A5101529478- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Parkinson's Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Vector-borne infectious diseases
- Respiratory viral infections research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pneumonia and Respiratory Infections
- Neuroendocrine regulation and behavior
- Infectious Encephalopathies and Encephalitis
- Yersinia bacterium, plague, ectoparasites research
- Dengue and Mosquito Control Research
- Migraine and Headache Studies
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Plant Disease Management Techniques
- Media Influence and Health
- Racial and Ethnic Identity Research
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- School Leadership and Teacher Performance
- Adenosine and Purinergic Signaling
Regional Medical Research Centre
2019-2025
Children's Hospital of Philadelphia
2025
Regional Medical Research Centre
2020-2024
Zunyi Medical University
2023
Institute of Medical Sciences
2023
Baba Raghav Das Medical College
2022-2023
Government of India
2023
G.S. Science, Arts And Commerce College
2023
King George's Medical University
2023
Central Drug Research Institute
2000-2016
Dengue fever is an endemic disease in India, transmitted by infected mosquito bite. In the number of concurrent infections and circulation multiple dengue virus (DENV) serotypes has increased recent decades. Molecular surveillance among DENV serotype important to keep track circulating serotypes, evolutionary changes, key mutations that can alter diagnostics. The current study included patients admitted for Eastern Uttar Pradesh (E-UP) region during 2018-2019. genetic characterization was...
Adult hippocampal neurogenesis is directly involved in regulation of stress, anxiety, and depression that are commonly observed nonmotor symptoms Parkinson's disease (PD). These do not respond to pharmacological dopamine replacement therapy. Excitotoxic damage neuronal cells by N-methyl-d-aspartate (NMDA) receptor activation also a major contributing factor PD development, but whether it regulates yet unexplored. Herein, for the first time, we studied effect MK-801, an NMDA antagonist, on...
This study was undertaken to investigate the nitric oxide synthase (NOS) activity in striatum following 6-hydroxydopamine (6-OHDA) induced neurodegeneration rats. Constitutive NOS (cNOS) remained unaltered at 3, 7 and 14 days after lesion, while a 43% 45% decrease observed 30 50 days, respectively. Inducible (iNOS) detected only on 3rd day lesion not subsequent or control striatum. NG-nitro-L-arginine methyl ester (L-NAME) pretreatment blocked amphetamine-induced rotations inhibited iNOS...
Objective- The present study was undertaken to evaluate the alteration in peripheral neuronal nitric oxide synthase (NOS) activity Parkinson's disease patients. Therefore, basal nitrite content PMNs, platelets and plasma of PD control Indian population were evaluated. Materials methods- We estimated nitrite, (NO) metabolite, neutrophils (PMNs), L-dopa treated (PD) also measured catalase, superoxide dismutase (SOD) glutathione peroxidase (GPx) PMNs. Results- observed a significant increase...
The present study was undertaken to elucidate the role of circulating neutrophils if any in oxidative stress migraine by evaluating free radical generation and activities enzymatic antioxidants blood 55 patients with 60 healthy controls. Free assessed flow cytometry, while activity catalase, superoxide dismutase (SOD) glutathione peroxidase (GPx) estimated polymorphonuclear (PMNs) standard procedures. Platelet SOD also measured. No significant change found GPx patients. Univariate analysis...
Objective.—To investigate blood nitrite levels after migraine attacks and to assess whether or not the change in nitric oxide observed during acute persist attacks. Background.—Involvement of has been suggested initiation migraine. Recent studies have shown alteration platelet response Methods.—Patients with aura patients without were included study. The study was conducted on 50 90 healthy controls. Blood from collected at least 7 ± 0.8 days last attack Nitrite polymorphonuclear leukocytes,...
Objective To determine the Japanese encephalitis (JE)-associated long-term functional and neurological outcomes, extent of reduced social participation predictors poor outcomes among paediatric JE survivors. Design A retrospective cohort study. Setting Laboratory-confirmed JE-positive cases (<16 years age) hospitalised at ward Baba Raghav Das Medical College, Gorakhpur, India, between 1 January 2017 31 December 2017, were followed up after 6–12 months hospital discharge. Participants 126...
The clinico-epidemiological pattern of malarial infection in a cohort pregnant women and infants was analysed during malaria epidemic (1997-1998). subjects were all members tribal communities an isolated almost inaccessible area central India. Overall, 151 (55%) the 274 investigated found to have infections at some time study, with Plasmodium falciparum predominating (88% infections). All investigated, whether primigravidae (42% infected), secundigravidae (68%) or multigravidae (54%), great...
Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles viruses vary by region season. Due to limited information the population’s vulnerability, we conducted hospital-based surveillance Eastern Uttar Pradesh. Throat nasal swabs were collected from outpatients inpatients Department Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 April 2023. A total 943 samples aged 1 60 months tested...
Fast dissolving tablets are the newer form of drugs which do not require water for their intake. They chewable and very easy to take patients who have difficulty in taking or capsules. These can be dissolved into mouth within a matter seconds. The release drug takes place with help saliva immediately show effect. given pediatric, geriatric bedridden problem swallowing tablets. As directly disintegrates mouth, so these undergo first pass metabolism due chances liver dysfunction also...
To highlight and assess the impact of intervention tools used by Indian Council Medical Research (ICMR) against COVID19 associated infodemic in world's largest democratic country, India.It is a retrospective cross sectional study. The ICMR's multi-pronged strategy to address during pandemic has been assessed through analysis print media reportage social engagements.The interventions was using cloud mappers like MediaCloud Meltwater keywords. data analysed terms reportage, theme reportage. A...
Protective effects of NOS inhibitors and free radical scavengers in cerebral ischemia are well documented. The present study was undertaken to determine the possible inhibition on brain antioxidants. Levels both enzymatic [glutathione peroxidase (GPx), catalase superoxide dismutase (SOD)] non-enzymatic [reduced glutathione (GSH)] antioxidants following nitric oxide synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME), D-NAME or 7-nitro-indazole (7-NI) have been investigated. activity...
AbstractNitric oxide (NO) mediated oxidative damage may be involved in the pathogenesis of neuronal degeneration motor neuron disease (MND). The present study was undertaken to evaluate role NO and stress MND by estimating nitrite malondialdehyde (MDA) levels cerebrospinal fluid (CSF) 22 patients 20 control subjects suffering from neurological disorders not known affect metabolism. There no significant change CSF MDA MND. did have any correlation with age, duration illness, or severity...
Culex quinquefasciatus (C. quinquefasciatus) is found in tropical and warm temperate regions can transmit several viral diseases like Elephantiasis or Filariasis, West Nile fever, St. Louis encephalitis, Japanese encephalitis causes millions of deaths every year. Long term use synthetic pesticides to control mosquitoes, has led the emergence insecticide resistant vector, ecological imbalance, harm mammals, water contamination, toxicity non-target organisms residual effects. Therefore, plant...
Objective: An increased global dependence on digital screen use has resulted in a tremendous increase screen-related ocular complaints such as dryness, strain, burning sensation, grittiness, and transient blurring. This study aims to focus the correlation between duration of exposure dry eyes among young medical students with help combination questionnaire based subjective symptoms time further tests confirm those having symptoms. Numerous mechanisms have been mentioned screen-associated...