A5018220909- Connective tissue disorders research
- Growth Hormone and Insulin-like Growth Factors
- Bone health and treatments
- Bone health and osteoporosis research
- Bone fractures and treatments
- Neurogenetic and Muscular Disorders Research
- Cerebral Palsy and Movement Disorders
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Alkaline Phosphatase Research Studies
- Effects of Vibration on Health
- Child and Adolescent Health
- Sexual Differentiation and Disorders
- Hip disorders and treatments
- Body Composition Measurement Techniques
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
- Vitamin D Research Studies
- Public Administration and Political Analysis
- Bone and Dental Protein Studies
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Medical and Health Sciences Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Childhood Cancer Survivors' Quality of Life
University Hospital Cologne
2015-2024
University of Cologne
2014-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2011-2020
Zentrum für Kinderheilkunde
1996-2017
Centrum für Integrierte Onkologie
2013-2017
TU Dortmund University
2016
University of Bonn
2016
Boston Children's Hospital
1993-2013
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin
2010
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2009
Data on blood pressure (BP) in children and adolescents with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency are conflicting the literature. BP data of n = 716 (aged 3–18 years) from a national CAH database were analyzed. adjusted for height compared contemporary reference data. A systolic diastolic above 95th centile was defined as hypertensive. Overall prevalence hypertension 12.5%. Prevalence higher younger than (18.5% vs. 4.9%). Until 8 years age,...
To identify parameters which predict individual growth response to recombinant human GH (rhGH) therapy and combine these in a prediction model.Fifty-eight prepubertal patients with deficiency (17 females) participated this prospective multicenter trial 1 year of follow-up.Auxological measurements, status markers bone metabolism were measured at baseline 1, 3 6 months after the start rhGH treatment. Correlations height velocity during first 12 treatment (HV+12) calculated. Prediction models...
Two new markers of bone resorption, the Collagen cross-linking amino acids pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in 24-h urine collections from 88 healthy children (45 females, 43 males; age 4 to 18 years) 17 adults. Normal values for pediatric use established these Parameters. Related daily excretion Creatinine PYD DPD about 3 6 fold higher groups than The collagen cross-links showed a highly significant correlation urinary hydroxyproline (OHP): r = 0.65 0.60 (p <...
Congenital adrenal hyperplasia (CAH) due to CYP21A2 gene mutations is associated with a variety of clinical phenotypes (salt wasting, SW; simple virilizing, SV; nonclassical, NC) depending on residual 21-hydroxylase activity. Phenotypes and genotypes correlate well in 80-90% cases. We set out test the predictive value CAH phenotype assignment based genotype classification large multicenter cohort. A retrospective evaluation genetic data from 538 patients (195 screened) collected 28 tertiary...
<h3>Objective</h3> In patients with pulmonary arterial hypertension (PAH), supportive therapies may be beneficial in addition to targeted medical treatment. Here, we evaluated the effectiveness and safety of oscillatory whole-body vibration (WBV) on stable PAH therapy. <h3>Methods</h3> Twenty-two (mean PAP≥25 mm Hg wedge pressure (PAWP)≤15 Hg) who were world health organization (WHO)-Functional Class II or III therapy for≥3 months, randomised receive WBV (16 sessions 1-hour duration within 4...
Precise assessment of motor deficits after traumatic spinal cord injury (SCI) in rodents is crucial for understanding the mechanisms functional recovery and testing therapeutic approaches. Here we analyzed applicability to a rat SCI model an objective approach, single-frame motion analysis, created used analysis mice. Adult female Wistar rats were subjected graded compression cord. Recovery locomotion was using video recordings beam walking inclined ladder climbing. Three out four parameters...
Treatment of children with growth disorders recombinant human hormone is necessary for improved outcomes, including final height.Adherence data from the Observational Study Saizen®-online, recorded easypod™ device collected between October 2009 and May 2011, were analyzed in pediatric patients receiving treatment a variety disorders.Data 75 (46 boys, 29 girls) different over period 343 ± 201 (SD) days. Boys girls showed similar mean SD adherence rates 90.5 3.1% 92.2 10.7%, respectively....
Parkinson's disease (PD) patients experience disabling motor dysfunctions as well non-motor symptoms (NMSs) that can highly impact their perceived quality of life. Besides pharmacological treatment options, active intervention programs have set some attention in managing these symptoms. However, previous studies mainly assessed the effectiveness on functional mobility and symptoms.This study aimed to investigate effect Lee Silverman Voice Treatment (LSVT) BIG, an intensified personalized...
Short small for gestational age (SGA) children can be affected by a lack of muscle mass rather than fat mass. They also face high risk the metabolic syndrome developing after childhood. It is not known whether low influences function.Our aim was to investigate muscle-fat distribution and function before during GH treatment in short SGA children.A total 34 prepubertal (11 females, seven with Silver-Russell syndrome) were included study. Mean values were: at start 7.3 yr; height sd score (SDS)...
Introduction: Individuals suffering from cerebral palsy (CP) often have involuntary, reflex-evoked muscle activity resulting in spastic hyperreflexia. Whole-body vibration (WBV) has been demonstrated to reduce reflex healthy subjects, but evidence CP patients is still limited. Therefore, this study aimed establish the acute neuromuscular and kinematic effects of WBV subjects with CP. Methods: 44 children were tested on activation kinematics before immediately after a 1 min-bout (16–25 Hz,...
Hypophosphatasia is characterized by the hypomineralization of bone associated with mutation tissue-nonspecific alkaline phosphatase (TNSALP) gene. Although disease usually autosomal recessive, an dominant form also recognized. Approximately 50 mutations have been found in TNSALP gene patients hypophosphatasia. However, identified to date do not seem account for dominantly inherited disease. We examined a German family which father and all 4 children were affected hypophosphatasia, whereas...
Leptin is a hormone which exclusively synthesized and secreted by adipocytes. As of yet, little known about the complex interplay hormones in modulation circulating leptin levels. To investigate effect growth (GH) therapy on leptin, serum concentrations were measured specific radioimmunoassay 29 children with GH deficiency (21 boys, 8 girls; age range 3–14 years) before after 1, 3 6 months treatment recombinant human GH. At baseline, levels identical to those healthy children. Serum...