A5032538330- Sperm and Testicular Function
- Immune cells in cancer
- Reproductive Biology and Fertility
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Reproductive Health and Technologies
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- Trypanosoma species research and implications
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Diabetes Treatment and Management
- Synthesis and Catalytic Reactions
- Immune Cell Function and Interaction
- Chemical Synthesis and Analysis
- Neurogenetic and Muscular Disorders Research
- Genetics, Bioinformatics, and Biomedical Research
- Phagocytosis and Immune Regulation
- Renin-Angiotensin System Studies
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Click Chemistry and Applications
- Amyotrophic Lateral Sclerosis Research
Centre for Genomic Regulation
2021
VIB-UGent Center for Inflammation Research
2016
Vrije Universiteit Brussel
2011-2016
VIB-VUB Laboratory Myeloid Cell Immunology
2013
University of Copenhagen
2011
Infertile males with varicocele have the highest percentage of sperm cells damaged DNA, compared to other infertile groups. Antioxidant treatment is known enhance integrity DNA; however, there are no data on effects in patients. We thus investigated potential benefits antioxidant specifically grade I males. Twenty patients were given multivitamins (1500 mg L-Carnitine, 60 vitamin C, 20 coenzyme Q10, 10 E, 200 μg B9, 1 B12, zinc, 50 selenium) daily for three months. Semen parameters including...
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation variant-specific surface glycoprotein (VSG) and a highly active endocytosis recycling coat efficiently delay killing mediated by anti-VSG antibodies. Consequently, conventional VSG-specific intact immunoglobulins are non-trypanocidal in absence complement. In sharp contrast, monovalent antigen-binding...
Varicocele is one of the most common causes low semen quality, which reflected in high percentages sperm cells with fragmented DNA. While varicocelectomy usually performed to ameliorate a patient’s fertility, its impact on DNA integrity case subclinical varicocele poorly documented. In this study, multiple fragmentation analyses (TUNEL, SCD, and SCSA) were samples from sixty infertile patients (15 clinical varicoceles, 19 varicoceles after surgical treatment, 16 10 treatment). TUNEL, SCSA...
Two synthetic routes for the synthesis of amino-triazolodiazepine (Ata) scaffolds are presented. The scope both these proceeding through key intra- and intermolecular Huisgen cycloaddition reactions is discussed. replacement His-Pro dipeptide segment in angiotensin IV by mimetic Ata-Gly subsequent biological evaluation two inhibitory enzyme assays validated use Ata moiety as a His mimic given equipotency peptidic analogs.
Intracerebroventricular injection of angiotensin IV, a ligand insulin-regulated aminopeptidase (IRAP), has been shown to improve cognitive functions in several animal models. Consequently, IRAP is considered potential target for treatment disorders. To identify nonpeptidic inhibitors, we adapted an established enzymatic assay based on membrane preparations from Chinese hamster ovary cells and synthetic peptide-like substrate high-throughput screening purposes. The 384-well microplate-based...
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease characterized by the selective death of motor neurons. Disease pathophysiology complex and not yet fully understood. Higher gene expression inositol 1,4,5-trisphosphate receptor 2 (ITPR2), encoding IP3 (IP3R2), was detected in sporadic ALS patients. Here, we demonstrate that IP3R2 also increased spinal cords mice. Moreover, an increase observed other models chronic acute neurodegeneration. Upregulation...
The insulin-regulated aminopeptidase (IRAP) is expressed in several cell types, where it mainly located specialized secretory endosomes that are quickly recruited to the surface upon type-specific activation. Here we describe for first time expression and subcellular distribution of IRAP macrophages.IRAP mRNA expression, protein presence at was investigated by real-time polymerase chain reaction (PCR), Western blot [(3)H]IVDE77 binding, respectively.IRAP increased interferon-γ (IFN-γ)...