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Zhihua Chen

ORCID: 0000-0002-9127-0510
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About
Contact & Profiles
A5087237154
Research Areas
  • Mycobacterium research and diagnosis
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Neutropenia and Cancer Infections
  • Antibiotic Resistance in Bacteria
  • Histone Deacetylase Inhibitors Research

Moffitt Cancer Center
 2024

 Histone Deacetylase Inhibitors Directly Modulate T Cell Gene Expression and Signaling and Promote Development of Effector-Exhausted T Cells in Murine Tumors
OPENALEX - Publications 
Mohammed L. Ibrahim Hong Zheng Margaret L. Barlow Yousuf Latif Zhihua Chen and 2 more Xiaoqing Yu Amer A. Beg

Epigenetic regulation plays a crucial role in the development and progression of cancer, including antitumor immunity. The reversible nature epigenetic modifications offers potential therapeutic avenues for cancer treatment. In particular, histone deacetylase (HDAC) inhibitors (HDACis) have been shown to promote T cell immunity by regulating myeloid types, enhancing tumor Ag presentation, increasing expression chemokines. HDACis are currently being evaluated determine whether they can...

10.4049/jimmunol.2300475 article EN The Journal of Immunology 2024-01-03
 [Bacterial distribution and drug resistance of pathogens of blood stream infection in children with hematological malignancies after chemotherapy].
OPENALEX - Publications 
Yi‐Rong Zheng Jingjing Li Shaohua Le Hui Zheng Xin Hua and 4 more Zhihua Chen Lin Zheng C Chen Jianda Hu

10.3760/cma.j.issn.0253-2727.2019.03.014 article EN PubMed 2019-03-14
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