A5101784527- Biomedical Text Mining and Ontologies
- Multiple Myeloma Research and Treatments
- Ethics in Clinical Research
- Gene expression and cancer classification
- Cancer Treatment and Pharmacology
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Semantic Web and Ontologies
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Growth Hormone and Insulin-like Growth Factors
- Cystic Fibrosis Research Advances
- Nuclear Structure and Function
- Research Data Management Practices
- Cytokine Signaling Pathways and Interactions
- Viral-associated cancers and disorders
- Dermatological and Skeletal Disorders
- Scientific Computing and Data Management
- Single-cell and spatial transcriptomics
- Dendrimers and Hyperbranched Polymers
- FOXO transcription factor regulation
- Infections and bacterial resistance
- Genomics and Phylogenetic Studies
- Persona Design and Applications
Karolinska University Hospital
2024
Karolinska Institutet
2013-2024
Hospital Universitario 12 De Octubre
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Hospital Clínico San Carlos
1989-2019
Lund University
2013
Novo Nordisk Foundation
2013
Skåne University Hospital
2013
University of Copenhagen
2013
The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that are not fully understood. We identified the repressor element (RE)-1 silencing transcription factor (REST) as mediator AR on gene repression. Chromatin immunoprecipitation showed binds chromatin regions containing well-characterized cis-elements known to mediate REST transcriptional repression, while cell imaging studies confirmed and closely co-localize in vivo. Androgen-induced repression also...
Abstract HPV vaccination with concomitant HPV-based screening of young women has been proposed for faster cervical cancer elimination. We describe the baseline results a population-based trial this strategy to reduce incidence HPV. All 89,547 born 1994-1999 and resident in capital region Sweden were personally invited 26,125 (29.2%) enrolled between 2021-05-03 2022-12-31. Baseline genotyping samples from study participants finds, compared pre-vaccination prevalences, strong decline HPV16 18...
Numerous successful scientific results have emerged from projects using shared biobanked samples and data. In order to facilitate the discovery of underutilized biobank samples, it would be helpful if a global register containing descriptive information about existed. But first, for data comparable, needs harmonized. compliance with aim BBMRI (Biobanking Biomolecular Resources Research Infrastructure), harmonize biobanking across Europe, conclusion that move towards universal infrastructure...
Biobanks are the biological back end of data-driven medicine, but lack standards and generic solutions for interoperability information harmonization. The move toward a global infrastructure biobanking demands semantic through harmonized services common ontologies. To tackle this issue, Minimum Information About BIobank data Sharing (MIABIS) was developed in 2012 by Biobanking BioMolecular Resources Research Infrastructure Sweden (BBMRI.se). wide acceptance first version MIABIS encouraged...
The question of a potential biological sexual signature in the human brain is heavily disputed subject. In order to provide further insight into this issue, we used an evolutionary approach identify genes with sex differences expression level among primates. We reasoned that patterns important uphold key male and female characteristics may be conserved during evolution. selected cortex for our studies because specific region responsible many higher behavioral functions. compared gene...
BackgroundAlcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors Nuclear Factor-kappaB (NF-κB) family, controlling neuronal plasticity neurodegeneration, are involved these adaptations human alcoholics.Methods FindingsAnalysis DNA-binding NF-κB (p65/p50 heterodimer) the p50 homodimer as well proteins mRNAs was performed...
support for the investigation of contribution altered ribosomal biogenesis to an oncogenic differentiation block.
The GH-activated signal transducer and activator of transcription 5b (STAT5b) is an essential regulator somatic growth. transcriptional response to STAT5b in liver poorly understood. We have combined microarray-based expression profiling phylogenetic analysis gene regulatory regions study the interplay between GH regulation hepatic expression. acute vivo after a single pulse was studied hypophysectomized rats presence either constitutively active or dominant-negative delivered by adenoviral...
Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step improve patient treatments and create the most adequate tools for personalized medicine. However, growing number of disease-specific brings also new technical challenges. Usually, systems developed as closed silos, with independent formats models, lacking comprehensive mechanisms enable sharing. To tackle challenges, we Semantic Web based solution that...
The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology facilitate sharing biobanks and sample collections. Core consists of three components describing biobanks, collections, studies, which information on samples donors is provided at aggregated form. However, there also need describe an individual level allow more elaborate queries available data. Therefore the has now been extended with level.
Biobanks are a critical resource for translational science. Recently, semantic web technologies such as ontologies have been found useful in retrieving research data from biobanks. However, recent has also shown that there is lack of about the administrative aspects These would be helpful to answer research-relevant questions what scope specimens collected biobank, curation status specimens, and contact information curators Our use cases include giving researchers ability retrieve key (e.g....
Abstract GH plays a central role in controlling somatic growth, tissue regeneration, and intermediary metabolism most vertebrate species through mechanisms dependent on the regulation of gene expression. Recent studies using transcript profiling have identified large cohorts genes whose expression is induced by GH. Other results demonstrated that signal transducer activator transcription (Stat) 5b, latent factor activated receptor-associated protein kinase, Jak2, key agent GH-stimulated...
Biobanks are an organized collection of biological material and associated data. They a fundamental resource for life science research contribute to the development pharmaceutical drugs, diagnostic markers deeper understanding genetics that regulate all on earth. well established in High Income Countries (HIC) rapidly emerging Low Middle (LMIC). Surveys among biobanks operating LMIC setting indicate limited resources short term funding tied specific projects threaten sustainability biobanks....
A laboratory information management system (LIMS) is central to the informatics infrastructure that underlies biobanking activities. To date, a wide range of commercial and open-source LIMSs are available decision opt for one LIMS over another often influenced by needs biobank clients researchers, as well financial resources. The Baobab was developed customizing Bika software ( www.bikalims.org ) meet requirements best practices. need implement standard operation procedures stimulate use...
Background: The blood units, stored as packed red cells (PRBC), are supplied according to the first-in-first-out (FIFO) criterion. However, actual quality of PRBC provided for transfusion, namely their capacity exert expected transfusion outcome, is not addressed. Aims: present study was undertaken analyze unit-to-unit variability in deformability during cold-storage. Methods: Study design: RBC samples were obtained from 20 leukoreduced SAGM under standard conditions, and monitored day...
Abstract The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden from organised screening program non-organised testing samples. cohort started in 2011 has enrolled more than 670,000 women, contributing with 1.2 million biobanked is systematically updated individual-level data Swedish National Registry (NKCx). Key variables include birthdate, sampling date, cytological, histopathological HPV analysis...
The Human Exposome Assessment Platform (HEAP) is a research resource for the integrated and efficient management analysis of human exposome data. project will provide complete workflow obtaining actionable knowledge from population-based cohorts. HEAP state-of-the-science service composed computational resources partner institutions, accessed through software framework that provides world’s fastest Hadoop platform data warehousing applied artificial intelligence (AI). software, decision...
Data quality has recently become a critical topic for the research community. European guidelines recommend that scientific data should be made FAIR: findable, accessible, interoperable and reusable. However, as FAIR do not specify how stated principles implemented, it might straightforward researchers to know actually make their FAIR. This can prevent life-science from sharing datasets pipelines, ultimately hindering progress of research. To address this difficulty, we developed BIBBOX,...
Summary Neoplasms of the lymphoid tissues represent a large, heterogeneous group diseases that vary in clinical severity and response to treatment. The incidence lymphoma older patients is growing, yet guidelines on specifically how these should be treated are lacking. Moreover, people excluded from most trials management decisions usually based data obtained younger patients. This review might consider optimal strategy for diagnosis treatment