Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies the intake can adversely influence reproductive performance. The present study aimed evaluate effects of curcumin nano-emulsion on deficient diet (PDD)-induced testicular atrophy, troubled spermatogenesis decreased performance male rats.Juvenile rats were fed (PDD) for 75 days. Starting day 60 divided into 4 groups given corresponding...

The aim of the current manuscript was to test applicability a nanocomposite system penetration enhancer vesicles (PEVs) within polymeric in situ forming gel network composed poloxamer and hyaluronic acid for intranasal delivery antiemetic dimenhydrinate (DMH). PEVs were prepared using phospholipids labrasol/transcutol/PEG 400 as enhancers, characterized entrapment efficiency (EE%), particle size, zeta potential morphology. its sol-gel temperature, viscosity mucoadhesiveness,...

The relationship between the incidence of cardiovascular abnormalities and non-alcoholic fatty liver disease (NAFLD) has long been postulated. Curcumin (CUR) is a potential anti-atherosclerotic agent but its poor water solubility hinders pharmacological use. Therefore, present study aimed to investigate effect formulation CUR nanoemulsion prepared using spontaneous emulsification technique on high fat fructose (HFHF)-induced hepatic cardiac complications. Fifty Wistar rats were divided into...

Abstract Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence side effects. However, efficacy is limited by some challenges, namely poor solubility, permeability, and, consequently, bioavailability. Delivery carriers proven that they can overcome almost all aforementioned limitations, leading improvement pharmacological nutraceuticals. Among promising nutraceuticals currently evoked...

Abstract Malnutrition and low dietary protein intake could be risk factors for developing peripheral central hyperammonemia, especially in pediatrics. Both curcumin resveratrol proved to effective against several hepatic cerebral injuries. They were reported beneficial lowering circulating ammonia levels, yet both are known their bioavailability. The use of pharmaceutical nano-formulations as delivery systems these two nutraceuticals solve the aforementioned problem. Hence, present study...

Formulation of Diclofenac Sodium tablets using Tapioca starch powder- A promising binderYamini.K, Chalapathi. V, N. Lakshmi Narasimha Reddy, K.V. Lokesh, S. Praveen Kumar Gopal.V.

The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks induce steatohepatitis. CoQ10 (10 mg/(kg·day)-1) was orally administered 2 consecutive weeks. Twenty-four hours after last dose drug, behavioral test, namely cage performed counts recorded. Serum alanine transaminase, aspartate...

Prophylactic therapy use to cure patients suffer from depression: a holistic approach for health benefitPankaj Nainwal, Deepak Nanda, Karan Dhamija

Acute paracetamol over dose-induced hepatotoxicity is considered an important medical hazard especially among women. Omega-3 long-chain polyunsaturated fatty acids (Omega-3 PUFAs) daily doses are nowadays recommended for their antioxidant and anti-inflammatory potentials. Fourier transform infrared (FTIR) spectroscopy a reliable method in analyzing cellular alterations now efficiently used to diagnose several diseases the efficacy of drugs even early stages. The aim our study was evaluate...

High consumption of industrialized food with high fat content is generally associated insulin resistance, which in turn causes memory impairment and cognitive decline. Nicotinamide ascorbic acid are among the promising neuroprotective molecules; however, an appreciable therapeutic activity necessitates administration a large dose either. Therefore, study aimed to assess if loading them chitosan nanoparticles doses 5–10 times lower than unencapsulated forms would achieve comparable results....

Abstract Objectives Curcumin is a promising nutraceutical with reported diverse therapeutic properties, but of limited oral bioavailability. The current manuscript investigates the role encapsulation curcumin in nanoemulsion form counteracting adverse effect chronic ingestion high-fat high-fructose diet (HFHF) by juvenile male rats regarding testicular abnormalities and declined spermatogenesis. Methods was administered orally to Wistar at dose 5 or 10 mg/kg compared powder, followed...

The effectiveness of cisplatin in cancer treatment renders its use vital to clinicians. However, the accompanying side effects as cachexia, emesis and liver damage necessitate a dietary supplement which is capable hindering such undesirable complications. branched chain amino acids well glutamine arginine have been proven be effective nutritional co-adjuvant therapeutic agents. Furthermore, new pharmaceutical approaches encompass designing organ-targeted nanoformulations increase medicinal...

The production of biopolymers from waste resources is a growing trend, especially in high-population countries like Egypt. Beta-glucan (β-glucan) belongs to natural polysaccharides that are derived plant and microbial origins. In this study, following increasing demands for β-glucan owing its bioactive properties, statistical model enhance was evaluated usefulness the food pharmaceutical industries. addition, trial convert polymer nanostructure form done increase bioactivity.Ingredients...

There are numerous herbal medicines that have been introduced into psychiatric practice because of greater compliance and milder side effects. Polygonum cuspidatum is a native Asian plant; known for its medicinal properties traditionally used in the treatment neuropsychiatric disorders, such as psychosocial stress, dementia Parkinson's disease. Resveratrol active ingredient P. cuspidatum. Researchers suggested trans-isomer resveratrol demonstrates variety pharmacological activities including...

<h2>Abstract</h2> Fibrosis represents a common outcome of almost all chronic liver diseases and leads to an impairment function that requires medical intervention. The current study aimed evaluate the potential anti-fibrotic effect <i>Saccharomyces cervisciae</i> cell wall extract (SCCWE) against thioacetamide (TAA)-induced fibrosis in rats (200mg/kg b.w. i.p. twice weekly for 6 weeks) using Ursodeoxycholic acid (UDCA) as reference product. SCCWE at two doses (50 100 mg/kg) significantly...

Protective effect of curcumin on oxidative stress and DNA fragmentation against lambda cyhalothrin-induced liver damage in ratsNaglaa K. Madkour

Abstract Background Cisplatin is considered one of the most effective and commonly used chemotherapeutic drugs, but despite its high therapeutic effectiveness, patients treated with cisplatin suffer from nausea vomiting, neurotoxic side effects, cerebral psychiatric disorders such as depression. Therefore, aim current work was to explore whether a selective 5-HT 3 receptor antagonist (Ondansetron) administered via oral route or intranasally in microemulsion form would alleviate cisplatin’s...

Abstract Ethanolic and aqueous leaf extracts of Ficus cyathistipula significantly reduced blood-glucose level, improved triglycerides cholesterol levels dyslipidemia in diabetic-rats. They similarly the inflammation paw-edema stomach-ulcers rats. Fractions obtained by successive partition ethanolic extract were assessed for their cytotoxicity, antioxidant antimicrobial activities; Petroleum ether fraction was most cytotoxic (IC 50 = 4.43 ± 0.2, 17.3 2.22 15.5 3.67 μg/ml on MCF7, HepG2 HeLa...

The development of obesity and prediabetes under conditions long-term consumption fructose solution in ratsVictoria Konopelnyuk, Alona Yurchenko, Taras Karpovets, Ludmila Ostapchenko

Neuroprotective role of Melatonin against aluminum-induced oxidative stress in the hippocampus mouse brainN. John Sushma, S. Priyanka, K. Jayantha Rao