A5064341902- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Cancer Cells and Metastasis
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Virus-based gene therapy research
- Genetic and Kidney Cyst Diseases
- Urinary Tract Infections Management
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Minimally Invasive Surgical Techniques
- Hormonal and reproductive studies
- Genital Health and Disease
- Chronic Lymphocytic Leukemia Research
Kyorin University
2014-2023
Kyorin University Hospital
2011-2020
The University of Texas Southwestern Medical Center
2000-2005
Children's Hospital of Philadelphia
2001
The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment infection, but its physiologic functions have not been described. In nonpolarized cells, CAR localized to homotypic intercellular contacts, mediated cell aggregation, recruited the tight junction protein ZO-1 sites of cell–cell contact. polarized epithelial colocalized junctions could be coprecipitated from lysates. expression led reduced passage macromolecules ions across monolayers, soluble inhibited formation...
Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated However, intratumor metabolic not investigated. Here, we used global metabolomics analysis tissue slice tracer studies to demonstrate that different portions human primary tumor possess characteristics drug sensitivity. Pyruvate levels were elevated pyruvate metabolism was...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Apr 2002Cell Adhesion Proteins As Tumor Suppressors Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, and Jer-Tsong Hsieh OkegawaTakatsugu Okegawa , LiYingming Li PongRey-Chen Pong HsiehJer-Tsong View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65245-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We summarize recent progress on the...
Acute pyelonephritis (APN) with obstructive uropathy is not uncommon and often causes serious conditions including sepsis septic shock. We assessed the risk factors for shock in patients APN associated upper urinary tract calculi. retrospectively studied 69 calculi who were admitted to our hospital. Emergency drainage decompression of renal collecting system was performed empirical treatment cases failure initial severe cases. by multivariate logistic regression analysis. Overall, 45 (65.2...
Objective We examined whether androgen receptor splice variant 7 (AR‐V7) in circulating tumor cell(CTC)clusters can be used to predict survival patients with bone metastatic castration resistant‐prostate cancer (mCRPC) treated abiraterone or enzalutamide. Methods retrospectively enrolled 98 CRPC on enzalutamide, and investigated the prognostic value of CTC cluster detection (+ v −) AR‐V7 using a − based mRNA assay. ≤50% prostate‐specific antigen (PSA) responses, PSA progression‐free...
Using the CellSearch System we evaluated whether circulating tumor cells predict survival in patients with hormone refractory prostate cancer.Circulating were counted whole blood. This system was developed using epithelial cell adhesion cancer antibody based, immunomagnetic capture and automated staining methodology. Blood samples from 64 analyzed.A threshold of 5 or more per 7.5 ml blood used to evaluate ability survival. Patient charts retrospectively examined determine median overall...
No AccessJournal of UrologyAdult Urology1 Oct 2008Immunomagnetic Quantification Circulating Tumor Cells as a Prognostic Factor Androgen Deprivation Responsiveness in Patients With Hormone Naive Metastatic Prostate Canceris accompanied byWAVE1 is Associated Invasiveness and Growth Cancer Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara OkegawaTakatsugu Okegawa , NutaharaKikuo Nutahara HigashiharaEiji View All Author Informationhttps://doi.org/10.1016/j.juro.2008.06.021AboutFull TextPDF...
<b><i>Background:</i></b> Kidney volume (KV) becomes clinically relevant in autosomal dominant polycystic kidney disease (ADPKD) management. KV can be conveniently estimated (ceKV) using ellipsoid equations with three axes measurements; however, the accuracy and reliability are unknown. <b><i>Methods:</i></b> KVs of 347 kidneys 177 consecutive ADPKD patients were determined a volumetric method (standard-KV), ceKV was calculated six different...
The Vesical Imaging Reporting and Data System (VI-RADS) was launched in 2018 to standardize reporting of magnetic resonance imaging for bladder cancer. This study aimed prospectively validate VI-RADS using a next-generation scanner investigate the usefulness denoising deep learning reconstruction.We enrolled 98 patients who underwent multiparametric before transurethral resection tumor. Tumors were categorized according VI-RADS, we ultimately analyzed 68 with pathologically confirmed...
To assess whether circulating tumor cells with tumor-related methylated DNA can be used to predict survival in patients hormone-refractory prostate cancer.Blood samples from 76 cancer were analyzed. Circulating enumerated the CellSearch System whole blood. This system was developed using an epithelial cell adhesion molecule antibody-based immunomagnetic capture and automated staining methodology. Hypermethylation at adenomatosis polyposis coli, glutathione-S-transferase-pi,...
Nuclear receptors (NRs) are a class of transcription factors that closely involved in the progression certain types cancer. We aimed to study relation between bladder cancer and NRs, with special focus on orphan NRs whose ligands functions have not been identified. First, we examined expression levels 22 genes encoding clinical found hepatocyte nuclear factor 4γ (HNF4G; NR2A2) NR2F6 were upregulated most frequently tissues compared their paired normal tissues. Knockdown overexpression each...
To develop a modified Vesical Imaging Reporting and Data System (VI-RADS) without dynamic contrast-enhanced imaging (DCEI), termed "non-contrast-enhanced VI-RADS (NCE-VI-RADS)", to assess the additive impact of denoising deep learning reconstruction (dDLR) on NCE-VI-RADS.From January 2019 through December 2020, 163 participants who underwent high-gradient 3-T MRI bladder were prospectively enrolled. In total, 108 with pathologically confirmed cancer by transurethral resection analyzed....
Background: The aim of this study was to investigate the outcome laparoscopic excision urachal remnants (LUR), and compare with that traditional open (OUR). Methods: Between February 2001 December 2005, six patients a mean age 23.8 years who had symptomatic sinus underwent radical LUR. Using 12 mm 5 ports, caudal stump urachus ligated an absorbable clip divided. peritoneal preperitoneal tissue between medial umbilical ligaments dissected free transversalis fascia. Dissection carried out...
To evaluate the relationship between circulating tumor cells (CTC) and clinical parameters in metastatic urothelial cancer (UC).CTC were enumerated with CellSearch System, which was developed using an EpCAM antibody-based immunomagnetic capture automated staining methodology. UC cell lines (RT4, T24, TCC, UMUC3 253J) mixed blood from healthy males analyzed. Blood samples 16 patients without 20 also analyzed.The accuracy reliability of assay determined spiked (RT4 T24), showed a strong linear...
Abstract Aim This study aimed to evaluate sexual activity and quality of life (QOL) after transvaginal mesh (TVM) surgery in Japanese patients with pelvic organ prolapse (POP). The objective cure rate associated complications were also investigated. Methods cases who underwent TVM retrospectively analyzed. QOL was assessed using the Prolapse Quality Life Questionnaire (P‐QOL), function evaluated Female Sexual Function Index (FSFI) before 12 months surgery. Results A total 237 completed...
Some risk classifications to determine prognosis of patients with non-muscle invasive bladder cancer (NMIBC) have disadvantages in the clinical setting. We investigated whether EORTC (European Organization for Research and Treatment Cancer) stratification is useful predict recurrence progression Japanese NMIBC. In addition, we developed validated a novel, simple classification recurrence.
Abstract Background Acute pyelonephritis (APN) with obstructive uropathy often causes sepsis. Recently, sepsis was redefined using the sequential organ failure assessment (SOFA) score, based on new Sepsis-3 criteria. We investigated predictors for this definition in patients APN associated upper urinary tract calculi. Methods retrospectively evaluated who were admitted to our hospital treatment of Blood and urine samples collected before APN. Treatment included adequate antimicrobial therapy...
Abstract Purpose: Although cell-free DNA (cfDNA) testing is expected to drive cancer precision medicine, little known about the significance of detecting low-frequency variants in circulating tumor (ctDNA) castration-resistant prostate (CRPC). We aimed identify genomic profile including ctDNA from patients with CRPC and investigate clinical utility variant allele frequency (VAF) below 1%. Experimental Design: This prospective, multicenter cohort study enrolled eligible for treatment...