A5038149487- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Global Maternal and Child Health
- Reproductive Health and Contraception
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Impact on Reproduction
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Pregnancy and Medication Impact
- Adolescent Sexual and Reproductive Health
- Homelessness and Social Issues
- Memory and Neural Mechanisms
- Genetic Associations and Epidemiology
- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Opioid Use Disorder Treatment
- Trace Elements in Health
- Poverty, Education, and Child Welfare
- Bioinformatics and Genomic Networks
- Pregnancy and preeclampsia studies
National Center for Injury Prevention and Control
2020-2025
Centers for Disease Control and Prevention
2014-2025
Brigham and Women's Hospital
2015-2024
Harvard University
2010-2023
Cohort (United Kingdom)
2023
National Center on Birth Defects and Developmental Disabilities
2014-2021
Massachusetts General Hospital
2010-2021
National Center for Chronic Disease Prevention and Health Promotion
2020
United States Public Health Service
2017
Puerto Rico Department of Health
2016
Impairment in instrumental activities of daily living (IADL) leads to early loss productivity and adds significant burden caregivers. Executive dysfunction is thought be an important contributor functional impairment. The objective this study was investigate the relationship between executive function IADL a large cohort well-characterized normal older controls, mild cognitive impairment (MCI), patients with Alzheimer's disease, separately as well across entire sample, while accounting for...
CDC has developed interim guidelines for health care providers in the United States who are caring infants born to mothers traveled or resided an area with Zika virus transmission during pregnancy. These include recommendations testing and management of these infants. Guidance is subject change as more information becomes available; latest information, including answers commonly asked questions, can be found online (http://www.cdc.gov/zika). Pediatric should work closely obstetric identify...
CDC has developed interim guidelines for health care providers in the United States who are caring infants born to mothers traveled or resided an area with Zika virus transmission during pregnancy. These include recommendations testing and management of these infants. Guidance is subject change as more information becomes available; latest information, including answers commonly asked questions, can be found online (http://www.cdc.gov/zika). Pediatric should work closely obstetric identify...
Prevention of unintended pregnancy is a primary strategy to reduce adverse and birth outcomes related Zika virus infection. The Contraception Access Network (Z-CAN) aimed build network health-care providers offering client-centred contraceptive counselling the full range reversible contraception at no cost women in Puerto Rico who chose prevent during 2016-17 outbreak. Here, we describe Z-CAN programme design, implementation activities, baseline characteristics first 21 124 participants.
From 2004 to 2014, the incidence of neonatal abstinence syndrome (NAS) in United States increased 433%, from 1.5 8.0 per 1,000 hospital births. The latest national data 2014 indicate that one baby was born with signs NAS every 15 minutes (1). is a drug withdrawal most commonly occurs among infants after utero exposure opioids, although other substances have also been associated NAS. Prenatal opioid has poor fetal growth, preterm birth, stillbirth, and possible specific birth defects (2-5)....
Background When making decisions about medication use in pregnancy, women consult many information sources, including the Internet. The aim of this study was to assess content publicly accessible YouTube videos that discuss pregnancy. Methods Using 2023 distinct combinations search terms related medications and we extracted metadata from using a video Application Programming Interface. Relevant were defined as those with term pregnancy-related either title or description. We viewed relevant...
Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes. Increasing evidence links infection during pregnancy to adverse and birth outcomes, including loss, intrauterine growth restriction, eye defects, congenital brain abnormalities, other fetal abnormalities. The has also been determined be sexually transmitted. Because of the potential risks associated with pregnancy, CDC recommended that health care providers discuss prevention unintended women couples who reside in...
Abstract We modeled the potential cost-effectiveness of increasing access to contraception in Puerto Rico during a Zika virus outbreak. The intervention is projected cost an additional $33.5 million family planning services and likely be cost-saving for healthcare system overall. It could reduce virus–related costs by $65.2 ($2.8 from less testing monitoring $62.3 avoided virus–associated microcephaly [ZAM]). estimates are influenced methods used, frequency ZAM, lifetime incremental ZAM....
Zika virus infection during pregnancy can cause congenital microcephaly and brain abnormalities (1,2). Since 2015, has been spreading through much of the World Health Organization's Region Americas, including U.S. territories. is spread bite Aedes aegypti or albopictus mosquitoes, by sex with an infected partner, from a pregnant woman to her fetus pregnancy.* CDC estimates that 41 states are in potential range mosquitoes (3), on July 29, 2016, Florida Department identified area one...
Alzheimer's disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain's functional connectivity. Assessing these alterations has become topic of increasing interest. However, few studies have examined different stages AD from complex network perspective cover topological scales. This study used resting state fMRI data to analyze trend connectivity cognitively normal (CN) through early and late mild impairment (EMCI LMCI) disease. The analyses had been...
Instrumental activities of daily living (IADL) impairment in Alzheimer's disease has been associated with global amyloid deposition postmortem studies. We sought to determine whether IADL is increased cortical Pittsburgh Compound B (PiB) retention.Fifty-five subjects (19 normal older controls, NC, and 36 mild cognitive impairment, MCI) underwent clinical assessments dynamic PiB positron emission tomography imaging.A linear multiple regression model showed that greater was retention all (R(2)...
At present, further investigations are needed in patients with suspected pulmonary tuberculosis (TB) and either negative sputum smear or without sputum. The aim of the present study was to analyse yield bronchoalveolar lavage fluid (BALF) PCR confirmed TB. Patients a positive culture for Mycobacterium complex BALF were analysed over 5 yrs. In total, 90 out 230 (39%) culture-positive TB had smear, 120 underwent bronchoscopy. 56 (47%), 93 (78%) patients, and/or 83%. 71 who bronchoscopy...
Our study sought to explore the actual and potential roles of patients, physicians, pharmacists, as well their shared challenges opportunities, in improving safety medication use during pregnancy. We conducted virtual focus groups with 48 women in-depth interviews nine physicians five pharmacists. Qualitative analysis revealed that all three participants reported “playing it safe,” need for an engaged patient making informed decisions, surrounding communication about pregnancy status, a lack...
Abstract There is well-documented evidence of brain network differences between individuals with Alzheimer’s disease (AD) and healthy controls (HC). To date, imaging studies investigating networks in these populations have typically been cross-sectional, the reproducibility such findings somewhat unclear. In a novel study, we use longitudinal ADNI data on whole to jointly compute at baseline one-year using state art approach that pools information across both time points yield distinct...
Recent public health emergencies have highlighted the unique vulnerabilities of pregnant women and infants to emerging threats critical role surveillance. Surveillance systems can collect data measure impact a disease or disaster be used inform clinical guidance prevention strategies. These also tailored on vulnerable populations, such as their infants. Novel surveillance assess risks outcomes been established during but typically cease collection once response has ended, limiting our...
Zika virus infection during pregnancy is a cause of microcephaly and other serious brain abnormalities (1). To support state territory response to the threat Zika, CDC's Interim Response Plan outlined activities for vector control; clinical management exposed pregnant women infants; targeted communication about transmission among men reproductive age; primary prevention Zika-related adverse birth outcomes by unintended pregnancies through increased access contraception.* The most highly...
During the 2016–2017 Zika virus outbreak, preventing unintended pregnancy was recognized as a primary strategy to reduce adverse Zika-related and birth outcomes. To increase awareness uptake of contraceptive services provided through Contraception Access Network (Z-CAN) in Puerto Rico, multi-strategy campaign called Ante La Duda, Pregunta (ALDP) developed. The principal aim Z-CAN services, which included same-day access full range reversible contraceptives at no cost women living Rico who...