A5041220502- Synthesis and Properties of Aromatic Compounds
- Axial and Atropisomeric Chirality Synthesis
- Photochromic and Fluorescence Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Molecular spectroscopy and chirality
- Oxidative Organic Chemistry Reactions
- Analytical Methods in Pharmaceuticals
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Analysis
- Surface Chemistry and Catalysis
- Synthetic Organic Chemistry Methods
- Drug Solubulity and Delivery Systems
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Radiopharmaceutical Chemistry and Applications
- Chemical synthesis and alkaloids
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Environmental Chemistry and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Vanadium and Halogenation Chemistry
- Supramolecular Self-Assembly in Materials
- Alkaloids: synthesis and pharmacology
Osaka University
2021-2025
Suez Canal University
2019-2025
Agricultural Research Center
2025
Sanken Electric (Japan)
2022-2024
Osaka Research Institute of Industrial Science and Technology
2024
University of Mosul
1990-2023
Universiti Sains Malaysia
2021
Jordan University of Science and Technology
1997
Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molecular cores, facilitating complex transformations and minimizing resource-intensive synthesis. This review provides a comprehensive overview...
Abstract Traditional optimization methods using one variable at a time approach waste and chemicals assume that different parameters are independent from another. Hence, simpler, more practical, rapid process for predicting reaction conditions can be applied to several manufacturing environmentally sustainable processes is highly desirable. In this study, biaryl compounds were synthesized efficiently an organic Brønsted acid catalyst in flow system. Bayesian optimization-assisted...
Dehydrohelicenes are some of the most attractive chiroptical materials with unique helical chirality. However, to our knowledge, there no prior reports on their direct construction by asymmetric methods. In this work, sequential synthesis aza-oxa-dehydro[7]helicenes via electrochemical oxidative hetero-coupling 3-hydoxycarbazoles and 2-naphthols followed dehydrative cyclization intramolecular C-C bond formation has been realized. addition, an efficient enantioselective through chiral...
Abstract The electrochemical synthesis of hetero[7]helicenes including pyrrole and furan rings has been established. A single operation led to an oxidative heterocoupling dehydrative cyclization sequence afford oxaza[7]helicenes in 50–86% yields with 45–77% Faradic efficiencies. Their derivatization chiroptical properties were also investigated. magnified image
Leaf morphogenesis is essential for plant growth and development, yet the mechanisms by which viruses induce changes in leaf shape are not well understood. Rice ragged stunt virus (RRSV) infection induces distinct morphological abnormalities rice leaves, including tip curling serrated margins, through unknown pathogenic mechanisms. This study reveals that key regulatory microRNAs (miR164, miR319 miR156) their target genes (CUC, TCP SPL) exhibit entirely opposite expression patterns healthy...
The reaction of acetals with trialkylsilyl chloride (R3SiCl) leads to the deprotection acetal group, resulting in corresponding carbonyl compounds. Notably, aromatic dialkyl yield parent aldehydes and ketones good yields. conditions are very mild, allowing many acid-labile functional groups survive without any problems. Additionally, we clarified mechanism through an NMR study.
Abstract The adjustment of the main helical scaffold in helicenes is a fundamental strategy for modulating their optical features, thereby enhancing potential diverse applications. This work explores influence elongation (n = 5–9) on structural, photophysical, and chiroptical features symmetric oxa[ n ]helicenes. Crystal structure analyses revealed structural variations with extension, impacting torsion angles, pitch, packing arrangements. Through theoretical investigations using density...
The pursuit of chiral nanographenes with robust stability and good chiroptical responses is great interest for material-based applications.However, the most reported preparation processes involve intricate synthetic pathways harsh conditions, resulting in readily epimerization due to their low barriers.In this study, we present a streamlined one-pot electrochemical synthesis novel double oxaza[7]dehydrohelicene, characterized by substantial barrier (33.8 kcal mol -1 ) notable (|glum| = 1.5 ×...
A novel double aza-oxa[7]helicene was synthesized from the commercially available N1,N4-di(naphthalen-2-yl)benzene-1,4-diamine and p-benzoquinone in two steps. Combining acid-mediated annulation with electrochemical sequential reaction (oxidative coupling dehydrative cyclization) afforded this hetero[7]helicene. Moreover, structural optical features of molecule have been studied using X-ray crystallographic analysis, absorption emission behaviors were rationalized based on DFT calculations.
This research aimed to improve water solubility and oral bioavailability of a newly synthesized thienopyrimidine derivative (TPD) with anti-pancreatic cancer activity by loading on starch nanoparticles (SNPs).TPD was synthesized, purified its ADME behavior predicted using Swiss software. A UV spectroscopy method developed validated measure TPD concentration at various dosage forms. SNPs loaded (SNPs-TPD) were prepared, characterized for particle size, polydispersity index, zeta potential,...
Abstract Enantioselective oxidative couplings of 4-hydroxycarbazoles using a chiral dinuclear vanadium(V) complex have been achieved for the first time. Under mild reaction conditions, corresponding dimeric were obtained in up to 90% ee.
Autoxidation of aldehydes to peracids and carboxylic acids holds a significant impact in both academia industry due their wide applications organic synthesis environmental remediation.
Sulfonyl fluorides are highly versatile organic compounds with diverse applications in click chemistry, biochemistry, and materials science. However, traditional synthetic approaches such as halogen exchange of sulfonyl chlorides using potassium bifluoride (KHF2) face challenges for large-scale production due to KHF2's corrosiveness reactivity glassware. Moreover, the instability limited availability substrates further complicate their synthesis. In this study, we introduce two efficient...
Hydroxyethyl esters of diclofenac and mefenamic acid were prepared with the aim obtaining enzymatically labile prodrugs, their stability was evaluated in aqueous buffer solutions pH 7.4, 1 N HCl, also human plasma. The hydrolytic degradation ester slow, as shown by t1/2 values greater than 22 hr, while rapid enzymatic hydrolysis occurred plasma (t1/2 = 1.12 hr). However, showed a relatively higher 38 hr at 10) well 7.28 hr) compared ester. Therefore, would not be considered suitable prodrug.
C(aryl)–P bond cleavage via addition of phosphine to alkynyl ester in the presence water.
Anionic salicylimine-based cobalt (III) complexes featuring chiral ligands derived from isoleucine amino acids were used as efficient bifunctional phase-transfer catalysts for electrophilic iodination of enol ethers. The Brønsted these enabled the enantioselective asymmetric iodocyclization ethers, furnishing spiro-fused oxazoline derivatives in high yields with up to 90:10 er. In addition, catalyze intermolecular iodoacetalization ethers various alcohols afford 3-iodoacetal 92:8
This study presents the design of a phase-shifted DC-DC series-parallel full bridge resonant converter (PSFB-LLC) for battery charger application. The proposed is controlled by phase-shift pulse width modulation that switches inverter connected with tank; it equipped an isolated transformer (high frequency) and backed energy transfer achieving zero current switching (ZCS) at all primary active switches. magnetizing inductance was implemented in parallel angle to improve capacitance tank...