A5001237504- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- HIV Research and Treatment
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
- HIV/AIDS Research and Interventions
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Ion Channels and Receptors
- Acute Ischemic Stroke Management
- HIV-related health complications and treatments
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Lipid Membrane Structure and Behavior
- biodegradable polymer synthesis and properties
- Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Phytochemicals and Antioxidant Activities
- Pregnancy-related medical research
Universidad Nacional Autónoma de México
2013-2024
Weatherford College
2007-2023
Instituto Nacional de Cardiología
2023
National Institute on Aging
2020
National Institutes of Health
2020
Johns Hopkins Medicine
2011-2017
Johns Hopkins University
2011-2017
Vesicles shed from astrocytes after brain trauma trigger hepatic cytokine release to mobilize the peripheral immune response.
Despite combination antiretroviral therapies (cARTs), a significant proportion of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND). Ongoing viral replication in the central nervous system (CNS) caused by poor brain penetration cART may contribute to HAND. However, it has also been proposed that toxic effects long-term A better understanding neurotoxic potential is critically needed light use CNS-penetrating cARTs contend with virus reservoir brain. The efavirenz...
Neuroinflammation is a unifying factor among all acute central nervous system (CNS) injuries and chronic neurodegenerative disorders. Here, we used immortalized microglial (IMG) cells primary microglia (PMg) to understand the roles of GTPase Ras homolog gene family member A (RhoA) its downstream targets Rho-associated coiled-coil-containing protein kinases 1 2 (ROCK1 ROCK2) in neuroinflammation. We pan-kinase inhibitor (Y27632) ROCK1- ROCK2-specific (RKI1447) mitigate lipopolysaccharide...
The Transient Receptor Potential Vanilloid 4 (TRPV4) channel has been shown to function in many physiological and pathophysiological processes. Despite abundant information on its importance physiology, very few endogenous agonists for this have described, underlying mechanisms activation clarified. TRPV4 is expressed by several types of cells, such as vascular endothelial, skin lung epithelial where it plays pivotal roles their function. In the present study, we show that activated...
Vascular endothelial growth factor (VEGF) delays disease onset and progression in transgenic rodent models of familial amyotrophic lateral sclerosis (ALS). Because most cases ALS are sporadic, it is important to determine whether VEGF can protect motoneurons a nontransgenic paradigm. We tested this possibility new model chronic excitotoxic spinal neurodegeneration the rat. Using osmotic minipumps, we continuously infused glutamate receptor agonist α-amino-3-hydroxy-5-methyl-4-isoxazole...
Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid anti-inflammatory effects; however, its efficacy remains controversial. Although MP thought to help resolution edema, there are no scientific grounds support this assertion. Aquaporin 4 (AQP4), most abundant component water channels CNS, participates...
Traumatic brain injury (TBI) is becoming an increasing public health issue. With annually estimated 1.7 million TBIs in the United States (U.S) and nearly 70 worldwide, injury, isolated or compounded with others, a major cause of short- long-term disability mortality. This, along no specific treatment, has made exploration TBI therapies priority system. Age sex differences create spectrum vulnerability to TBI, highest prevalence among younger older populations. Increased interest effects...
Traumatic brain injury (TBI) is a commonly occurring in sports, victims of motor vehicle accidents, and falls. TBI has become pressing public health concern with no specific therapeutic treatment. Mild (mTBI), which accounts for approximately 90% all cases, may frequently lead to long-lasting cognitive, behavioral, emotional impairments. The incretins glucagon-like peptide-1 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP) are gastrointestinal hormones that induce insulin...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause, characterized by the selective and progressive death both upper lower motoneurons, leading to paralysis. Experimental animal models may provide knowledge pathophysiological mechanisms allow design testing therapeutic strategies, provided that they mimic as close possible symptoms temporal progression human disease. The principal hypotheses proposed explain motoneuron degeneration have been studied...
J. Neurochem. (2010) 115 , 1090–1101. Abstract Vascular endothelial growth factor (VEGF) protects spinal motor neurons in models of familial amyotrophic lateral sclerosis. We previously demonstrated that VEGF also prevents neuron death and hindlimb paralysis rats subjected to α‐amino‐3‐hydroxy‐5‐isoxazolepropionate (AMPA)‐induced chronic excitotoxic degeneration. Here, we show tyrosine kinase receptor‐2 for (VEGFR2) is expressed the adult rat, its blockade impedes VEGF‐mediated protection...
Infection by the human immunodeficiency virus (HIV) can result in debilitating neurological syndromes collectively known as HIV-associated neurocognitive disorders. Although HIV coat protein gp120 has been identified a potent neurotoxin that enhances NMDA receptor function, exact mechanisms for this effect are not known. Here we provide evidence activates two separate signaling pathways converge to enhance NMDA-evoked calcium flux clustering receptors modified membrane microdomains. enlarged...
Spontaneous recovery after a stroke accounts for significant part of the neurological in patients. However limited, spontaneous is mechanistically driven by axonal restorative processes which several molecular cues have been previously described. We report acceleration preclinical model ischemia/reperfusion rats via single intracerebroventricular administration extracellular vesicles released from primary cortical astrocytes. used magnetic resonance imaging and confocal multiphoton...
Abstract Ischemic stroke is a leading cause of disability worldwide. There no simple treatment to alleviate ischemic brain injury, as thrombolytic therapy applicable within narrow time window. During the last years, ketogenic diet (KD) and exogenous administration ketone body β‐hydroxybutyrate (BHB) have been proposed therapeutic tools for acute neurological disorders both can reduce injury. However, mechanisms involved are not completely clear. We previously shown that D enantiomer BHB...
Neural progenitor cells (NPCs) of the subventricular zone proliferate in response to ischemic stroke adult mouse brain. Newly generated have been considered influence recovery following a stroke. However, mechanism underlying such protection is matter active study since it has thought that proliferating NPCs mediate their protective effects by secreting soluble factors promote rather than neuronal replacement penumbra. We tested hypothesis this mediated secretion multimolecular complexes...
Abstract Ischemic stroke is a significant global health issue, ranking fifth among all causes of death and leading cause serious long‐term disability. leads to severe outcomes, including permanent brain damage neuronal dysfunction. Therefore, decreasing preventing injuries caused by has been the focus therapeutic research. In recent years, many studies have shown that fluctuations in hormonal levels influence prognosis ischemic stroke. Thus, it relevant understand role hormones...
Vascular endothelial growth factor (VEGF) has long been connected to the development of tissue lesion following ischemic stroke. Contradictory findings either situate VEGF as a promoter large infarct volumes or potential attenuator damage due its well documented neuroprotective capability. The core this discrepancy mostly lies on substantial number pleiotropic functions driven by VEGF. Mechanistically, these effects are activated through several receptors for which various closely related...
VEGF (vascular endothelial growth factor) prevents neuronal death in different models of ALS (amyotrophic lateral sclerosis), but few studies have addressed the efficacy to protect motor neurons after onset symptoms, a critical point when considering as potential therapeutic target for ALS. We studied capability an excitotoxic challenge two spinal neurodegeneration rats induced by AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) administered either chronically with osmotic...