A5086266710- Hormonal and reproductive studies
- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Reproductive Biology and Fertility
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Reproductive Health and Technologies
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Ovarian function and disorders
- Genital Health and Disease
- Sexuality, Behavior, and Technology
- Pharmacology and Obesity Treatment
- Selenium in Biological Systems
- COVID-19 Impact on Reproduction
- Fatty Acid Research and Health
- Reproductive System and Pregnancy
- Testicular diseases and treatments
- Eating Disorders and Behaviors
- Prostate Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Healthcare and Venom Research
- Prenatal Screening and Diagnostics
- Female Genital Mutilation/Cutting Issues
- Marriage and Sexual Relationships
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2015-2025
Sechenov University
2016-2024
Ministry of Health of the Russian Federation
2018-2024
Pirogov Russian National Research Medical University
2006-2020
National Medical and Surgical Center named after N.I. Pirogov
2015-2020
Moscow State University of Medicine and Dentistry
2017-2020
Endocrinology Research Center
2020
Saratov State Medical University
2018-2019
Peoples' Friendship University of Russia
2019
"National Medical Research Center for Rehabilitation and Balneology" of the Ministry of Health of the Russian Federation
2019
Infertility affects an estimated 15% of couples globally. Male factor infertility accounts for about a half cases. About 40% infertile men have varicocele. The aim this study was to investigate the efficacy and safety complex acetyl-L-carnitine, L-carnitine fumarate alpha-lipoic acid (SpermActin-forte) (SA) adjuvant antioxidant therapy after microsurgical varicocelectomy (MVE) in with varicocele assess its impact on level DNA fragmentation sperm cells.This is open, prospective, randomized...
Oxidative stress of sperm is a common pathologic condition, which can be detected in 30-80% infertile men. It established that dietary consumption antioxidants and microelements contributes to an increase conception probability subfertile couples, also reduces the risk reproductive losses. Drug complexes influencing various factors spermatogenesis disturbance (oligo-, astheno-, teratozoospermia), oxidative level DNA fragmentation are greatest reasonable interest.To study effects complex...
The aim of this work is to assess the possibility metabolomic (specifically lipidomic) analysis seminal plasma identify patients with preserved focal spermatogenesis in testes who may have a reasonable chance sperm retrieval during microTESE procedure.lipid composition semen samples from 64 men azoospermia and 24 fertile control was analyzed. Lipids were isolated by modified Folch extraction method. Lipid extracts analyzed reverse phase liquid chromatography coupled mass spectrometry....
Varicocele-related infertility is traditionally considered an indication for surgery. At the same time in some specific clinical settings, especially with subclinical varicocele, conservative therapy using hormonal or antioxidant drugs also possible. The potential role of drug this patient category remains controversial. article discusses options and treatment regimens men varicocele-related infertility. Given difficulties interpreting results studies heterogeneity data, it not yet possible...
Background: Although it is well known that the metabolic syndrome a common cause of erectile dysfunction (ED) pathogenesis latter in this group patients poorly understood. The present study aimed to improve our knowledge area. Methods: included 385 men with ED (control group) who underwent full evaluation, including laboratory and ultrasound assessment endothelial function. Results: complex evaluation showed arteriogenic impairment cavernosal circulation was primary pathogenic factor for...
Oxidative stress is one of the leading causes sperm dysfunction. Excessive amounts reactive oxygen species can damage membranes and disrupt their DNA integrity, which affects not only likelihood getting pregnant naturally, but also clinical outcomes assisted reproductive technologies risk miscarriage. Sperm cells are extremely vulnerable to oxidative stress, given limited functional reserve antioxidant systems repair apparatus. Lifestyle factors, most modifiable, often trigger generation...
This literature review is dedicated to surgical sperm retrieval techniques, such as percutaneous and microsurgical epididymal aspiration, testicular extraction (standard, microdissection, multifocal). Those methods allow men with azoospermia achieve biological parenthood, because gametes retrieved from testis or epididymis are usable for assisted reproduction. After laboratory processing of specimen the may be used intracytoplasmic injection and/or cryopreservation. In this article we...
Empirical therapy of male infertility is used as a stand-alone type treatment in idiopathic infertility, and other situations can complement basic therapy. There are well-known pathogenetic methods applied case reproductive gland infection, hypogonadotropic hypogonadism, ejaculation disorders. However, the prospects empirical not fully clear. Combined antioxidant drugs very popular, which include wide range similar substances. their molecules significantly differ from each structure,...
Novel coronavirus infection 2019 (COVID-19), which is caused by SARS-CoV-2 (severe acute respiratory syndrome related coronavirus-2), leads to a growing concern for public healthcare worldwide. Question about whether able penetrate into testicular tissue and/or seminal fluid remains unanswered. Fertility specialists also encounter many issues regarding prevention and treatment of infertility in patients with history COVID-19. There an increasing number publications demonstrate...
Introduction . There’re some pathological mechanisms of male fertility disorders that still don’t have proper diagnostic tests. This significantly decreases value a spermogram and makes the problem evaluation characteristics changes their effects on effectiveness assisted reproductive technologies (ART) pressing problem. The study objective is to identify correlation between ART programs changes, in particular sperm concentration, motility, morphology Materials methods. At V.I. Kulakov...
Aim. To study the relationship between severity of erectile dysfunction and anthropometric parameters obesity in patients with arterial hypertension. Materials methods. The included 71 different dysfunction, overweight grade 1obesity were analyzed, degree characteristics assessed according to data multispiral computed tomography (MSCT), a preliminary assessment function was performed using IIEF-5 questionnaire. Later questionnaire compared in-depth urological study: collection anamnesis,...
Male infertility accounts for 45-50% of all barren marriages, and in up to 40% cases an idiopathic male is diagnosed. The introduction ART programs into clinical practice allowed restore the childbearing function various diseases, both women men, which were previously considered absolutely unpromising treatment.to study influence antioxidant complex (Androdoz) on results HBA-test infertile men during a preparation assisted reproductive technology (IVF/ICSI).A total 80 aged from 25 45 years...
It has been found that men are infected with the coronavirus 1.5 times more often than women, but at same time 95% of them have mild infection. There questions require a scientific explanation: why and susceptible does virus cross blood-testicular barrier, can it be in seminal fluid, SARS-CoV-2 an effect on production androgens, is testicle affected what consequences this damage, direct virus-associated problems (such as social problems, isolation, quarantine, psychological sedentary...