A5103074301- Algebraic and Geometric Analysis
- Curcumin's Biomedical Applications
- Mathematical Analysis and Transform Methods
- Traditional Chinese Medicine Analysis
- Genetic factors in colorectal cancer
- Finite Group Theory Research
- Antibiotic Resistance in Bacteria
- Advanced Algebra and Geometry
- Pharmacological Effects of Natural Compounds
- Catalytic Cross-Coupling Reactions
- Medicinal Plant Pharmacodynamics Research
- Acne and Rosacea Treatments and Effects
- Ocular Surface and Contact Lens
- Plant-derived Lignans Synthesis and Bioactivity
- Advanced Mathematical Theories and Applications
- Advancements in Transdermal Drug Delivery
- Neuropeptides and Animal Physiology
- Cancer Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
- Periodontal Regeneration and Treatments
- Hormonal Regulation and Hypertension
- Ocular Diseases and Behçet’s Syndrome
- biodegradable polymer synthesis and properties
- Neonatal Health and Biochemistry
Zhejiang University
2006-2024
Sir Run Run Shaw Hospital
2016-2024
North China University of Science and Technology
2015-2017
Nanjing Medical University
2013
Nanjing University
2013
The aim of this study was to develop ethosomes loaded with cryptotanshinone (CPT) and formulate them as a topical gel for the treatment acne. Ethosomes were prepared evaluated vesicle size, CPT loading encapsulation efficiency. Optimized formulated Carbomer 974 gels compared conventional hydroethanolic transdermal permeation skin deposition in vitro. anti-acne activity irritation investigated rabbits. had an average size 69.1 ± 1.9 nm efficiency 0.445 0.007 mg/mL 40.31 0.67%, respectively....
ObjectiveWe conducted this multicenter retrospective study to evaluate the prevalence, clinical patterns, and risk factors for tigecycline-induced liver injury, which is a type of drug-induced injury (DILI).MethodsInpatients receiving intravenous tigecycline ≥7 days were included. Patient information was collected assess possible DILIs. The pattern severity DILI evaluated. A multivariable logistic regression model used identify independent associated with DILI.ResultsA total 986 patients...
A new neolignan, (-)-(7R,8S,7'E)-3',4-dihydroxy-3-methoxy-8,4'-oxyneoligna-7'-ene-7,9,9'-triol(1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans,trans-2,8-diene-4,6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4,6-diyn-1-ol (3), lobetyol (4), lobetyolin (5),dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures 1-8 elucidated by...
Topical anti-infectives are important in the management of ocular infections, but little is known about their current status and trends use China. Thus, we carried out a prescription-based, cross-sectional study using database Hospital Prescription Analysis Projection China, aimed to analyze trend topical for outpatients ophthalmology department from 2013 2019. A total 2,341,719 prescriptions 61 hospitals located six major areas written by ophthalmologists were identified, 1,002,254...
The aim of this study was to assess the patterns and trends pharmacological treatment for outpatients with postherpetic neuralgia (PHN) in China period 2015-2019. Prescription data PHN were extracted from database Hospital Analysis Program according inclusion criteria. yearly prescriptions corresponding costs analyzed stratified by drug class specific drugs. A total 19,196 49 hospitals 6 major regions included analysis. increased 2534 2015 5676 2019 (p = 0.027), expenditures CNY 898,618...
Pediatric hypertension become an early marker of cardiovascular diseases, but their antihypertensive drug use patterns are rarely known.To investigate the epidemiological characteristics pediatric and drugs in real world China.In this study, demographic, diagnosis, medication prescription data including types comorbidities, were analyzed. The evaluated according to Chinese guidelines for hypertension.1301 prescriptions (number visits) containing 1880 medical orders collected. average number...
Pembrolizumab is superior to chemotherapy as a first-line treatment for patients with mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced metastatic colorectal cancer (CRC), significant long-term survival benefit according the KEYNOTE-177 trial. The current study aimed determine whether pembrolizumab cost-effective dMMR/MSI-H CRC in China.A partitioned model (PSM) was developed simulate based on progression-free (PFS), progressive disease (PD) and death....
The objective of this study was to assess the status and trends antiviral treatment in outpatients with herpes zoster China.Prescription data on drugs were extracted from database Hospital Prescription Analysis Program China according inclusion criteria. Yearly prescriptions costs calculated, analyzed. further stratified by age, sex, specific drug use. distribution defined daily (DDCs) valaciclovir famciclovir analyzed, median DDCs identified.A total 132,911 49 hospitals located six major...
A result of A. Joseph says that any nilpotent or semisimple element $z$ in the Weyl algebra $A_1$ over some algebracally closed field $K$ characterstic 0 has a normal form up to action automorphism group $A_1$. It is shown this note corresponds unique pair integers $(k,n)$ with $k\ge n\ge 0$, and will be called norm $z$. Similar results for symplectic Poisson $S_1$ are obtained. The Dixmier conjecture can reformulated as follows: For $z\in A_1$ whose $k>n\ge 1$, there exists no $w\in $...
To evaluate the prescribing trends of fixed-dose combination antibiotics not recommended by WHO (FNRs) for intensive care unit (ICU) patients in six major areas China from 2013 to 2019.
Abstract: In recent years, nitroarenes have been extensively exploited as green, efficient electrophilic arylation reagents used in a variety of organic syntheses. Transition-metal-free cross-coupling reactions and vicarious nucleophilic substitution (VNS) become practical reliable synthetic methods to access momentous functionalized compounds. Thus, the introduction various substituents into has attracted considerable attention important approaches due their simplicity practicality. this...
Lenvatinib (LEN) combined with immune checkpoint PD-1 blockade is among the most effective treatment strategies for advanced hepatocellular carcinoma (HCC) and has been deemed a breakthrough therapy by Food Drug Administration. However, this strategy associated disadvantages such as non-tumor targeted aggregation low oral bioavailability after long-term administration of LEN, some patients show poor responses to immunotherapy well. To overcome these drawbacks, SP94 peptide-modified...
Abstract Background Pembrolizumab is superior to chemotherapy as a first-line treatment for patients with mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced metastatic colorectal cancer (CRC), significantly long-term survival benefit trend by KYENOTE-177. The current study aimed determine whether pembrolizumab cost-effective dMMR/MSI-H CRC in China. Methods A partitioned model (PSM) was developed simulate based on health states of progression-free (PFS),...
Based on the results people have obtained, we try to prove Jacobian conjecture, but there is a gap in proof.