A5011253365- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- Blood properties and coagulation
- Cancer-related molecular mechanisms research
- Intraocular Surgery and Lenses
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- Immune cells in cancer
- Digestive system and related health
- Aluminum toxicity and tolerance in plants and animals
- Hippo pathway signaling and YAP/TAZ
- Ocular Diseases and Behçet’s Syndrome
- Phagocytosis and Immune Regulation
- Ocular Disorders and Treatments
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- RNA regulation and disease
- Mast cells and histamine
- Chronic Lymphocytic Leukemia Research
University of Nebraska Medical Center
2022-2025
Pediatrics and Genetics
2025
Nebraska Medical Center
2024
Purpose of review This evaluates the known mechanisms regulating erythroid regeneration via sterile alpha motif protein-14 ( Samd14 ) enhancer, Samd14's role in stem cell factor/Kit and erythropoietin (Epo) signaling, possible SAMD14 functions beyond erythropoiesis, extrapolation to other anemia-response pathways. Recent findings expression is controlled by an anemia-activated E-box-GATA transcriptional enhancer required for regeneration, protein needed acute anemia recovery. interacts with...
Acute anemia elicits broad transcriptional changes in erythroid progenitors and precursors. We previously discovered a cis-regulatory enhancer at the sterile alpha motif domain-14 locus (S14E), defined by CANNTG-spacer-AGATAA composite occupied GATA1 TAL1 transcription factors, is required for survival severe anemia. However, S14E only 1 of dozens anemia-activated genes containing similar motifs. In mouse model acute anemia, we identified populations expanding precursors, which increased...
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals—involving cooperation between stem cell factor (SCF)/Kit signaling other inputs—are required for the increased precursor activity in anemia. Our prior work revealed that sterile alpha motif (SAM) domain 14 ( Samd14 ) gene increases regenerative capacity system a mouse genetic model promotes stress-dependent Kit signaling. However, mechanism underlying...
Abstract Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals – involving cooperation between SCF/c-Kit signaling other inputs are required for the increased precursor activity in anemia. Our prior work revealed that Sterile Alpha Motif (SAM) Domain 14 (Samd14) gene increases regenerative capacity system promotes stress-dependent c-Kit signaling. However, mechanism underlying Samd14’s role stress...