A5089596395- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Plant Virus Research Studies
- Yersinia bacterium, plague, ectoparasites research
- Malaria Research and Control
- CRISPR and Genetic Engineering
- Viral Infections and Vectors
National AIDS Research Institute
2021-2023
Indian Council of Medical Research
2022
Orientia tsutsugamushi is responsible for causing scrub typhus (ST) and the leading cause of acute encephalitis syndrome (AES) in AES patients. A rapid sensitive method to detect on-site essential timely deployment control measures. In current study, we developed a rapid, sensitive, instrument-free lateral flow assay (LFA) detection based on CRISPR/Cas12a technology diagnosing ST (named LoCIST). The completed three steps: first, harnessing ability recombinase polymerase isothermal...
Scrub typhus infections caused by Orientiatsutsugamushi (OT), continue to remain underdiagnosed globally, due the lack of distinctive symptoms. The elusive nature Acute Encephalitis Syndrome (AES) outbreak in Gorakhpur, Uttar Pradesh that claimed numerous pediatric lives was driving force this study which involved serological diagnosis (IgM–ELISA), isolation OT cell culture, confirmation PCR, and characterization Sanger sequencing. In total, 12 out 36 patients were seropositive, 4 positive...