Hirawati Deval
A5086556056- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Congenital Diaphragmatic Hernia Studies
- Yersinia bacterium, plague, ectoparasites research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Herpesvirus Infections and Treatments
- Pneumonia and Respiratory Infections
- Plant Virus Research Studies
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Leptospirosis research and findings
- Viral Infections and Outbreaks Research
- Travel-related health issues
- Dengue and Mosquito Control Research
- COVID-19 Impact on Reproduction
- Plant Pathogens and Resistance
- Infectious Encephalopathies and Encephalitis
- Metal-Catalyzed Oxygenation Mechanisms
- Leprosy Research and Treatment
Regional Medical Research Centre
2019-2025
Regional Medical Research Centre
2020-2024
Baba Raghav Das Medical College
2016-2024
Indian Council of Medical Research
2016-2024
Government of India
2021-2023
Regional Medical Research Center
2021
ICMR-National Institute of Virology
2016-2020
Deen Dayal Upadhyaya Gorakhpur University
2018-2020
Ministry of Health and Family Welfare
2016
BackgroundThe first national severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in India, done May–June, 2020, among adults aged 18 years or older from 21 states, found a SARS-CoV-2 IgG antibody seroprevalence of 0·73% (95% CI 0·34–1·13). We aimed to assess the more recent nationwide general population India.MethodsWe did second household individuals 10 same 700 villages wards within 70 districts India that were included serosurvey. Individuals younger than and...
BackgroundEarlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 0.73% May–June 2020 and 7.1% August–September 2020. A third serosurvey was conducted between December January 2021 to estimate the SARS-CoV-2 infection among general population healthcare workers (HCWs) India.MethodsThe same 70 districts as first second serosurveys. For each district, at least 400 individuals aged ≥10 years from 100 HCWs subdistrict-level health...
The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution virus clades and variants circulating different parts India between January August 2020. NPS/OPS from representative positive states union territories were collected every month through VRDLs country analyzed using next-generation sequencing. Epidemiological analysis 689 SARS-CoV-2 clinical samples revealed GH GR to be predominant northern...
Dengue fever is an endemic disease in India, transmitted by infected mosquito bite. In the number of concurrent infections and circulation multiple dengue virus (DENV) serotypes has increased recent decades. Molecular surveillance among DENV serotype important to keep track circulating serotypes, evolutionary changes, key mutations that can alter diagnostics. The current study included patients admitted for Eastern Uttar Pradesh (E-UP) region during 2018-2019. genetic characterization was...
Seasonal outbreaks of acute encephalitis syndrome (AES) with high fatality have been occurring in Gorakhpur, Uttar Pradesh, India, for several years. We conducted investigations during the 2016 outbreak to identify etiology.We included 407 hospitalized AES patients cerebrospinal fluid pleocytosis (>5 cells/mm) our study. These were clinically examined; their blood and samples collected investigated scrub typhus (ST), Japanese virus (JEV), dengue spotted fever group Rickettsia by serology...
Background Recent studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reveal that Omicron variant BA.1 and sub-lineages have revived the concern over resistance to antiviral drugs vaccine-induced immunity. The present study aims analyze clinical profile genome characterization of SARS-CoV-2 in eastern Uttar Pradesh (UP), North India. Methods Whole-genome sequencing (WGS) was conducted for 146 samples obtained from individuals who tested disease 2019 (COVID-19) positive...
Orientia tsutsugamushi is responsible for causing scrub typhus (ST) and the leading cause of acute encephalitis syndrome (AES) in AES patients. A rapid sensitive method to detect on-site essential timely deployment control measures. In current study, we developed a rapid, sensitive, instrument-free lateral flow assay (LFA) detection based on CRISPR/Cas12a technology diagnosing ST (named LoCIST). The completed three steps: first, harnessing ability recombinase polymerase isothermal...
Background: Repeated cross-sectional serosurveys in the same geographic area establish trend of evolving pandemic. We present findings third round a national serosurvey to estimate seroprevalence SARS-CoV-2 infection among general population and health care workers India. Methods: conducted population-based between Dec 18, 2020 Jan 6, 2021 700 villages or wards from 70 districts 21 states across India, which were selected for first second serosurveys. enrolled each district, at least 400...
Globally, the COVID-19 pandemic and its prevention control policies have impacted maternal child health (MCH) services. This study documents challenges faced by patients in accessing MCH services, experiences of care providers delivering those services during outbreak, explicitly focusing on lockdown period India.A cross-sectional (rapid survey) was conducted 18 districts from 6 states India March to June, 2020. The sample size included 540 patients, gynaecologists, paediatricians, district...
Acute respiratory infections (ARIs) are a serious public health concern across the world, causing considerable morbidity and mortality. Every year, around 13 million children under age of five die. Approximately 95% them from developing nations, ARIs responsible for one-third all deaths. Human Metapneumovirus (hMPV) is one causative agents associated with tract infections. There lack information about hMPV eastern region Uttar Pradesh. At Indian Council Medical Research- Regional Research...
Uttar Pradesh is the densely populated state of India and sixth highest COVID-19 affected with 22,904 deaths recorded on November 12, 2021. Whole-genome sequencing (WGS) being used as a potential approach to investigate genomic evolution severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In this study, total 87 SARS-CoV-2 genomes-49 genomes from first wave (March 2020 February 2021) 38 second 2021 July Eastern (E-UP) were sequenced analyzed understand its evolutionary...
India has a tribal population of 8.6%. Health concerns the high-altitude in play vital role overall socio-economic development and health transformation country. Therefore, aim this study was to determine current problems among Lahaul Spiti district Himachal Pradesh.
Dengue (DEN) is the most common cause of mosquito-borne endemic viral diseases in tropical and subtropical countries. DEN outbreaks associated with multiple dengue virus (DV) serotypes have been regularly reported different parts India. This study was done during 2015 to 2016 UP Bihar where DEN-2 found as only prevalent serotype. DV-2 serotype amplified serotype-specific reverse-transcription polymerase chain reaction from sera 210 (65.21%) out 322 DV NS1 antigen-positive patients. Further...
Objective To determine the Japanese encephalitis (JE)-associated long-term functional and neurological outcomes, extent of reduced social participation predictors poor outcomes among paediatric JE survivors. Design A retrospective cohort study. Setting Laboratory-confirmed JE-positive cases (<16 years age) hospitalised at ward Baba Raghav Das Medical College, Gorakhpur, India, between 1 January 2017 31 December 2017, were followed up after 6–12 months hospital discharge. Participants 126...
Abstract The Eastern Uttar Pradesh region of India is known for its endemicity acute encephalitis syndrome (AES). Decades research have established that Orientia tsutsugamushi , a causative scrub typhus, substantial contributor (>60%) the AES cases besides other aetiology, but additional factors in remaining proportion are still unidentified. Rickettsial infections challenging to diagnose clinical settings due overlapping symptoms, absence definitive indicators, low index suspicion, and...
Background: Seasonal outbreaks of acute encephalitis syndrome (AES) have been reported especially in the pediatric population with a high case fatality rate Eastern Uttar Pradesh, India. Orientia tsutsugamushi (OT) is causative agent scrub typhus that has recently identified as major cause AES. However, specific genotypes OT responsible for AES cases this region are not known. Therefore, present study was undertaken to understand molecular epidemiology prevailing endemic Pradesh Methods: The...
Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles viruses vary by region season. Due to limited information the population’s vulnerability, we conducted hospital-based surveillance Eastern Uttar Pradesh. Throat nasal swabs were collected from outpatients inpatients Department Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 April 2023. A total 943 samples aged 1 60 months tested...
Abstract Rickettsia and Anaplasma are bacteria that can be transmitted by hematophagous arthropods such as ticks infesting animals in close proximity to humans. The main objective of the present study was investigate abundance common tick species domestic presence populations. Adult were collected from rural areas screened molecular detection bacterial DNA for these two genera bacteria. A total 1,778 adult ixodid specimens 200 cattle, buffaloes, goats, 40 dogs. collection consisted four...
Background: Repeated cross-sectional serosurveys in the same geographic area establish trend of evolving pandemic. We present findings third round a national serosurvey to estimate seroprevalence SARS-CoV-2 infection among general population and health care workers India. Methods: conducted population-based between Dec 18, 2020 Jan 6, 2021 700 villages or wards from 70 districts 21 states across India, which were selected for first second serosurveys. enrolled each district, at least 400...