A5066353296- Immune Cell Function and Interaction
- Immune cells in cancer
- Genomics and Chromatin Dynamics
- Salivary Gland Tumors Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- T-cell and B-cell Immunology
- Ear and Head Tumors
- Polyamine Metabolism and Applications
- Plant Virus Research Studies
- Cardiac Valve Diseases and Treatments
- Oral and Maxillofacial Pathology
- Diabetes and associated disorders
- Marine and fisheries research
- Adipose Tissue and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Galectins and Cancer Biology
- Fish Biology and Ecology Studies
- Enzyme Structure and Function
- Fish Ecology and Management Studies
- Signaling Pathways in Disease
- Redox biology and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Protist diversity and phylogeny
Sidney Kimmel Comprehensive Cancer Center
2025
Johns Hopkins University
2023-2025
Bloomberg (United States)
2023-2025
Max Planck Institute of Immunobiology and Epigenetics
2021-2024
University of Freiburg
2022
Fundación Ciencias Exactas y Naturales
2018
University of Buenos Aires
2018
Consejo Nacional de Investigaciones Científicas y Técnicas
2018
University Medical Center Freiburg
2015
Roswell Park Comprehensive Cancer Center
2015
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study adaptation CD8 + T intestinal microenvironment and how this process shapes establishment cell pool. progressively remodel their transcriptome surface phenotype as they enter gut wall, downregulate expression mitochondrial genes. Human mouse have reduced mass, but maintain a viable energy balance sustain function. We find that is rich in prostaglandin E 2 (PGE ), which drives...
Abstract The behaviour of Dictyostelium discoideum depends on nutrients 1 . When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into multicellular organism 2,3 This biology makes D. an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species—generated as consequence nutrient limitation—lead to the sequestration cysteine antioxidant glutathione....
The identification of effective new therapies for prostate cancer (PCa) requires a better understanding the multiple molecular interactions between tumor cells and their associated microenvironment. In this context, galectin-1 (Gal-1) is key molecule in determination prostatic carcinoma microenviroment; therefore, it essential to understand all processes which protein involved. Most previous studies found literature have focused on microenvironment remodeling properties tumor-secreted Gal-1,...
Abstract The eukaryotic genome is packed into nucleosomes of 147 base pairs around a histone core and organized euchromatin heterochromatin, corresponding to the A B compartments, respectively 1,2 . Here we investigated whether individual contain sufficient information for 3D genomic organization example, in their biophysical properties. We purified native mononucleosomes high monodispersity used physiological concentrations polyamines determine condensability. chromosomal regions known...
The eukaryotic genome, first packed into nucleosomes of about 150 bp around the histone core, is organized euchromatin and heterochromatin, corresponding to A B compartments, respectively. Here, we asked if individual in vivo know where go. That is, do mono-nucleosomes by themselves contain A/B compartment information, associated with transcription activity, their biophysical properties? We purified native high monodispersity used physiological concentrations biological polyamines determine...
Predictive regression equations were generated to estimate total length of the stripped weakfish (C. guatucupa) using skull and pectoral girdle bones, specific body otolith lengths. Regressions lengths all statistically significant. The bone external features´ regressions evidently have capability increase amount dietary information obtainable from stomach contents analyses Southwest Atlantic piscivore organisms.
Immune cells must adapt to different environments during the course of an immune response. We studied adaptation CD8
Abstract Fatty acid oxidation (FAO) is upregulated in IL-4-stimulated (alternatively activated) macrophages (M(IL-4)). We examined the effect of loss function enzyme Cpt1a, which facilitates entry long chain fatty acids (FA) into mitochondria for FAO, on alternative activation. Expression M(IL-4) markers ARG1, CD301 and RELMα, was impaired tamoxifen-treated ERT2Cre x Cpt1a fl/fl expressing shRNA targeting (Cpt1a- shRNA). In contrast, Vavi Cre Lysm responded normally to IL-4. Reduced...
Carcinoma adenoquístico de las glándulas salivales Adeno cystic carcinoma of salivary glandsAntecedentes: el es tumor maligno más frecuente submaxilar y menores.A pesar su lento crecimiento diseminación regional, muestra un pronóstico desfavorable debido a tardía distancia.Objetivo: analizar la serie propia luz bibliografía.Material métodos: 44 pacientes con una edad media 52,47 años predominio del género femenino.De ellos, 61,3% fueron tumores glándula salival menor, 20,4% 18,2% parótida.En...