensory Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Zebrafish Biomedical Research Applications
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Child and Animal Learning Development
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Cognitive Functions and Memory
- Retinal Development and Disorders
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
Center for Research and Advanced Studies of the National Polytechnic Institute
2024
Institute on Aging
2021-2022
National Institute on Aging
2020-2022
National Institutes of Health
2020-2022
Universidad Nacional Autónoma de México
2010-2020
Previous findings indicate that the acquisition and consolidation of recognition memory involves dopaminergic activity. Although dopamine deregulation has been observed in Alzheimer's disease (AD) patients, dysfunction this neurotransmitter not investigated animal models AD. The aim study was to assess, by vivo microdialysis, cortical hippocampal dopamine, norepinephrine, glutamate release during object (ORM) 5- 10-mo-old triple-transgenic mice (3xTg-AD) relate extracellular changes 24-h...
Detecting novelty is critical to consolidate declarative memories, such as spatial contextual recognition memory. It has been shown that stored when retrieved, are susceptible modification, incorporating new information through an updating process. Catecholamine release in the hippocampal CA1 region consolidates object location memory (OLM). This work hypothesized could be changed by decreasing catecholamine terminals from locus coeruleus (LC). In a mouse model expressing Cre-recombinase...
The detection and processing of novel information encountered in our environment is crucial for proper adaptive behavior learning. Hippocampus a prime structure novelty that receives high-level inputs including context information. It interest to understand the mechanisms by which hippocampus processes contextual For this, we performed vivo microdyalisis order monitor extracellular changes neurotransmitter levels during Object Location Memory (OLM), behavioral protocol developed evaluate...
It has been postulated that memory consolidation process requires post-learning molecular changes will support long-term experiences. In the present study, we assessed with in vivo microdialysis and capillary electrophoresis whether such involve release of neurotransmitters at post-acquisition stages. Using conditioned taste aversion paradigm observed spontaneous off-line (i.e. absence stimulation) dopamine glutamate reactivation within insular cortex about 45 min after stimuli association....
It has been proposed that distributed neuronal networks in the medial temporal lobe process different characteristics of a recognition event; hippocampus associated with contextual recollection while perirhinal cortex linked familiarity. Here we show D1 dopamine receptor activity these two structures participates differentially object memory consolidation. The antagonist SCH23390 was infused bilaterally 15 min before 5 sample phase either rats' or dorsal hippocampus, and they were tested 90...
Abstract Findings have shown that anterior insular cortex (aIC) lesions disrupt the maintenance of drug addiction, while imaging studies suggest connections between amygdala and aIC participate in drug-seeking. However, role BLA → pathway rewarding contextual memory has not been assessed. Using a cre-recombinase under tyrosine hydroxylase (TH+) promoter mouse model to induce real-time conditioned place preference (rtCPP), we show photoactivation TH+ neurons induced electrophysiological...
Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation this structure is necessary for long-term storage conditioned taste aversion (CTA). However, specific neurotransmitters involved in such are not known. The aim present study was to investigate extracellular changes glutamate, norepinephrine, dopamine within rat amygdala using vivo microdialysis during 1-h CTA paradigm. Microdialysis monitoring...
Spontaneous recovery after a stroke accounts for significant part of the neurological in patients. However limited, spontaneous is mechanistically driven by axonal restorative processes which several molecular cues have been previously described. We report acceleration preclinical model ischemia/reperfusion rats via single intracerebroventricular administration extracellular vesicles released from primary cortical astrocytes. used magnetic resonance imaging and confocal multiphoton...
Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline. Reduced mitochondrial function may be an early event that compromises synaptic integrity neurotransmission in vulnerable brain regions during physiological pathological aging. Thus, we aimed to measure synapses from three at two different ages the 3xTg-AD mouse model wild mice. We found is main factor decline function, particularly isolated cerebellum. Accumulation of toxic compounds, such as tau Aβ,...
Repetitive Transcranial Magnetic Stimulation (rTMS) has shown initial promise in combating age-related cognitive decline and dementia. The nature severity of aging, however, varies markedly between individuals.We hypothesized that the distinct constellation brain changes responsible for individual differences aging might influence response to rTMS.Cognitive effects rTMS were evaluated using a rat model which aged rats are classified as Aged-Impaired (AI) or -Unimpaired (AU) relative young...
Abstract Rationale The accumulation of beta-amyloid peptide (Aβ) in the forebrain leads to cognitive dysfunction and neurodegeneration Alzheimer's disease. Studies have shown that individuals with a consistently cognitively active lifestyle are less vulnerable Aβ toxicity. Recent research has demonstrated intrahippocampal can impact catecholaminergic release spatial memory. Interestingly, exposure novelty stimuli been found stimulate catecholamines hippocampus. However, it remains uncertain...
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, precise molecular mechanisms linking Aβ deposition neurological are still unclear. Here we combine genome-wide transcriptional profiling insular cortex 3xTg-AD mice control littermates from early through late adulthood (2–14 months age), with behavioral biochemical in same animals identify determinants functional specifically...
Abstract Spontaneous recovery after a stroke accounts for major part of the neurological in patients. However limited, spontaneous is mechanistically driven by axonal restorative processes which several molecular cues have been previously described. We report acceleration preclinical model ischemia/reperfusion rats via single intracerebroventricular administration extracellular vesicles released from primary cortical astrocytes. used MRI, confocal and multiphoton microscopy to correlate...
Abstract We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created . The orbitofrontal cortex (OFC) typically thought access support model-based decision-making, it has recently been proposed that its critical contribution may be instead integrate information into existing and new models. tested between alternatives using an outcome-specific devaluation task a high-potency chemogenetic approach. found selectively...