A5022231957- Carcinogens and Genotoxicity Assessment
- Bladder and Urothelial Cancer Treatments
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Reproductive Biology and Fertility
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Sperm and Testicular Function
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- Peroxisome Proliferator-Activated Receptors
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Sulfur Compounds in Biology
- Polyamine Metabolism and Applications
- Prostate Cancer Diagnosis and Treatment
- Ovarian function and disorders
- Gastric Cancer Management and Outcomes
- Connexins and lens biology
Tokushima University
2019-2023
Oita Medical Center
2023
Institute of Biomedical Science
2020
Tokushima Municipal Hospital
2017-2018
Tokushima University Hospital
2018
Ehime Prefectural Central Hospital
2014-2017
Sumitomo Chemical (United Kingdom)
2015
Sumitomo Chemical (Japan)
1997-2014
Kyushu University
1995-2009
Osaka City University
1996-2005
To investigate whether female fertility decreases with age due to poor oocyte quality, we examined the presence of DNA fragmentation in ovulated oocytes from young, mature and aged mice. Oocytes three groups mice (7–8, 20–24 40–48 weeks) were retrieved ovlducts 15 h after human chorionic gonadotrophin (HCG) injection.. each mouse incubated a CO2 Incubator for 0–60 tubal fluid (HTF). After incubation, was stained terminal deoxynucleotidyl transferase-mediated dUDP nick-end labelling (TUNEL)...
The modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione (TTAD) were investigated in a rat wide-spectnim organ carcinogenesis model. Animals initiated with two i.p. injections 1000 mg/kg body wt 2,2′-dihydroxy-di-n-propylnitrosamine (DHPN) followed by i.g. administrations 1500 N-ethyl-N-hydroxyethylnitrosamine (EHEN), then three s.c. 75 3,2′-dimethyl-4-amlnobiphenyl (DMAB) during first 3 weeks. Starting 1 week after...
Abstract To obtain information on the effects of nongenotoxic carcinogens at low doses for human cancer risk assessment, carcinogenic potential organochlorine insecticide, 1,1‐bis( p ‐chlorophenyl)‐2,2,2‐trichloroethane (DDT), in liver was assessed F344 rats. In experiment 1, 240 male animals, 21 days old, were administered 0, 0.5, 1.0, 2.0, 5.0, 20, 100 and 500 ppm DDT diet 16 weeks. Experiment 2 conducted to elucidate lower levels using 180 rats given 0.005, 0.01, 0.1, 0.2 0.5 ppm. The...
The expression of connexin 32 (Cx32), a major liver gap junction protein, after partial hepatectomy (PH) and during development progression hepatocarcinogenesis was studied in the rat. Cx32 quantitatively analyzed by counting immunohistochemically demonstrated protein spots on membranes hepatocytes. Livers were sequentially examined PH to assess correlation with cell proliferation. For analysis different stages carcinogenesis, assayed N-ethyl-N-hydroxyethylnitrosamine-induced enzyme altered...
Peroxisome proliferators are non-mutagenic carcinogens in the liver of rodents, acting both as initiators and promoters. The National Toxicology Program (NTP) conducted a study several peroxisome (PPs), including Wyeth (WY)-14643 prototypical PP 2,4-dichlorophenoxyacetic acid (2,4-D) weak PP, Sprague-Dawley rats, B6C3F1 mice, Syrian hamsters. In kidney, an unusual change was observed outer stripe medulla, especially rats treated with 2,4-D or WY-14643. This characterized by foci tubules that...
Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area stimulates catecholamine secretion from adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia neoplasia. We investigated possible correlation between nonneoplastic pulmonary lesions pheochromocytoma 9 recent, NTP, 2-year particulate inhalation studies male F344 rats. Re-evaluation for active inflammation, interstitial fibrosis, alveolar...
Stringent requirements are in place for the evaluation and registration of new compounds with biocidal or pesticidal activities. However, established from suppliers produced by a different manufacturing process have been less clear ambiguity exists as to how 'equivalence health hazards' can unequivocally be demonstrated analytically toxicological assays. The case presented this analysis focuses on chiral pyrethroid transfluthrin (TFL) synthesized esterification an acid chloride alcoholic...
Development of preneoplastic lesions in the rat liver under influence various modifiers was investigated with particular attention to changes simultaneous expression altered enzyme phenotype within (conformity) and proliferation potential. Degree conformity marker enzymes such as glutathione S‐transferase placental form (GST‐P), glucose‐6‐phosphate dehydrogenase (G6PD), glucose‐6‐phosphatase, adenosine triphosphatase γ‐glutamyltranspeptidase compared levels S‐bromo‐2‐deoxyuridine labeling....
To assess the possibility of establishing an in vivo, medium-term bioassay system for gastric carcinogens and promoters, a total 220 male WKY rats were divided into two groups. Group 1 animals treated first with single dose N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) (160 mg/kg body wt) starting 2 weeks later administrated one five carcinogens, promoter, non-gastric or no treatment, as control, 14 weeks. Saturated sodium chloride solution (1 ml) treatments given by intubation at 4, 6, 8 10....
Background/Aim: The aim of this study was to elucidate the relationship between progression bladder cancer (BCa) and TLR4 expression. Materials Methods: expression prognosis BCa patients analyzed using a publicly available database immunohistochemical staining clinical samples. effect knockdown also examined on invasive capabilities cells. Finally, investigate biological function TLR4, gene profile TLR4-depleted cells by microarray analysis. Results: Expression inversely associated with BCa,...
Preneoplastic and neoplastic liver cell lesions, induced by EHEN (N‐ethyl‐N‐hydroxyethylnitrosamine) in rats, were investigated to establish the numbers of simultaneously expressed altered enzyme phenotypes within lesion cells. The lesions divided into 5 classes on basis expression one or more following enzymes: glutathione S‐transferase placental form, glucose‐6‐phosphate dehydrogenase, glucose‐6‐phosphatase, adenosine triphosphatase, γ‐glutamyl transpeptidase. Class 1 contained cells...
In an approach to early detection of gastric carcinogens and promoters in vivo test system, promotion by sodium chloride (NaCl) the synergistic effects NaCl taurocholate (Na‐TC) on development pepsinogen‐altered pyloric glands (PAPG) rat glandular stomach after initiation with N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) were investigated. A total 205 male WKY/NCrj rats divided into 8 groups. Group 1 was given a single dose MNNG 160 mg/ kg body weight intubation, starting 2 weeks later basal...
A new appraach to low-dose assessment of carcinogenic potential was applied food contaminant pyrolysis products. Single intragastric doses the pyrolysates, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), were given 12 h after two-thirds partial hepatectomy (PH) F344 male rats. Two week thereafter animals placed on a basal diet containing 0.05% phenobarbital (PB) for 6 weeks combined with an i.p. administration D-galactosamine (30 mg/kg...
The influence of the console surgeon on feasibility and outcome various robot-assisted surgeries has been evaluated. These variables may be partially affected by skills patient-side (PSS), but this not evaluated using objective data. This study aimed to describe surgical techniques PSS in radical cystectomy (RARC) intracorporeal ileal conduit (ICIC) urinary diversion objectively examine changes outcomes with increasing experience. During a 3-year period, 28 men underwent RARC ICIC diversion....
Abstract Background Post-transplant de novo thrombotic microangiopathy (TMA) is a rare yet serious complication that generally can develop in renal transplant recipients immediately after reperfusion or several months transplantation. Here, we report case of systemic tacrolimus-associated TMA patient diagnosed 2 years Case presentation A 49-year-old woman presented with severe anemia 18 undergoing Anemia was refractory to recombinant human erythropoietin and suspected be due excessive...
In the present study, susceptibility of CB6F1 mice carrying human prototype c-Ha- ras gene (rasH2 mice) and p53 knockout ( (+/−) to urethane-induced lung carcinogenesis was compared under same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for 3 weeks. At week 26, adenocarcinomas adenomas observed 53% 100% rasH2 mice, respectively, 67% littermate (non-Tg) mice. However, tumors not either or (+/+) Peliosis hepatis hepatic hemangiomas 27% but...
This study aimed to analyze the impact of patients' nutritional status and changes in body composition on prognosis metastatic renal cell carcinoma (mRCC) patients who received systemic therapy with tyrosine kinase inhibitors (TKIs).A total 57 mRCC TKIs as first-line at our facility between November 2004 October 2018 were included. The Prognostic Nutritional Index (PNI) was used evaluate their status. volumes skeletal muscle mass fat tissue calculated using SYNAPSE VINCENT system. effects...
Surface modification of a polycrystalline tungsten (W) mirror due to low-energy helium plasma irradiation has been studied in the compact plasma–wall interaction (PWI) simulator APSEDAS. Many fine irregularities few μm are generated on W surface at Ts~1400 K He bubble formation. On other hand, distinctive change morphology cannot be seen from SEM micrograph exposed Ts<710 K. In both samples, optical reflectivity with incident angle θ=5° decreases more shorter wavelength. From situ...