A5025718308- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Plant Gene Expression Analysis
- Plant Physiology and Cultivation Studies
- Genomics, phytochemicals, and oxidative stress
- Postharvest Quality and Shelf Life Management
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Plant Stress Responses and Tolerance
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- Infant Nutrition and Health
- Enzyme Catalysis and Immobilization
- Genetic factors in colorectal cancer
- Biochemical and biochemical processes
- Plant biochemistry and biosynthesis
- Prostate Cancer Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Plant Parasitism and Resistance
- Bioinformatics and Genomic Networks
Peking University Third Hospital
2014-2025
University of Oxford
2023-2025
Peking University
2014-2025
Nuffield Orthopaedic Centre
2023
Qingdao Institute of Bioenergy and Bioprocess Technology
2021-2022
Chinese Academy of Sciences
2021-2022
University of Lincoln
2022
University of Birmingham
2020-2021
Guizhou University
2021
Chongqing University
2007-2018
Transcriptomes are known to organize themselves into gene co-expression clusters or modules where groups of genes display distinct patterns coordinated synchronous expression across independent biological samples. The functional significance these is suggested by the fact that highly coexpressed tend be enriched in involved common functions and processes. While widely assumed reflect close regulatory proximity, validity this assumption remains unclear. Here we use a simple synthetic network...
The basic helix-loop-helix (bHLH) proteins are a large family of transcription factors that control various developmental processes in eukaryotes, but the biological roles most bHLH not very clear, especially tomato. In this study, PRE-like atypical gene was isolated and designated as SlPRE2 highly expressed immature-green fruits, moderately young leaves, flowers, mature-green fruits. To further research function SlPRE2, 35 S:PRE2 binary vector constructed transformed into wild type...
MADS-box genes have been reported to play a major role in the molecular circuit of developmental regulation. Especially, SEPALLATA (SEP) group central regulation ripening both climacteric and non-climacteric fruits. However, mechanisms underlying SEP fruits are still unclear. Here gene pepper, CaMADS-RIN, has cloned exhibited elevated expression at onset pepper. To further explore function an overexpressed construct was created transformed into inhibitor (rin) mutant tomato plants. Broad...
MADS-box genes have been proved to participate in a number of processes tomato development especially fruit ripening. In this study, we reported novel gene, SlMBP15, which is implicated According statistics, the ripening time SlMBP15-silenced delayed 2 4 days compared with wild-type. The accumulation carotenoid and biosynthesis ethylene fruits were decreased tomato. Genes related repressed remarkably. SlMBP15 can interact RIN, regulator affecting addition, generated dark green leaves plant...
Epithelial cancers are typically heterogeneous with primary prostate cancer being a typical example of histological and genomic variation. Prior studies tumour genetics revealed extensive inter intra-patient heterogeneity. Recent advances in machine learning have enabled the inference ground-truth single-nucleotide copy number variant status from transcript data. While these inferred SNV CNV states can be used to resolve clonal phylogenies, however, it is still unknown how faithfully...
<title>Abstract</title> Background Pancreatic cancer with liver metastasis (PCLM) has a very poor chance of long-term survival. There is lack effective prognostic markers that reflect the tumor microenvironment in those patients. Objective This study was performed to determine role systemic immune-inflammation index neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR) and platelet-to-lymphocyte (PLR) PCLM. Methods A retrospective analysis cases PCLM at our institution between...
Abstract Introduction: Risk stratification remains a key challenge in prostate cancer (PCa) management involves risk stratification, and identification of the subgroup patients at highest progressing from localised to metastatic disease is critical. Multiparametric MRI (mpMRI) PCa diagnostic pathway. By integrating clinical parameters, mpMRI radiomics spatial transcriptomics (ST), this novel “Radio-Spatial Genomics” platform offers an exciting opportunity identify radiomic features...
Abstract Introduction: Prostate cancer (PCa) exhibits significant intratumoral heterogeneity, driving a spectrum of phenotypes ranging from indolent disease to aggressive metastasis, challenging risk stratification and treatment. A key feature this heterogeneity is clonal diversity, encompassing both cells their interactions with the surrounding stromal microenvironment. Understanding dynamics influences on tumor progression crucial for identifying factors that contribute metastasis...
Abstract MADS-box transcription factors play important role in plant growth and development, especially floral organ identities. In our study, a gene SlGLO1 - tomato homeotic protein FBP1-like was isolated. Its tissue-specific expression profile analysis showed that highly expressed petals stamens. RNAi (RNA interference) repression of resulted abnormal phenotypes, including green with shorter size aberrant carpelloid -silenced lines are male sterile. Total chlorophyll content increased...
Abstract Introduction Immune cells and molecules are considered as clinical biomarkers potential targets for immunotherapy. Analyses of the composition peripheral blood hold promise providing a basis diagnosing prognosis lung cancer. In this study, we assessed correlations between immune cell subset profiles in disease patients with Methods One hundred thirteen cancer 99 age‐matched healthy people were enrolled study. The percentage count monocytes, neutrophils, T cells, B natural killer...
Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for prevention.
Xylose is the raw material for synthesis of many important platform compounds. At present, xylose commercially produced by chemical extraction. However, there are still some bottlenecks in extraction xylose, including complicated operation processes and substances introduced, leading to high cost synthesizing downstream compounds xylose. The current market price 8× that glucose, so using low-cost glucose as substrate produce can theoretically reduce 70%. Here, we designed a pathway...
Lacto-N-biose (LNB) is a member of the human milk oligosaccharide (HMO) family and synthesized via an enzymatic reaction in vitro with N-acetylglucosamine (GlcNAc) cofactors. In this study, LNB was using cell factory for first time. First, three modules were constructed Kluyveromyces lactis producing from lactose GlcNAc without addition Second, de novo pathway K. adding GlcNAc. Finally, transcriptional switch introduced into to reprogram its metabolic network improving flux GlcNAc-6-P...
Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR), indexes of systemic inflammation, have been associated with worse survival for many types cancer. The aim this study is to investigate the impact NLR PLR on overall (OS) explore value changes in treatment as a response indicator non-small cell lung cancer (NSCLC). A total 68 NSCLC patients Peking University Third Hospital were eligible retrospective analysis between April 2008 2015. pretreatment posttreatment all...
Abstract upa20 induces cell enlargement and hypertrophy development. In our research, overexpression of SlUPA-like , orthologous to severely affected the growth vegetative reproductive tissues. Wilted leaves curled upwardly sterile flowers were found in transgenic lines. Through anatomical analysis, palisade spongy tissues showed fluffy hypertrophic development plants. Gene expression analysis that GA responsive, biosynthetic signal transduction genes (e.g. GAST1 SlGA20OXs, SlGA3OXs SlGID1s...
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, precise molecular mechanisms linking Aβ deposition neurological are still unclear. Here we combine genome-wide transcriptional profiling insular cortex 3xTg-AD mice control littermates from early through late adulthood (2–14 months age), with behavioral biochemical in same animals identify determinants functional specifically...