A5101836923- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Ubiquitin and proteasome pathways
- Mast cells and histamine
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Muscle Physiology and Disorders
- Biochemical and Molecular Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Telomeres, Telomerase, and Senescence
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Respiratory Support and Mechanisms
- Vitamin K Research Studies
- Lung Cancer Treatments and Mutations
Takeda (United States)
2019-2022
The University of Texas Southwestern Medical Center
2020-2021
Southwestern Medical Center
2020-2021
Sun Yat-sen Memorial Hospital
2021
Sun Yat-sen University
2021
Hospital Alemán
2019
Affiliated Hospital of Guizhou Medical University
2018
Shenzhen Luohu People's Hospital
2014
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease in which the dystrophin coding for a membrane stabilizing protein mutated. Recently, vasculature has also shown to be perturbed DMD and model mdx mice. Recent transcriptomics revealed defects were correlated vascular endothelial growth factor (VEGF) signaling pathway. To reveal relationship between VEGF signaling, mice crossed with constitutive (CAGCreERTM:Flt1LoxP/LoxP) cell-specific conditional gene knockout...
Activated leukocyte cell adhesion molecule (ALCAM) has been identified as a novel potential molecular marker of human tumors. The present study aimed to assess ALCAM prognostic for gastric cancer (GC), and explore the mRNA deregulation underlying abnormal expression ALCAM. protein in GC adjacent non‑tumor tissues from 66 patients with were analyzed. association between miR‑9 was determined by quantitative polymerase chain reaction. Serum soluble (sALCAM) analyzed ELISA 72 GC, 82 precancerous...
Hereditary angioedema (HAE) is a rare genetic disease caused by deficiency or dysfunction of C1 esterase inhibitor (C1-INH). Plasma C1-INH activity and concentrations complement components 1q 4 (C1q, C4) are critical to the HAE diagnosis. We describe novel multiplexed assay simultaneously measure C1-INH, C1q, C4 levels in dried blood spot (DBS) patients. The proteins were extracted from 3 mm punches DBS samples subsequently digested trypsin. signature peptide derived each protein was...
Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which exacerbated localized functional ischemia due to loss nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing vascular perfusion have been proposed. Toward this end, we developed monoclonal antibodies (mAbs) that bind the endothelial growth factor (VEGF) receptor VEGFR-1 (Flt-1) and its soluble splice variant isoform (sFlt-1) leading increased levels free VEGF proangiogenic...
Lung cancer is the most aggressive cancer, resulting in one-quarter of all cancer-related deaths, and its metastatic spread accounts for >70% these especially metastasis to brain. Metastasis-associated mutations are important biomarkers prediction outcome improvement.In this study, we applied whole-exome sequencing (WES) identify potential metastasis-related 12 paired lung brain samples.We identified 1,702 single nucleotide variants (SNVs) 6,131 mutation events among 1,220 genes....
Beta-catenin serves not only as a structural component of the E-cadherin-mediated cell-cell adhesion system, but also signaling molecule Wnt/wingless pathway. Mutations beta-catenin and aberrant expression its protein have been identified in number different types human malignancies. To determine role solid cystic tumor (SCT) pancreas, rare neoplasm usually observed young females, we examined three primary tumors one corresponding liver metastatic presented pediatric patients. Single strand...
Objective: We validated three methods for measuring Functional C1-Esterase Inhibitor (fC1-INH) in K3EDTA human plasma Shire clinical studies: conventional chromogenic assay residual C1-esterase activity, Complement C1s component (C1s) binding based Electrochemiluminescent (ECL) assay, and Factor XIIa (FXIIa) Enzyme linked immunosorbent (ELISA).We performed a side-by-side comparison of all with consented pharmacodynamic (PD) samples from the SAHARA Phase 3, randomized, double-blind,...
Abstract Background: Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and overexpressed cancer. However, biological role mechanism of APE1 rarely been studied. Methods: We used gene set enrichment analysis (GSEA) to determine APE1-related signaling pathways To investigate metastasis, invasion, immunohistochemistry, immunofluorescence, western...
Abstract RAS proteins are guanosine triphosphatases (GTPases) that function as binary switches cycling between inactive (GDP-bound) and active (GTP-bound) states. Activated bind effectors including RAF kinases, PI3K, RalGDS, others. Conversion from GDP to GTP is stimulated by guanine nucleotide exchange factors (GEFs) while conversion the GDP-bound form mediated GTPase activating (GAPs). Mutations can alter signaling properties of through a number means modification activity, rate, or...
Objective To investigate the effects of Danusertib on changes in Aurora kinase B (Aurora B)/ ribosomal protein p70S6 (p70S6K)/ribosomal 15 (RPL15) signaling pathway and autophagy human leukemia cells its mechanism. Methods Myeloid cell lines THP-1 K562 were selected as research subjects.The experiment was divided into 2 phases.Phase 1: each line treated with concentration 0.1 μmol/L, 1.0 μmol/L 5.0 μmol/L.In control group, mL/L dimethyl sulfoxide (DMSO) given.All cultured for 24...