A5050835346- Dermatologic Treatments and Research
- Phytochemistry Medicinal Plant Applications
- Phytochemicals and Antioxidant Activities
- Skin Protection and Aging
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Agricultural and Food Sciences
- melanin and skin pigmentation
- Phytochemistry and Bioactivity Studies
- Traditional and Medicinal Uses of Annonaceae
- Bee Products Chemical Analysis
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Antioxidant Activity and Oxidative Stress
- Facial Rejuvenation and Surgery Techniques
- Synthesis and biological activity
- Wound Healing and Treatments
- Phytochemistry and Biological Activities
- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Cancer therapeutics and mechanisms
- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
Universidade Federal do Amazonas
2016-2025
Hospital de Base
2007-2025
Faculdade de Medicina de São José do Rio Preto
2004-2025
Biolog (United States)
2025
Instituto de Ciências Farmacêuticas
2012-2024
Planta
2023
Centre de Référence Déficits Immunitaires Héréditaires
2023
National Institute of Amazonian Research
2021-2023
Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2023
Terra
2023
A class of drugs in use for treating type II diabetes mellitus (T2D), typified by the pseudotetrasaccharide acarbose, act inhibiting α-glucosidase activity present pancreatic secretions and brush border small intestine. Herein, we report synthesis a series 4-substituted 1,2,3-triazoles conjugated with sugars, including d-xylose, d-galactose, d-allose, d-ribose. Compounds were screened inhibitory using yeast maltase (MAL12) as model enzyme. Methyl-2,3-O-isopropylidene-β-d-ribofuranosides,...
Melasma is a chronic skin disorder that results in symmetrical, blotchy, brownish facial pigmentation. It more common women than men, it generally starts between 20 and 40 years, can lead to considerable embarrassment distress. The aims of this article evaluate the treatment with microneedling method 18 female 4 male recalcitrant melasma. All patients demonstrated good results. In conclusion, microneedles appears be promising therapeutic for
Thiol groups have been described as the main responsible for antioxidative effects of plasmatic proteins. Also, thiol serum levels shown a positive correlation with total antioxidant capacity (TAC) in many studies. Measurement TAC by substract oxidation-based methods widely used reference to measure status; however, cases these are inexact or imprecise, usually when performed manual procedures. In this paper we describe simple automated procedure determination thiols serum, which was based...
The pathogenesis of Nonalcoholic Fatty Liver Disease remains largely unknown, but oxidative stress seems to be involved. aim this study was evaluate the role in experimental hepatic steatosis induced by a choline-deficient diet.Fatty liver disease Wistar rats diet. animals were randomized into three groups: I (G1) and II (G2), n=6 each--fed with diet for four twelve weeks respectively; Group III (control-G3; n=6)--fed standard weeks. Samples plasma submitted biochemical, histological...
Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening not known. This study aimed to investigate clinical histologic alterations promoted by in facial melasma. Open pilot trial including six women with refractory melasma submitted two sessions (1.5 mm) each 30 days followed daily triple combination broad-spectrum...
Copaifera spp. are Amazonian species widely studied and whose oleoresins used by local people for various medicinal purposes. However, a detailed study of the activity main phytochemical components these remains to be done. Here, we cytotoxicity in vitro anti-inflammatory effects six diterpene acids: copalic, 3-hydroxy-copalic, 3-acetoxy-copalic, hardwickiic, kolavic-15-metyl ester, kaurenoic, isolated from The diterpenes did not show normal cell lines, nor they significant changes viability...
The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. Artemisia annua, respectively). synthetic quinoline (e.g. chloroquine) semi-synthetic derivatives artesunate) developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum vivax drug-resistance of concern. There an urgent need for new anti-malarials. Traditionally Amazonian may provide treatments drug-resistant P. falciparum. Herein, in vitro...
Nitric oxide (*NO) is a pervasive free radical species that concentrates in lipophilic compartments to serve as potent inhibitor of lipid and low-density lipoprotein oxidation processes. In this study, we synthesized, characterized, detected nitrated derivatives linoleic acid (18:2) human blood plasma using high-pressure liquid chromatography coupled with electrospray ionization tandem mass spectrometry. While the reaction nitronium tetrafluoroborate 18:2 presented ions mass/charge (m/z)...
Oxidative stress has been implicated in the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD). Vitamin C and vitamin E are known to react with reactive oxygen species (ROS) blocking propagation radical reactions a wide range oxidative situations. The potential therapeutic efficacy antioxidants NAFLD is unknown. aim this study was evaluate role antioxidant drugs (vitamin or E) its prevention.Fatty liver disease induced Wistar rats by choline-deficient diet for four weeks. were randomly...
Acute tubular necrosis (ATN) is usually studied as a single entity, without distinguishing between ischaemic, nephrotoxic and mixed aetiologies. In the present study we evaluated characteristics outcomes of patients with ATN by aetiological group. We conducted retrospective comparison clinical features, mortality rates risk factors for three types in admitted to general intensive care unit university hospital 1997 2000. Of 593 acute renal failure, 524 (88%) were classified having ATN. Their...
Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels pivotal correlate them with clinical parameters. Serum samples from 53 psoriasis patients 35 healthy volunteers, matched the proportion sex age ratios, were collected for ELISA cytokine detection. Area Severity Index (PASI) assessed at time sampling patients. Our findings demonstrate that IL-17A, IL-22, IL-6...
To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency.The study group consisted 15 residents from Anesthesiology Surgery areas, both genders, mainly exposed isoflurane a lesser degree sevoflurane nitrous oxide; control young adults not anesthetics. Blood samples were drawn residency (eight, 16 22 months gases). DNA damage was evaluated by comet assay, defense assessed total...
Objective: Obesity and metabolic syndrome are preventable complex-multifactorial disorders that severely increase risk of cardiovascular disease (CVD). Indoleamine 2,3-dioxygenase (IDO) enzyme converts tryptophan (TRP) to kynurenine (KYN); besides, KYN/TRP ratio has been shown predict major coronary events all-cause mortality in patients with artery disease. However, their role is not understood. Methods: In a cross-sectional study (n = 161, mean population age years 32 ± 7.5, sex 53%...
In the context of developing a new natural product-based cosmetic, in vitro efficacy and safety evaluations complex botanical mixture based on Eugenia dysenterica leaf hydroalcoholic extract (EDE) (2.5-1000μg/mL) were carried out. Chromatographic analysis demonstrated presence tannin (ellagic acid) flavonoids (quercetin gallic which characterize EDE as polyphenol-rich mixture. Using HFF-1 fibroblasts, it was shown that promoted cell regeneration after UVA exposure. It also led to inhibition...
HDL particles are composed of an outer layer phospholipids and free cholesterol surrounding a hydrophobic core that consists primarily esters small amounts triglycerides (1). Apolipoprotein A-I (apo A-I) accounts for ∼60% the protein content HDL. Other apolipoprotein species found in include apo A-II, A-IV, CI, CIII, E. Several subfractions have been identified on basis density, electrophoretic mobility, particle size, composition (2). Differences size ascribed mainly to number molecules...
Carapa guianensis is a cultivable tree used by traditional health practitioners in the Amazon region to treat several diseases and particularly symptoms related malaria. Abundant residual pressed seed material (RPSM) results as by-product of carapa or andiroba oil production. The objective this study was evaluate vitro vivo anti-malarial activity cytotoxicity limonoids isolated from C. guaianensis RPSM. 6α-acetoxyepoxyazadiradione (1), andirobin (2), 6α-acetoxygedunin (3)...