A5010302103- HIV/AIDS Research and Interventions
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Intimate Partner and Family Violence
- Global Maternal and Child Health
- Agricultural Science and Fertilization
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Genital Health and Disease
- Wastewater Treatment and Reuse
- Vaccine Coverage and Hesitancy
- Ethics in Clinical Research
- Plant Micronutrient Interactions and Effects
- COVID-19 epidemiological studies
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Poverty, Education, and Child Welfare
- Demographic Trends and Gender Preferences
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Cervical Cancer and HPV Research
- Plant nutrient uptake and metabolism
National AIDS Research Institute
2014-2023
Department of Biotechnology
2018-2023
Ganesh Shankar Vidyarthi Memorial Medical College
2023
Indian Council of Medical Research
2004-2023
Jamia Millia Islamia
2018-2023
Savitribai Phule Pune University
2022-2023
University of Nebraska–Lincoln
2023
National Institute of Epidemiology
2021
Bihar Agricultural University
2020
National Institute Of Veterinary Epidemiology And Disease Informatics
2020
Background & objectives: Population-based seroepidemiological studies measure the extent of SARS-CoV-2 infection in a country. We report findings first round national serosurvey, conducted to estimate seroprevalence among adult population India. Methods: From May 11 June 4, 2020, randomly sampled, community-based survey was 700 villages/wards, selected from 70 districts 21 States India, categorized into four strata based on incidence reported COVID-19 cases. Four hundred adults per...
BackgroundThe first national severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in India, done May–June, 2020, among adults aged 18 years or older from 21 states, found a SARS-CoV-2 IgG antibody seroprevalence of 0·73% (95% CI 0·34–1·13). We aimed to assess the more recent nationwide general population India.MethodsWe did second household individuals 10 same 700 villages wards within 70 districts India that were included serosurvey. Individuals younger than and...
BackgroundEarlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 0.73% May–June 2020 and 7.1% August–September 2020. A third serosurvey was conducted between December January 2021 to estimate the SARS-CoV-2 infection among general population healthcare workers (HCWs) India.MethodsThe same 70 districts as first second serosurveys. For each district, at least 400 individuals aged ≥10 years from 100 HCWs subdistrict-level health...
Abstract Plant growth and resilience require balancing an inherently oxidative metabolism with powerful antioxidant systems that help maintain homeostasis. When the environment changes, reactive oxygen species are potent indicators of change, allowing adaptation through re-balancing systems. A large body evidence supports use exogenously applied antioxidants to improve both plant their stress. Notably, some phenotypic effects similar upon application chemically diverse antioxidants, while...
Domestic violence (DV) is reported by 40% of married women in India and associated with substantial morbidity. An operational research definition therefore needed to enhance understanding DV epidemiology inform interventions measures. To arrive at a culturally-tailored definition, we aimed better understand how definitions provided the World Health Organization 2005 Protection Women from Violence Act match perceptions behaviors constituting among Indian community. Between September 2012...
Abstract Little is known about the interactive effects of exogenous nitric oxide (NO) and abscisic acid (ABA) on nitrogen (N) metabolism related changes at molecular biochemical levels under drought stress. The present study highlights independent combined effect NO ABA (grouped as “nitrate agonists”) expression profiles representative key genes to be involved in N-uptake assimilation, together with proline metabolism, N–NO enzyme’s activity nutrient content polyethylene glycol (PEG) treated...
Two phases of CD4+ T-cell increases are seen soon after potent antiretroviral therapy (ART) is initiated. In this 72-week analysis 101 subjects with sustained viral suppression, we estimate the inflection point between 2 to be 10 weeks treatment initiation. Higher pretreatment HIV-1 RNA levels were associated steeper initial increases, likely reflecting greater redistribution cells from lymphoid tissue peripheral blood compartment.
Abstract Human immunodeficiency virus (HIV)‐infected women in India and other developing country settings are living longer on antiretroviral therapy, yet their risk for human papillomavirus (HPV)‐induced cervical cancer remains unabated because of lack cost‐effective accurate secondary prevention methods. Visual inspection after application dilute acetic acid the cervix (VIA) has not been adequately studied against current standard: conventional cytology (Pap smears) among HIV‐infected...
A randomized, double-blind, placebo controlled phase I trial.The trial was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and immunogenicity of prime-boost vaccination regimens with either 2 doses ADVAX, a DNA vaccine containing Chinese HIV-1 subtype C env gp160, gag, pol nef/tat genes, as prime TBC-M4, recombinant MVA encoding Indian RT, rev, tat, nef boost Group or 3 TBC-M4 alone B participants. Out 16 participants each group, 12 received candidates 4 placebos.Both...
In India, substantial efforts have been made to increase awareness about HIV/AIDS among female sex workers (FSWs). We assessed the impact of regarding safe in a cohort FSWs by studying trends HIV prevalence, sexually transmitted diseases (STDs), and risk behaviors measured from 1993 2002 Pune, India. A total 1359 attending 3 STD clinics were screened for infection, data on demographics, sexual behaviors, past current STDs obtained. The overall prevalence was 54%. Not being married (adjusted...
A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses antibodies in nonhuman primates. In this randomized, dose escalation phase I trial, HIV-uninfected healthy volunteers (50 Europe, 30 India) received single intramuscular injection tgAAC09 at 3 × 109 DNase resistant particles (DRP)...
Adherence to ART is a patient specific issue influenced by variety of situations that may encounter, especially in resource-limited settings. A study was conducted understand factors and influencers adherence their follow ups among patients attending centres Maharashtra, India.Between January March 2009, barriers 32 at three selected functioning under national roll-out programme India, were studied using qualitative methods. Consenting interviewed assess adherence. Constant comparison method...
Background The objectives of this cross-sectional study were to determine the prevalence HIV and sexually transmitted infections (STI) in Hijras (self-identified transgenders South Asia), associated risk factors, compare with that heterosexual men having sex (MSM) Pune, India, between 1993 2002. Methods After informed consent, individuals attending 3 STI clinics administered a questionnaire regarding their demographic, socioeconomic, sexual behaviors. Blood samples collected for diagnosis....
The high prevalence of domestic violence (DV) among married women in India and associated negative health repercussions highlight the need for effective prevention strategies tools to measure efficacy such interventions. Literature supporting differing manifestations DV by culture underscores a culturally-tailored scale more effectively Indian context. We therefore aimed develop validate tool, Family Violence Control Scale (IFVCS), through mixed-methods study. psychometric development IFVCS...
The high risk of experiencing domestic violence (DV) among married women in India who reside slum communities underscores the need for effective, evidence-based, and culturally-tailored primary prevention. To inform such DV prevention strategies this population, we herein aimed to identify correlates experience early marriage. Utilizing a cross-sectional design, potential were explored geographically-clustered random sample 100 recently-married residing slums Pune, India. In multivariable...
To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics Pune, India, who deny history commercial sex work (CSW).Cross-sectional.From 1993 to 2002, 2376 3 STI Pune were offered screening. Women denied CSW included (n = 1020).Of 1020 women, 21% infected. The annual increased from 14% 29% 2001-2002 (P < 0.001). change time was paralleled by clinic visitor characteristics; later periods, older, more...
Background Prevalence estimates of cervical intraepithelial neoplasia (CIN) among HIV-infected women in India have been based on cytology, which may underestimated true disease burden. We sought to better establish prevalence and evaluate risk factors CIN Pune, using colposcopy histopathology as diagnostic tools. Methodology Previously unscreened, non-pregnant underwent cancer screening evaluation including standardized by a gynecologist. Histopathologic confirmation was conducted consenting...
Abstract Background Empowering female sex workers (FSWs) through women controlled HIV prevention option has been in focus globally. FSWs are important target for oral pre exposure prophylaxis (PrEP). A multi-centric qualitative study was conducted to explore the FSWs’ willingness use PrEP India. Methods Seventy three interviews and 02 group discussions were at 3 high prevalent states India during 2013–14. Study explored issues around PrEP. The approved by respective institutional ethics...
Summary: Unlike commercial sex workers and patients attending sexually transmitted infection (STI) clinics, married couples are not typically targeted for HIV risk reduction programs in India. Thus, partners of HIV-infected persons at particularly high infection. Between September 2002 November 2004, 457 HIV-1 sero-discordant, were enrolled a one-year prospective study transmission Pune, The incidence among uninfected was 1.22 per 100 person-years (95% CI 0.45-2.66), which is much lower than...