A5101545192- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Cancer Risks and Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroblastoma Research and Treatments
- Macrophage Migration Inhibitory Factor
- Voice and Speech Disorders
- Cancer-related Molecular Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian cancer diagnosis and treatment
- Cardiac tumors and thrombi
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
Northwestern University
2025
State Key Laboratory of Oncology in South China
2024
Hebei Medical University
2024
Key Laboratory of Guangdong Province
2024
Jilin University
2018-2020
First Hospital of Jilin University
2018-2020
Weatherford College
2020
To build a predictive scoring model based on simple immune and inflammatory parameters to predict postoperative survival in patients with breast cancer.We used brand-new immuno-inflammatory index-pan-immune-inflammation value (PIV)-to retrospectively evaluate the relationship between PIV overall (OS), results of Cox regression analysis, we established prediction several independent prognostic parameters. The accuracy was evaluated independently validated.A total 1,312 were included for...
Background: Neutrophil extracellular traps (NETs) are closely associated to tumorigenesis and development. However, the relationship between NETs-related long non-coding RNAs (lncRNAs) characteristics of breast tumor remains an enigma. This study aimed explore clinical prognostic value lncRNAs, their correlation with microenvironment (TME) predictive ability drug sensitivity in patients cancer (BC). Methods: The expression profiles RNA-sequencing relevant data BC were extracted from TCGA...
Objectives: We aim to determine the feasibility, safety, maximally tolerated dose (MTD), recommended and potential anti-tumor activity of intrathecal pemetrexed (IP). Materials Methods: Lung adenocarcinoma patients with recurrent or progressive leptomeningeal metastases (LM) after chemotherapy were recruited. IP was escalated from 10 mg. A minimum three a maximum six enrolled in each cohort. Schedule protocol twice per week for 2 weeks induction therapy, followed by once 4 consolidation...
The hemoglobin-albumin-lymphocyte-platelet (HALP) score functions as a comprehensive index that assesses the systemic inflammatory response, nutritional, and immune status. This study aimed to explore relationship between preoperative HALP prognosis of BC patients develop predictive nomograms.
Background: The C-reactive protein-albumin-lymphocyte (CALLY) score is a novel indicator associated with inflammation, immunity, and nutrition, utilized for cancer prognostic stratification. This study aimed to evaluate the integrated significance of pre-treatment CALLY Epstein-Barr virus (EBV) DNA levels in nasopharyngeal carcinoma (NPC) patients develop models. Patients Methods: A total 1707 NPC from September 2015 December 2017 were retrospectively enrolled. cut-off point score,...
A phase I/II study of intrathecal pemetrexed (IP) combined with involved-field radiotherapy (IFRT) was performed to determine feasibility, safety, and antitumor activity for leptomeningeal metastases (LM) from solid tumors.Participants first received induction IP administration, followed by concomitant within 3 days. The regimen consisted (pemetrexed 10 mg, dexamethasone 5 once per week, 4 times in weeks) IFRT (40 Gy 20 fractions). Six participants were recruited assess feasibility I, then...
Drug resistance constitutes one of the principal causes poor prognosis in breast cancer patients. Although cells can maintain viability independently mitochondrial energy metabolism, they remain reliant on functions for synthesis new DNA strands. This dependency underscores a potential link between metabolism and drug resistance. Hence, metabolism-related differentially expressed genes (DMRDEGs) may emerge as candidates novel biomarkers. study endeavors to assess DMRDEGs biomarkers or...
The nutritional risk index (NRI) is an independent prognostic factor for overall survival in various cancers, but its value breast cancer remains unclear. This study aimed to explore the relationship between NRI and (OS) develop a predictive nomogram.We retrospectively enrolled 1347 patients who underwent mastectomy or lumpectomy January 2011 November 2012. Using cutoff of 110.59, were divided into high-NRI group low-NRI group. OS was compared two groups. Clinicopathological factors...
Background: High grade glioma, also known as glioblastoma multiform (GBM) a highly aggressive brain tumor, requires advanced systems to study tumor-stroma interactions. Paired in vitro and vivo model such 3D organoids PDOX models derived from EGFP-SCID mice offered unique opportunity precisely rapidly differentiation of mouse (EGFP positive) human tumor cells, thereby facilitating the visualization analysis tumor/normal cell interactions vivo. Methods: received intra-cranial implantation...
2073 Background: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brain tumor, with two-year survival less than 10%. Radiation therapy (XRT) offers limited benefits, and effective therapies are urgently needed. This study investigates the FDA-approved CDK4/6 inhibitors-Abemaciclib, XRT, temozolomide (TMZ) as therapeutic regimen for DIPG using organoids patient-derived orthotopic xenograft (PDOX) models, aiming to improve outcomes gain insights into underlying cellular...
Background: Leptomeningeal metastasis (LM) has frequently been observed in patients with lung adenocarcinoma. So far, its diagnosis and disease course monitoring are still extremely difficult. Moreover, there is no effective treatment regimen for LM due to a lack knowledge on the molecular mechanism of LM. This study aimed identify LM-related cerebrospinal fluid (CSF) miRNAs, which have potential value diagnosing exploring mechanism. Methods: CSF miRNAs were screened verified by microarray...
Treatment options for patients with triple-negative breast cancer (TNBC) remain limited to mainstay therapies owing a lack of efficacious therapeutic targets. Accordingly, there is an urgent need discover and identify novel molecular targets the treatment diagnosis this disease. In study, we analyzed correlation telomerase reverse transcriptase (TERT) methylation status TERT expression, prognosis, immune infiltration in TNBC identified role regulation prognosis immunotherapy.
Abstract Purpose As a rare type of tumor, the metastasis pattern large cell neuroendocrine carcinoma (LCNEC) is still unclear. Our aim was to investigate metastatic patterns and develop predictive model prognosis in patients with advanced LCNEC. Methods Patients LCNEC diagnosed between 2010–2015 from Surveillance, Epidemiology End Results (SEER) database were retrospectively included. Chi-square test used for baseline characteristics analysis. Survival differences assessed using Kaplan–Meier...
Laryngeal granulomas are benign lesion that rarely occurs after surgery of laryngeal cancer. Until now there has not been standard treatment for it.The patient was diagnosed with neoplasm one and half a month ago. Endoscopic low-temperature plasma knife in the radical excision left vocal cord performed under general anesthesia. Postoperative histopathological examination confirmed tumor highly differentiated invasive squamous cell carcinoma (SCC). Then suffered unexplained intermittent...
Abstract Aims: FGFR2+ fibroblasts were reported to promote tumor progression, but the mechanisms remained unexplored in esophageal squamous cell carcinoma (ESCC).Methods: Multiplex immunohistochemistry (mIHC) displayed distributions of and cancer stem cells (CSCs). After fibroblast isolation, stimulated with supernatant assess radioresistance CSC properties. RNA-seq analysis identified downstream BMP5 expression.Results: In our preliminary study, results showed that always represented area...
<title>Abstract</title> Background: Drug resistance constitutes one of the principal causes poor prognosis in breast cancer patients. Cancer cells can survive independently energy provided by mitochondria; however, they are incapable synthesizing new DNA strands without mitochondrial involvement.This may suggest that metabolism could be related to drug resistance. Hence, and metabolism-related differentially expressed genes (DMRDEGs) emerge as candidates for novel biomarkers. This study...
Background: Renal cell carcinoma (RCC) is one of the three major malignant tumors urinary system, and clear renal (KIRC) most common pathological type RCC. HAPLN3 plays an important role in occurrence development various tumors. But its relationship with KIRC remains unclear. Therefore, our study aims to explore pathogenesis investigate potential mechanism.Methods: data from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were used determine whether was differentially...
Abstract BACKGROUND The role of involved-field radiation therapy (IFRT) and intrathecal chemotherapy (IC) in leptomeningeal metastasis (LM) from solid tumors was gradually underestimated the era targeted therapy. This study aimed to investigate safety effectiveness concurrent IFRT methotrexate (MTX)/cytarabine (Ara-C) for LM, particularly those who developed LM while receiving METHODS Enrolled patients were randomly assigned two subgroups (IFRT&IC-MTX IFRT&IC-Ara-C), first treated...
To determine toxicities, maximally tolerated dose (MTD), and potential antitumor activity of intrathecal pemetrexed (IP). MATERIAL AND Pulmonary adenocarcinoma patients with recurrent or progressive leptomeningeal metastases (LM) after chemotherapy other LM-related therapy were included. IP doses escalated from 10 mg to 15 mg, even 20 mg. Protocol schema was twice per week for 2 weeks (induction therapy), followed by once 2–4 (consolidation therapy). The primary endpoints MTD safety....
We hope to identify leptomeningeal metastasis (LM)-related cerebrospinal fluid (CSF) miroRNAs as potential molecular markers contributing diagnosis of LM patients with lung adenocarcinoma. MATERIAL AND CSF samples were collected from adenocarcinoma (positive group) and non-LM (negative group). Meanwhile, matching other before after effective LM-related treatment. Samples screening using Agilent Human microRNA arrays. Differentially expressed microRNAs in both two sets well significantly...
Abstract Background: This study aimed to compare the use of radiotherapy (RT) in gastric cancer (GC) patients from SEER database and established a nomogram assess cancer-specific survival (CSS). Methods: Patients between 2004 2013 were analyzed. Survival was analyzed by Kaplan-Meier curves log-rank test. Prognostic factors multivariate Cox analysis screened construct nomogram. The performance validated via concordance index (C-index), calibration plots, decision curve analyses (DCAs)....