A5100655281- Catalytic C–H Functionalization Methods
- Membrane Separation Technologies
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Solar-Powered Water Purification Methods
- Electrohydrodynamics and Fluid Dynamics
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Surface Modification and Superhydrophobicity
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Membrane-based Ion Separation Techniques
- Synthesis and Biological Evaluation
- Environmental Quality and Pollution
- Remote Sensing and Land Use
- Graphene and Nanomaterials Applications
- Synthesis of Indole Derivatives
- Synthesis and Characterization of Pyrroles
- RNA and protein synthesis mechanisms
- Antimicrobial Resistance in Staphylococcus
- Advanced Synthetic Organic Chemistry
- MXene and MAX Phase Materials
- Carbon dioxide utilization in catalysis
Sir Run Run Shaw Hospital
2022-2024
Zhejiang University
2018-2024
Nanjing Tech University
2024
Hangzhou Medical College
2021-2023
Cubist Pharmaceuticals (United States)
2011
Myxopyronin B (MyxB) binds to the switch region of RNA polymerase (RNAP) and inhibits transcriptional initiation. To evaluate potential development MyxB as a novel class antibiotic, we characterized antimicrobial activity against Staphylococcus aureus. Spontaneous resistance in S. aureus occurred at frequency 8 × 10(-8) , similar that rifampin. The MyxB-resistant mutants were found be altered single amino acid residues RNAP subunits form MyxB-binding site. In presence human serum albumin,...
Abstract In the last 20 years, efficient transition metal catalysts for α‐arylation of enolates have been introduced. Despite popularity and utility these reactions, there remains room improvement (reduced costs, elimination metals specialized ligands). Herein is reported a general, scalable green method aroylation simple diarylmethane pronucleophiles through direct acyl C−N cleavage N ‐Bn− ‐Boc arylamides ‐acylpyrroles under metal‐free conditions. Importantly, 1 : ratio amide to...
Chemoselectivity is one of the most challenging issues facing chemical sciences.
Abstract Due to amine derivatives widely existing in numerous clinical medicines and bioactive compounds, their synthesis has received considerable attention over the past few decades. Traditional methods for of largely relied on reduction nitroarenes, amides, hydrazines, nitriles, azides. Recently, discovery 2‐azaallyl anions as super‐electron‐donors (SEDs) opened up new possibilities construction diverse carbon‐carbon carbon‐heteroatom bonds through radical coupling strategies. This...
Abstract The use of nitroarenes as amino sources in synthesis is challenging. Herein reported an unusual, straightforward, and transition metal-free method for the net [3 + 2]-cycloaddition reaction 2-azaallyl anions with nitroarenes. products this are diverse 2,5-dihydro-1,2,4-oxadiazoles (>40 examples, up to 95% yield). This does not require external reductant reduce nitroarenes, nor it employ nitrosoarenes, which often used N–O cycloadditions. Instead, proposed that anions, behave...
Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds.
An efficient direct C(sp3)⁻H oxidation of diarylmethanes has been demonstrated by this study. This method employs environment-friendly O₂ as an oxidant and is promoted commercially available MN(SiMe₃)₂ [M = K, Na or Li], which provides a facile for the synthesis various diaryl ketones in excellent yields. protocol metal-free, mild compatible with number functional groups on substrates.
The imide moiety is a well-known structural motif in bioactive compounds and useful building block variety of processes.
Toluene derivatives are alkyl aromatic hydrocarbons derived from oil and natural gas among the cheapest most readily available materials for chemical industry.C-H functionalization is important synthesis of various bioactive substances, inert benzylic hydrocarbon bond activation has long been a big challenge in this field due to high energy.Therefore, development simple efficient methods C-C C-X bonds formation demonstrated as one hot topics by activating C(sp 3 )-H recent years.The progress...
To develop efficient method for the synthesis of quinazolinone derivatives bearing different functional groups on ring A and B evaluation as neuroprotective agents.Synthetic route to was furnished by condensation/cyclocondensation/ reduction sequence activated N-acylbenzotriazoles. The structures targets compounds have been deduced upon their spectral data (1HNMR, 13CNMR Mass spectroscopy). activities synthesized are also evaluated.Preliminary screening a MPP+ induced SH-SY5Y cell injury...
With the development of urban afforestation, increasing garden waste has become a seriously problem. There are lot limitations by traditional approaches to utilization and therefore it’s urgent need explore new method for utilization. To solve problem using waste, we produce composite material called fungal mycelium materials at room temperature which based on straw. And is comprised substrate discrete particles network interconnected mycelia cells bonding together. In order obtain shorter...
碳氢键选择性活化是化学领域中最基本和最具挑战性的问题之一，在合成各种生物活性物质中具有重要的作用. 羧酸及其衍生物是最易获得的原料之一. 通常羧酸的α-和β-C(sp3)–H键官能化较为容易，而γ-和δ-C(sp3)–H因距离较远则难以官能化. 因此，发展简便、高效的方法实现羧酸及其衍生物远程C(sp3)–H键官能团化成为近年研究热点之一. 本文根据不同反应分类, 综述了近些年在不同催化条件下基于羧酸衍生物的远程γ-C(sp3)–H键官能团化反应研究进展, 详细讨论了反应底物普适性、反应机理和应用, 并对该领域的发展前景和局限性进行了总结.
Abstract: In recent years, nitroarenes have been extensively exploited as green, efficient electrophilic arylation reagents used in a variety of organic syntheses. Transition-metal-free cross-coupling reactions and vicarious nucleophilic substitution (VNS) become practical reliable synthetic methods to access momentous functionalized compounds. Thus, the introduction various substituents into has attracted considerable attention important approaches due their simplicity practicality. this...
In this study, the first highly chemoselective amidation of Boc and amide groups N -R- -Boc arylamides is advanced.