A5101828107- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Chronic Myeloid Leukemia Treatments
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Synthesis and biological activity
- Animal Virus Infections Studies
- Metal complexes synthesis and properties
- Alzheimer's disease research and treatments
- ECG Monitoring and Analysis
- Liver Disease and Transplantation
- Eosinophilic Disorders and Syndromes
- Phonocardiography and Auscultation Techniques
- Magnetic Properties and Synthesis of Ferrites
- Orthodontics and Dentofacial Orthopedics
- Hepatitis Viruses Studies and Epidemiology
- Dental Radiography and Imaging
- Malaria Research and Control
- Chaos-based Image/Signal Encryption
- Brain Tumor Detection and Classification
- Synthesis and Characterization of Heterocyclic Compounds
- Medical Image Segmentation Techniques
Chitkara University
2020-2025
Sawai ManSingh Medical College and Hospital
2013-2024
Indian Institute of Technology Bombay
2024
Punjab Agricultural University
2024
Christ University
2023
All India Institute of Medical Sciences Raipur
2022
Mahatma Gandhi Kashi Vidyapith
2022
Amity University
2021
Government of Himachal Pradesh
2020
Maimonides Medical Center
2018-2019
Background: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Data on the incidence of ACC, however, are scarce and not recent. The purpose this study was to characterize tumor patients developing ACC over last four decades using large population based database. Methods: We identified all cases diagnosed between 1973 - 2014 from Surveillance, Epidemiology, End Results-18 registry. Descriptive analyses were used for extracted demographic, clinical, pathological,...
Brain tumors are created by abnormal and uncontrolled cell division in brain itself.If the growth becomes more than 50%, then patient is not able to recover.So detection of tumor needs be fast accurate.The objective this paper provide an efficient algorithm for detecting edges tumor.The first step starts with acquisition MRI scan digital imaging techniques applied getting exact location size tumor.MRI images consist gray white matter region containing has intensity.So, noise filters used...
SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replication cycle could be potential therapeutic option counter growth the human body leading severe infectious stage. The Mpro SARS-CoV-2 promising target for development as it crucial transcription replication. derivatives β-diketone coumarin have...
Edge detection is a fundamental tool in image processing.Several edge detectors have been proposed literature for enhancing and detecting edges images.Image significantly reduces the amount of data filters out useless information, while preserving important structural properties an image.In this paper, application two-dimensional cellular automata using Moore Neighborhood has detection.The idea simple but effective technique detection.Edge basically occurs where there significant change...
Abstract Background Omicron a new variant of SARS COV2 was first detected in November 2021. This believed to be highly transmissible and evade immunity as result urgent need felt screen all positive, identify cases isolate them prevent spread infection study their clinico-epidemiological profile. Methodology All positive state Rajasthan during January beginning were selected for next generation sequencing. Processing done per protocol on Ion Torrent S5 system 1210 samples bioinformatics...
Omicron, a new variant of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), was first detected in November 2021. This believed to be highly transmissible and reported evade immunity. As result, an urgent need felt screen all positive samples so as rapidly identify Omicron cases isolate them prevent the spread infection. Genomic surveillance SARS-CoV-2 planned correlate disease severity with genomic profile.All state Rajasthan were sent our Lab. Samples received from 24 2021 4...
The present study looked at the correlation between mean trough Imatinib plasma levels and molecular response in 131 CML patients on imatinib. Patients receiving Glivec versus generic were also compared. A ROC curve was constructed to estimate a threshold level that correlates with favourable response. grouped into Responders (bcr/abl ration by RQ-PCR less than 1) Non (ration ≥ 1). imatinib responders significantly higher non (p = 0.001). area under 0.733, best sensitivity (51.85%)...
Room temperature hydrolysis of ammonia borane in presence electron beam irradiated Pd-C 3 N 4 catalyst.
Imatinib mesylate is currently the drug of choice for all phases chronic myeloid leukemia (CML). Despite initial high rates hematological and cytogenetic responses, many patients develop resistance. We prospectively studied 40 with CML primary resistance to imatinib mesylate. A semi-nested reverse transcriptase-PCR approach was used amplification ABL kinase domain, which then subjected direct sequencing detection point mutations. Expression BCR–ABL transcripts quantified using real-time...
Context: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan not well characterised. Aims: The present study was undertaken to identify and develop diagnostic algorithm so as help improved diagnosis, treatment, prevention control. Settings Design: hospital-based descriptive, observational study. Samples were processed at Grade-1 DHR/ICMR Viral Research Diagnostic Laboratory SMS, Jaipur....
First Zika virus (ZIKV) positive case from North India was detected on routine surveillance of Dengue-Like Illness in an 85-year old female. Objective the study to conduct investigation for epidemiological, clinical and genomic analysis first ZIKV outbreak Rajasthan, enhance surveillance. Outbreak performed 3 Km radius index among patient contacts, febrile cases, pregnant women. Routine enhanced include samples various districts Rajasthan. Presence serum urine by real time PCR test CDC...
Abstract The selective MAO‐B inhibition is greatly influenced by the degradation pathways of various biogenic amines. So design and development diverse class inhibitors are considered as an effective adjuvant therapy neurodegenerative disorders. Recent studies documented that introduction electron rich linker between two aryl or heteroaryl rings explored a promising structural framework MAO‐B. electrophilicity flexibility character can anchor different orientation binding mode in both...
Alzheimer's disease (AD) is the prime cause of 65-80% dementia cases and caused by plaque tangle deposition in brain neurons leading to cell degeneration. β-secretase (BACE-1) a key enzyme responsible for depositing extracellular plaques made β-amyloid protein. Therefore, efforts are being applied develop novel BACE-1 inhibitors halt build-up. In our study, we analyzed some Elenbecestat analogues (a inhibitor currently clinical trials) using structure-based drug design scaffold morphing...
Pandemic influenza A (H1N1) 2009 virus emerged in and caused pandemic with high morbidity mortality India worldwide. The number of H1N1-positive cases varied different years Rajasthan. objective the study was to present epidemiological profile Rajasthan from January March 2015.A retrospective descriptive, record-based analysis suspected confirmed infection Rajasthan, India, 2015 performed. Testing done as per Centers for Disease Control guidelines at nine laboratories approved by Government...
The proteolytic enzymesinvolved in the processing and replication of coronavirus serve a promising drug targetsfor coronavirus. Although few numbers vaccines have been made available, there is great need for effective treatment to manageit. current study involved exploration baicalin analogues as potential inhibitor viral enzyme. Utilizing various computational tools (scaffold morphing, molecular docking pharmacokinetic studies), B74 B86 analogueswere screened inhibitors main protease....