A5101576175- Analytical Chemistry and Chromatography
- Spectroscopy and Chemometric Analyses
- Crystallization and Solubility Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Analytical Methods in Pharmaceuticals
- Thermochemical Biomass Conversion Processes
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Photovoltaic System Optimization Techniques
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- solar cell performance optimization
- Iron and Steelmaking Processes
- Molecular spectroscopy and chirality
- Coal Combustion and Slurry Processing
- Chemical and Physical Properties in Aqueous Solutions
- Drug Solubulity and Delivery Systems
- Advanced Chemical Sensor Technologies
- Synthesis of β-Lactam Compounds
- Electric Power System Optimization
- Pharmacogenetics and Drug Metabolism
- Water Quality Monitoring and Analysis
- Pigment Synthesis and Properties
- Coal and Its By-products
Shandong University of Political Science and Law
2024
Shanghai Changzheng Hospital
2021-2023
Nanjing Normal University
2022-2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2001-2015
Wuhan University of Technology
2011
Peking University
2010
Merck (Singapore)
2006
University of Illinois Urbana-Champaign
2006
National University of Singapore
2006
Recent advances in situ measurement technology and automation of batch crystallizers have enabled the development crystallization recipes which desired supersaturation profile is followed by feedback control. This paper describes a new approach for following setpoints antisolvent crystallizations that easy to implement tried crystallization. Simulations application proprietary drug compound demonstrate how this combination process measurements enables rapid processes pharmaceutical industry.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNoninvasive method for monitoring ethanol in fermentation processes using fiber-optic near-infrared spectroscopyAnna G. Cavinato, David M. Mayes, Zhihong. Ge, and James B. CallisCite this: Anal. Chem. 1990, 62, 18, 1977–1982Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://doi.org/10.1021/ac00217a015RIGHTS & PERMISSIONSArticle Views1152Altmetric-Citations116LEARN ABOUT...
In situ Raman spectroscopy was used to determine the rate of polymorph turnover for MK-A, a multipolymorphic compound in development at Merck Research Laboratories. The known crystal forms MK-A include four anhydrous polymorphs, two hydrates, and numerous solvates. penultimate pure steps this process involve coupling reaction generate mixture followed by desired polymorph, form A. This paper summarizes experiments measure kinetics from all relevant Additionally, reversion A undesired were...
A practical, one-pot process for the preparation of beta-keto amides via a three-component reaction, including Meldrum's acid, an amine, and carboxylic has been developed. Key to development efficient, high-yielding was in-depth understanding mechanism multistep process. Kinetic studies were carried out online IR monitoring subsequent principal component analysis which provided means profiling concentration both anionic free acid forms adduct 6 in real time. These studies, presence absence...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNoninvasive Spectroscopy for Monitoring Cell Density in a Fermentation ProcessZhihong. Ge, Anna G. Cavinato, and James B. CallisCite this: Anal. Chem. 1994, 66, 8, 1354–1362Publication Date (Print):April 15, 1994Publication History Published online1 May 2002Published inissue 15 April 1994https://pubs.acs.org/doi/10.1021/ac00080a023https://doi.org/10.1021/ac00080a023research-articleACS PublicationsRequest reuse permissionsArticle...
Potential genotoxic impurities (PGI) are chemical compounds that could potentially damage DNA and lead to mutation. Controlling the occurrence of PGIs in active pharmaceutical ingredients (APIs) poses a big challenge for chemists, as levels these must be reduced well below amounts required other types less toxic impurities. In situations where formation cannot avoided, an ideal solution would allow complete removal after synthesis is complete, example, by recrystallization, preparative...
A mobile HPLC reaction monitoring tool consisting of a cart-mounted microfluidic instrument equipped with tethered, automated sampling and dilution module is described. Several examples the use for carrying out progress analysis are presented. Reaction aliquot size typically only few microliters, allowing extensive sample from small volume reactions. quenching possible, adjustable, suitable precision accuracy even at hundredfold dilution. capillary chemically inert stainless steel fritted...
Abstract Optical pure (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid, a chiral crown ether, was successfully used as selector for the stereoisomeric separation of numerous real pharmaceutical compounds. Both practical and mechanistic aspects were described. Effects concentration under different pH values BGE discussed. Chiral recognition enantiomeric compounds with acid investigated through model using CE infrared spectroscopic techniques. Relations between enantioselectivity ether...
Designation and justification of an Active Pharmaceutical Ingredient Starting Material (API SM) is important aspect the drug development commercialization process defines point at which GMP manufacturing starts (ICH Q7: Good Manufacturing Practice Guide for Ingredients). In 2014, API SM Working Group International Consortium Innovation & Quality in Development (IQ or IQ), composed representatives from Analytical Leadership Groups, published two manuscripts on SMs that provided (1) a review...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic Aspects of the Stereospecific Interaction for Aminoindanol with a Crown Ether ColumnRichard A. Thompson, Zhihong. Ge, Nelu. Grinberg, Dean. Ellison, and Patricia. TwayCite this: Anal. Chem. 1995, 67, 9, 1580–1587Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://pubs.acs.org/doi/10.1021/ac00105a017https://doi.org/10.1021/ac00105a017research-articleACS PublicationsRequest...
Abstract Etoricoxib (5‐chloro‐6′‐methyl‐3[4‐(methanesulfonyl)phenyl]‐2,3′‐bipyridine) is a highly active and selective cyclo‐oxygenase II inhibitor. A single, stability‐indicating HPLC method has been developed validated for both the impurity quantitative analysis of etoricoxib. Method development incorporated optimization stationary phase, pH, temperature, mobile phase composition resolution thirteen process impurities three major degradation products. Further pH was aided by use DryLab®,...
Abstract A novel approach for the potential on‐line determination of enantiomeric excess (ee) an M3 antagonist drug substance combining attenuated total reflectance infrared (ATR‐IR) spectroscopy, guest‐host complexes, and chemometric data analysis is described. Chiral recognition through a formation diastereomeric complexes was measured by ATR‐IR. Small changes on IR spectra reflect interaction between guest (M3) host (chiral selector). These are as function enantiomer excess. The standard...