A5107636340- Advanced Drug Delivery Systems
- Proteoglycans and glycosaminoglycans research
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Clay minerals and soil interactions
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Curcumin's Biomedical Applications
- Dysphagia Assessment and Management
- DNA and Nucleic Acid Chemistry
- Dendrimers and Hyperbranched Polymers
- Voice and Speech Disorders
- Immunotherapy and Immune Responses
- Surfactants and Colloidal Systems
- Bone Tissue Engineering Materials
- Glycosylation and Glycoproteins Research
- Polysaccharides Composition and Applications
- Therapeutic Uses of Natural Elements
- Analytical Chemistry and Chromatography
University of Naples Federico II
2015-2024
Center for Advanced Biomaterials for Healthcare
2023-2024
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2020-2021
Federico II University Hospital
2019
Istituto Nazionale Biostrutture e Biosistemi
2015-2017
National Research Council
2010
Italian Institute of Technology
2010
Abstract Combination chemotherapy by means of two or more drugs is prone to suppressing discouraging the inception multidrug resistance, exploiting fact that diverse act in different points cellular cycle amplifying tumor cells. For example, combination gemcitabine (GMC) with quercetin (QCT) showed a synergistic effect inhibiting migration pancreatic cancer Consequently, herein GMC and QCT have been loaded within biodegradable nanoparticles (NPs) based on poly(lactic‐co‐glycolic acid),...
Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed investigate the features affecting microscopic properties of gels, which determine their macroscopic capability control/sustain protein release. Results showed that HA hampers water-poloxamer...
Trans-resveratrol, a polyphenol extracted from Vitis vinifera, has different beneficial effects following its administration on the skin. Here potential use of binary systems to enhance in vitro and vivo activity trans-resveratrol was investigated. Thus aqueous solubility investigated presence growing concentrations polyethylene glycol (PEG) or β-cyclodextrin (βCD) as solubilizing excipients. Then, solid dispersion with PEG inclusion complexes trans-resveratrol/βCD were prepared...
The goal of this study was to produce and characterize the scaffolds by combining advantages both natural synthetic polymers for engineering fibro-cartilaginous tissues. Porous three-dimensional composite were produced based on glycosaminoglycans hyaluronic acid (HYAFF11) reinforced with polycaprolactone. mechanical properties evaluated as a function time compared those seeded human chondrocytes (constructs) cultured in vitro up 6 weeks. had porosity 68% interconnected macropores average...
Computational techniques, and in particular molecular dynamics (MD) simulations, have been successfully used as a complementary technique to predict analyse the structural behaviour of nucleic acids, including peptide acid- (PNA-) RNA hybrids. This study shows that 7-base long PNA seed region miR-509-3p, one miRNAs involved posttranscriptional regulation CFTR disease-gene Cystic Fibrosis, bearing suitable functionalization at its N- C-ends aimed improving resistance nucleases cellular...
Nanoparticles (NPs) coated with hyaluronic acid (HA) seem to be increasingly promising for targeted therapy due HA chemical versatility, which allows them bind drugs of different natures, and their affinity the transmembrane receptor CD-44, overexpressed in tumor cells. However, an essential aspect clinical use NPs is formulation stability over time. For these reasons, analytical techniques capable characterizing physico-chemical properties are needed. In this work,...