A5006928955- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Fluorine in Organic Chemistry
- Biochemical and Molecular Research
- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Organophosphorus compounds synthesis
- Urological Disorders and Treatments
- Synthesis and biological activity
- Plant Virus Research Studies
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Protein Structure and Dynamics
- Radical Photochemical Reactions
- Bacterial Genetics and Biotechnology
- PI3K/AKT/mTOR signaling in cancer
- Blood groups and transfusion
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2016-2024
Cairo University
2023
University of Warsaw
2011-2012
Poznań University of Technology
2007
Al-Azhar University
1983
In the fight against cancer, researchers have turned their attention to eukaryotic initiation factor eIF4E, a protein whose increased level is strongly correlated with development and progression of various types cancer. Among numerous strategies devised tackle eIF4E overexpression, use 5′ end mRNA cap analogues has emerged as promising approach. Here, we present new candidates potent m7GMP for inhibiting translation interfacing eIF4E. By employing an appropriate strategy, synthesized doubly...
Abstract Background A urachal cyst has a rare incidence that been reported as 1/5,000 live birth. Case presentation We report two patients with complicated cyst, 5-year-old female who presented to the emergency department severe abdominal pain and 3-year-old presenting constipation. Upon laparoscopic exploration both had cysts which were adherent urinary bladder. Conclusion Complicated can present acute pain.
1,25-dihydroxyvitamin D(3) has quite significant anticancer properties, but its strong calcemic effect in principle excludes it as a potential drug. Currently, lot of effort is being devoted to develop potent analogs that would not induce hypercalcemia during therapy. In this work, the free binding energy VDR receptor with and three (EB 1089, KH 1060 RO 25-9022) calculated compared each other. With approach, we could estimate relative affinity most analog, 25-9022, also revealed distinct...
Activation-induced cytidine deaminase (AID) is known for its established role in antibody production. AID induces the diversification of antibodies by deaminating deoxycytidine (C) within immunoglobulin genes. The capacity to deaminate 5-methyldeoxycytidine (5 mC) and/or 5-hydroxymethyldeoxycytidine hmC), and consequently involvement active DNA demethylation, not fully resolved. For instance, structural determinants activity on different substrates remain be identified. To better understand...
Understanding the interactions of epothilones with β-tubulin is crucial for computer aided rational design macrocyclic drugs based on and epothilone derivatives. Despite numerous structure-activity relationship investigations we still lack substantial knowledge about binding mode their derivatives to β-tubulin. In this work, reevaluated electron crystallography structure A/β-tubulin complex (PDB entry 1TVK) proposed an alternative A that explains more experimental facts.
Protein kinases control diversity of biochemical processes in human organism. Checkpoint 1 kinase (Chk1) is an important element the checkpoint signalling pathways and responsible for DNA damage repair. Hence, this plays essential role cancer cells survival has become target anticancer agents. Our previous investigations showed that some arylsulphonyl indazole derivatives displayed effect vitro. In present study, order to verify possibility interactions pyrazole with Chk1, we focused on...
Mitsunobu reaction of partially acylated uridine proceeds with high regioselectivity for intramolecular SN2 anhydro linkage closuring. Under the conditions, an isomeric mixture diacyl derivatives either free 2'- or 3'-hydroxyl group was transformed into a single cyclonucleosidic product, 2,2'-anhydro-3',5'-di-O-acyluridine. This paper presents possible mechanism reactions, explanation observed phenomenon based on semiempirical and density functional theory (DFT) calculations utility this...
The ribosome is subjected to post-translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal elements, the P-proteins undergo phosphorylation within C terminus, element which interacts with trGTPases or ribosome-inactivating proteins (RIPs); however, role of has never been elucidated. Here, we probed function on interaction RIPs using P1-P2 dimer. We determined kinetic parameters toxins biolayer interferometry and microscale thermophoresis....
Experimental methods based on DNA and RNA hybridization, such as multiplex polymerase chain reaction, ligation-dependent probe amplification, or microarray analysis, require the use of mixtures multiple oligonucleotides (primers probes) in a single test tube. To provide an optimal reaction environment, minimal self- cross-hybridization must be achieved among these oligonucleotides. address this problem, we developed EvOligo, which is software package that provides means to design group...
Abstract Molecular mechanics (MM/Ambers) calculations were applied to probe the conformational profile of open‐chain epothilone analogue [Org Lett 2006, 8, 685], cytotoxic against some cell lines. Geometries most stable conformers optimized at DFT level using B3LYP functional and then compared known both experimental virtual epothilone. One structures is III (1.47 kcal/mol above global minimum) which represents high similarity appropriate fragment Taylor's model A, but two other conformers:...
Virus-like particles (VLPs), due to their nanoscale dimensions, presence of interior cavities, self-organization abilities and responsiveness environmental changes, are interest in the field nanotechnology. Nevertheless, comprehensive knowledge VLP self-assembly principles is incomplete. formation governed by two types interactions: protein–cargo protein–protein. These interactions can be modulated physicochemical properties surroundings. Here, we used brome mosaic virus (BMV) capsid protein...
Synthesis of a series 3-hydroxynaphthalene-2-carbonylamino acid methyl esters (II-XI) and some their corresponding hydrazides (XII-XXI), dipeptide (XXII-XXXV) (XXXVI-XXXIX) is described. 3-Hydroxynaphthalene-2-CO-L-Tyr-N2H3 (XX) the L-Val-L-Ala-N2H3 (XXXVI) were found to be active against number micro-organisms.