A5030582788- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cerebral Palsy and Movement Disorders
- Exercise and Physiological Responses
- Infant Development and Preterm Care
- Eating Disorders and Behaviors
- Mindfulness and Compassion Interventions
- Health and Medical Studies
- Effects of Vibration on Health
- Behavioral Health and Interventions
- Functional Brain Connectivity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health, psychology, and well-being
- Adolescent and Pediatric Healthcare
- Transcranial Magnetic Stimulation Studies
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Neonatal and fetal brain pathology
- Neural and Behavioral Psychology Studies
- Cardiac Health and Mental Health
- Obsessive-Compulsive Spectrum Disorders
- Cellular transport and secretion
- Nutrition and Health in Aging
University Hospital Cologne
2017-2024
University of Cologne
2010-2024
ORCID
2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2023
Aim To create a reduced version of the 66‐item Gross Motor Function Measure (rGMFM‐66) using innovative artificial intelligence methods to improve efficiency administration GMFM‐66. Method This study was undertaken information from an existing data set children with cerebral palsy participating in rehabilitation programme. Different self‐learning approaches (random forest, support vector machine [SVM], and neural network) were evaluated estimate GMFM‐66 score fewest possible test items. Test...
Abstract Studies using transcranial magnetic stimulation with simultaneous electroencephalography (TMS-EEG) revealed an imbalance between cortical excitation and inhibition (E/I) in the dorsolateral prefrontal cortex (DLPFC) depression. As adolescence is a developmental period increase depression prevalence profound neural changes, it crucial to study relationship excitability adolescence. We aimed investigate of DLPFC adolescents dependency TMS-evoked potential N100 on severity. 36 clinical...
Anorexia nervosa (AN) is a highly debilitating disease which frequently results in chronification and often originates adolescence. Personality traits have been associated with the onset maintenance of AN; moreover, study indicated worse treatment outcome patients AN comorbid personality disorder (PD). However, research on PD adolescent scarce.The sample consists 73 female AN. We investigated symptom severity performing International Disorder Examination (IPDE) Eating Inventory 2...
Abstract Aim To compare the 66‐item Gross Motor Function Measure (GMFM‐66) with reduced version of GMFM‐66 (rGMFM‐66) respect to detection clinically relevant changes in gross motor function children cerebral palsy (CP). Method The study was a retrospective single centre analysis CP who participated rehabilitation programme. Overall, 1352 pairs and rGMFM66 measurements time interval 5 7 months were available. measure function, individual effect size (iES) calculated. Results population...
Movement as a Neuromodulator: How Physical Activity Influences the Physiology of Adolescent Depression
Introduction Rapid testing for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections was an essential step in reducing the spread of virus and monitoring pandemic development. Most mandatory standard Germany has been performed schools daycare facilities. We investigated influence behavioral attitudinal characteristics children caregivers on their acceptance (i) antigen-based nasal swab rapid (ii) oral saliva-based pooled Polymerase Chain Reaction (PCR) tests. Methods...
Pro-inflammatory cytokines (PICs) have gained attention in the pathophysiology and treatment of depressive disorders. At same time, therapeutic effect physical activity seems to work via immunomodulatory pathways. The interventional study "Mood Vibes" analyzed influence exercise on depression severity (primary endpoint) adolescents; PICs clinical outcome was as a secondary endpoint. Clinically diagnosed depressed adolescents (N = 64; 28.1% male; mean age 15.9; BMI 24.6) were included...
Prevalence of obesity increased noticeably during the last decades. Little is known so far about association between fat accumulation due to and skeletal muscle mass. The aim this study was describe mass after adjusting for relevant confounding factors in National Health Nutrition Examination Survey (NHANES) population children adolescents. We postulated a negative correlation lean body
Magnetic resonance imaging (MRI) is essential for studying brain development and psychiatric disorders in adolescents. However, the consistency remains challenging, highlighting need advanced methodologies to improve diagnostic research reliability this unique developmental period. Adolescence marked by significant neuroanatomical changes, distinguishing adolescent brains from those of adults making age-specific crucial understanding neuropsychiatric conditions youth. This study examines...
Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment adolescent depression. However, not only underlying neurobiological mechanisms, also influences placebo-related motivational factors (beliefs and expectancies sporting, enjoyment prior sports experiences), are still unclear. Based on data our study "Mood Vibes", we hypothesized that placebo-inherent like positive experiences factors, (positive beliefs, expectancies, related to PA), would increase effects...
Pediatricians frequently feel uncertain about their ability to detect early symptoms of child abuse and how respond in suspected cases.This study investigated the transactional stress model German pediatricians who experienced imagination stories with a protection scenario another potentially stress-triggering scenario.A two-part survey was conducted online. Each part included different story evaluation Stress Appraisal Measure (SAM), as well questions on protection, current problematics,...
People who are blind demonstrate remarkable abilities within the spared senses and compensatory enhancement of cognitive skills, underscored by substantial plastic reorganization in relevant neural areas. However, little is known about whether people with blindness form top-down models world on short timescales more efficiently to guide goal-oriented behavior. This electroencephalography study investigates this hypothesis at neurophysiological level, focusing contingent negative variation...
Regional Dual-energy X-ray absorptiometry (DXA) assessments are useful for patients where whole body measurements not feasible due to positioning difficulties because of anatomic anomalies (e.g. severe scoliosis) and artifacts neuroorthopedic hardware. Until now, there is a lack reference centiles bone mineral density composition lower limbs the DXA device Hologic Discovery model A densitometer. The study aimed generate age-and sex specific content (BMC), (BMD), lean mass (LBM), fat (FM)...
Abstract Endurance training has been shown to be effective in treating adolescents with major depressive disorder (MDD). To integrate endurance into the therapeutic setting and adolescents' daily lives, current performance status of should accurately assessed. This study aims examine MDD concerning exhaustion criteria during a cardiopulmonary exercise test (CPET), as well compare values obtained thereon sex- age-related control values. The included retrospective examination ((i) oxygen...
Background: A genetic influence for adolescent depression has been described in numerous studies. The product of the brain-derived neurotrophic factor gene (BDNF; rs6265 c.196G>A; p.Val66Met) identified playing an important role genesis and course depression. It interacts with serological BDNF other growth factors such as Insulin-like-Growth Factor 1 (IGF-1), influencing memory-associated brain regions (i.e. hippocampus, parahippocampal gyrus entorhinal cortex) well reward-related circuits...