A5068352055- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Porphyrin and Phthalocyanine Chemistry
- Carbohydrate Chemistry and Synthesis
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- Asymmetric Synthesis and Catalysis
- Advanced biosensing and bioanalysis techniques
- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- DNA and Nucleic Acid Chemistry
- Photodynamic Therapy Research Studies
- Chemical Synthesis and Analysis
- Metal-Catalyzed Oxygenation Mechanisms
- Fluorine in Organic Chemistry
- Glycosylation and Glycoproteins Research
- Chemical Reaction Mechanisms
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Synthesis and Biological Evaluation
- Ferrocene Chemistry and Applications
- Magnetism in coordination complexes
Nara Women's University
2016-2025
Nara University of Education
2009-2021
Sun Yat-sen University
2021
Université Laval
2021
Justus-Liebig-Universität Gießen
2021
Rutgers, The State University of New Jersey
2021
Kunming University of Science and Technology
2021
Wuyi University
2021
Zhengzhou University
2021
Slovak University of Technology in Bratislava
2021
We report herein the synthesis of an unprecedented isomer perylene, dicyclohepta[cd,fg]‐as‐indacene bearing two phenyl groups (1‐Ph) by nickel‐mediated intramolecular homocoupling a 4,4'‐biazulene derivative (2). The X‐ray crystallographic analysis and theoretical calculations revealed that 1‐Ph adopts unique helically twisted geometry although local aromaticity azulene moieties was preserved. double covalent linkage skeletons imparts significant orbital interaction, which affords...
Novel chelators, i.e., 4-(2-pyridyl)-1,2,3-triazole derivatives, were synthesized by means of Cu(I)-catalyzed 1,3-dipolar cycloaddition and used to prepare luminescent Re(I) complexes [ReCl(CO)3(Bn-pyta)], [ReCl(CO)3(AcGlc-pyta)] [ReCl(CO)3(Glc-pyta)] (Bn-pyta = 1-benzyl-4-(2-pyridyl)-1,2,3-triazole, AcGlc-pyta 2-(4-(2-pyridyl)-1,2,3-triazol-1-yl)ethyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside, Glc-pyta β-D-glucopyranoside). X-Ray crystallography Bn-pyta indicated an azocompound-like...
Two methoxy-substituted TQEN (N,N,N',N'-tetrakis(2-quinolylmethyl)ethylenediamine) derivatives, T(MQ)EN (N,N,N',N'-tetrakis(6-methoxy-2-quinolylmethyl)ethylenediamine) and T(TMQ)EN (N,N,N',N'-tetrakis(5,6,7-trimethoxy-2-quinolylmethyl)ethylenediamine), have been prepared, their fluorescence properties with respect to Zn2+ coordination were investigated. Introduction of a methoxy substituent at 6-position the quinoline ring enhances intensity by 10-fold, three substituents in 5,6,7-positions...
A new fluorescent sensor for zinc that binds 1 equivalent of ion, N,N,N',N'-tetrakis(2-quinolylmethyl)ethylenediamine (TQEN), has been prepared and characterized. Zinc-bound TQEN exhibits fluorescence around 383 nm upon excitation at 317 nm, while free emits very weak fluorescence. UV-Vis 1H NMR spectral changes also detected the binding with ion. The crystal structure complex was determined by X-ray crystallography compared TPEN-Zn (TPEN =N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine)....
The hexadentate nitrogen ligands 1-isoTQEN (N,N,N',N'-tetrakis(1-isoquinolylmethyl)ethylenediamine) and 3-isoTQEN (N,N,N',N'-tetrakis(3-isoquinolylmethyl)ethylenediamine) have been prepared. structures of these are based on that TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine). introduction a benzene ring into affords fluorescence ability upon zinc-ion binding. Compared to the quinoline isomer TQEN, isoquinoline derivatives exhibit lower-energy shift in excitation emission...
Two cyclohexanediamine-based tetrakisquinoline derivatives, N,N,N′,N′-tetrakis(2-quinolylmethyl)-trans-1,2-cyclohexanediamine (TQDACH) and N,N,N′,N′-tetrakis(1-isoquinolylmethyl)-trans-1,2-cyclohexanediamine (1-isoTQDACH), have been prepared their zinc-induced fluorescent response was investigated. In DMF–H2O (1 : 1) solution, TQDACH exhibits increase of fluorescence at 455 nm in the presence 1 eq. zinc ion (λex = 317 nm, ϕ 0.010). Similarly, 1-isoTQDACH exhibited enhancement upon binding...
Three discrete carbohydrate-appended 2,2'-dipicolylamine ligands were complexed to the {M(CO)(3)}(+) (M = (99m)Tc/Re) core: 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-d-glucopyranoside (L(1)()), 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-D-xylopyranoside (L(2)()), and 2-(bis(2-pyridinylmethyl)amino)ethyl-alpha-d-mannopyranoside (L(3)). An ethylene spacer is used separate carbohydrate moiety dipicolylamine (DPA) function in all three ligands. The Re complexes [Re(L(1-3))(CO)(3)]Br characterized...
Several bisquinoline derivatives, N,N′-bis(2-quinolylmethyl)-N,N′-dialkylethylnediamines (alkyl = methyl, ethyl, isopropyl and t-butyl), have been synthesized their fluorescent responses toward zinc ion were investigated. These compounds exhibit ion-induced fluorescence intensities decrease as the alkyl groups become larger. The t-butyl derivative (BQDtBEN) exhibited negligible even in presence of ion. intensity complex (BQDMEN) is higher than that TQEN...
Isoquinoline-based tetradentate ligands with C3-symmetry, tris(1- or 3-isoquinolylmethyl)amine (1- 3-isoTQA), have been prepared and their zinc-induced fluorescence enhancement was investigated. Upon excitation at 324 nm, 1-isoTQA shows very weak (ϕ = ∼0.003) in DMF/H2O (1/1) solution. In the presence of zinc ion, exhibits increase 0.041) 359 470 nm. This nm is specific for zinc. However, 3-isoTQA exhibited a smaller upon complexation 0.017, λem 360 464 nm) compared 1-isoTQA. Crystal...
The synthesis and metal complexation of a glucosamine-appended 2,2′-dipicolylamine ligand to the tricarbonyls 99mTc 186Re is described; was found bind in tridentate fashion with glucosamine function remaining pendant, complex exhibit exceptional stability towards vitro exchange experiments.
Abstract Seven discrete sugar‐pendant diamines were complexed to the {M(CO) 3 } + ( 99m Tc/Re) core: 1,3‐diamino‐2‐propyl β‐ D ‐glucopyranoside L 1 ), ‐xylopyranoside 2 α‐ ‐mannopyranoside ‐galactopyranoside 4 5 β‐(α‐ ‐glucopyranosyl‐(1,4)‐ ‐glucopyranoside) 6 and bis(aminomethyl)bis[(β‐ ‐glucopyranosyloxy)methyl]methane 7 ). The Re complexes [Re( – )(Br)(CO) ] characterized by H 13 C 1D/2D NMR spectroscopy which confirmed pendant nature of carbohydrate moieties in solution. Additional...
Tris(2-pyridylmethyl)amine-based fluorescent ligands, N,N-bis(1-isoquinolylmethyl)-2-pyridylmethylamine (1-isoBQPA) and N,N-bis(7-methoxy-1-isoquinolylmethyl)-2-pyridylmethylamine (7-MeO-1-isoBQPA), have been prepared the Zn2+-induced fluorescence enhancement has investigated. Upon excitation at 324 nm, 1-isoBQPA exhibits a very weak emission (ϕ = ∼0.010) in DMF–H2O (1 : 1). Zn2+ addition, increases (ϕZn 0.055) 357 nm 464 nm. The longer wavelengths is Zn2+-specific, whereas Cd2+ induces...
BQDMEN (N,N'-bis(2-quinolylmethyl)-N,N'-dimethylethylenediamine) and its 6-methoxyquinoline derivative (6-MeOBQDMEN) are fluorescent Zn2+ sensors with minor response to Cd2+ (IZn/ICd = 3.9 for IZn/ICd 2.2 6-MeOBQDMEN in the presence of 1 equiv. metal ion). Nevertheless, introduction three methoxy substituents at 5,6,7-position both quinoline rings reversed ion selectivity favor 0.22 TriMeOBQDMEN This reversal Zn2+/Cd2+ preference fluorescence enhancement by trimethoxy substitution was also...
Abstract Four platinum(II) and palladium(II) complexes with sugar‐conjugated bipyridine‐type triazole ligands, [Pt II Cl 2 (AcGlc‐pyta)] ( 3 ), [Pd 4 (Glc‐pyta)] 5 6 were prepared characterized by mass spectrometry, elemental analysis, 1 H‐ 13 C‐NMR, IR as well UV/VIS spectroscopy, where AcGlc‐pyta Glc‐pyta denote 2‐[4‐(pyridin‐2‐yl)‐1 H ‐1,2,3‐triazol‐1‐yl]ethyl 2,3,4,6‐tetra‐ O ‐acetyl‐ β ‐ D ‐glucopyranoside ) respectively. The solid‐state structure of complex was determined...
Dinuclear zinc complex [Zn2(TQHPN)(AcO)](2+) exhibits characteristic fluorescence response (λex = 317 nm and λem 455 nm) toward pyrophosphate (PPi) with maximum upon 1:1 Zn2(TQHPN)-PPi formation. The crystallographic investigation utilizing P(1)P(2)-Ph2PPi revealed that the fluorescent mechanism is due to intramolecular excimer formation of two quinoline rings.
TACN (1,4,7-triazacyclononane) derivatives with three 6-methoxy-2-quinolylmethyl or 1-isoquinolylmethyl moieties were examined as fluorescent zinc sensors. Upon the addition of zinc, 6-MeOTQTACN (5) exhibited a 9-fold fluorescence increase at 420 nm (λex = 341 nm, ϕZn 0.070). Fluorescence enhancement is specific for and cadmium, although cadmium induces smaller increases (ICd/I0 3.6 ICd/IZn 40%). The isoquinoline analog 1-isoTQTACN (6) exhibits minimal upon binding. TPEN...
Indenes are important core structures in organic chemistry. Few simple arylallenes have been used to construct indene skeletons by Friedel−Crafts reaction. Lewis acid catalyzed reaction of ethenetricarboxylates 1 and has examined this study. The ethenetricarboxylate triesters with SnCl4 gave derivatives efficiently, via a conjugate addition/Friedel−Crafts cyclization On the other hand, reactions 1,1-diethyl 2-hydrogen or alkylallenes at −78 °C room temperature subsequent treatment Et3N...