A5038977222- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Spinal Cord Injury Research
- Motor Control and Adaptation
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Cell Image Analysis Techniques
- Advanced Memory and Neural Computing
- Health, Environment, Cognitive Aging
- Advanced Sensor and Energy Harvesting Materials
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Fish biology, ecology, and behavior
- Nerve Injury and Rehabilitation
- Neuroscience, Education and Cognitive Function
- Vagus Nerve Stimulation Research
- Tactile and Sensory Interactions
- Underwater Vehicles and Communication Systems
- Zebrafish Biomedical Research Applications
Foundation for Research on Information Technologies in Society
2021-2025
University of Fribourg
2019-2022
Duke University
2011-2021
École Polytechnique Fédérale de Lausanne
2017-2019
ABSTRACT Temporal interference stimulation (TIS) is a new form of transcranial electrical (tES) that has been proposed as method for targeted, noninvasive deep brain structures. While TIS holds promise variety clinical and nonclinical applications, little data yet available regarding its effects in humans mechanisms action. To inform the design safe conduct experiments involving TIS, researchers require quantitative guidance exposure limits other safety considerations. this end, we undertook...
The weakly electric glass knifefish, Eigenmannia virescens, will swim forward and backward, using propulsion from an anal ribbon fin, in response to motion of a computer-controlled moving refuge. Fish were recorded performing refuge-tracking behavior for sinusoidal (predictable) sum-of-sines (pseudo-random) refuge trajectories. For all trials, we observed high coherence between fish trajectories, suggesting linearity the tracking dynamics. But superposition failed: categorical differences...
The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds provide...
Traditionally, brain-machine interfaces (BMIs) extract motor commands from a single brain to control the movements of artificial devices. Here, we introduce Brainet that utilizes very-large-scale activity (VLSBA) two (B2) or three (B3) nonhuman primates engage in common behaviour. A B2 generated 2D an avatar arm where each monkey contributed equally X and Y coordinates; one fully controlled X-coordinate other Y-coordinate. B3 produced 3D space, while subspaces (X-Y, Y-Z, X-Z). With long-term...
Recent advances in the field of brain-machine interfaces (BMIs) have demonstrated enormous potential to shape future rehabilitation and prosthetic devices. Here, a lower-limb exoskeleton controlled by intracortical activity an awake behaving rhesus macaque is presented as proof-of-concept for locomotorBMI. A detailed description mechanical device, including its innovative features first experimental results, provided. During operation, BMI-decoded position velocity are directly mapped onto...
Abstract Temporal interference stimulation (TIS) is a new form of transcranial electrical (tES) that has been proposed as method for targeted, non-invasive deep brain structures. While TIS holds promise variety clinical and non-clinical applications, little data yet available regarding its effects in humans. To inform the design approval experiments involving TIS, researchers require quantitative guidance exposure limits other safety concerns. this end, we sought to delineate safe range...
Proprioceptive feedback is a critical component of voluntary movement planning and execution. Neuroprosthetic technologies aiming at restoring must interact with it to restore accurate motor control. Optimization design such depends on the availability quantitative insights into neural dynamics proprioceptive afferents during functional movements. However, recording activity unconstrained movements in clinically relevant animal models presents formidable challenges. In this work, we...
Correlation between cortical activity and electromyographic (EMG) of limb muscles has long been a subject neurophysiological studies, especially in terms corticospinal connectivity. Interest this issue recently increased due to the development brain-machine interfaces with output signals that mimic muscle force. For study, three monkeys were implanted multielectrode arrays multiple areas. One monkey performed self-timed touch pad presses, whereas other two executed arm reaching movements. We...
ABSTRACT The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds...
Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains large societal burden. Neurophysiological neuroprosthetic research have the potential to improve quality of life these patients; however, lack an ethical sustainable nonhuman primate model paraplegia hinders their advancement. Therefore, our multidisciplinary team developed way induce temporary in awake behaving macaques by creating fully implantable lumbar epidural...
In order to advance the field of neuroscience, we must continue motivating youth pursue science education. this report tested idea combining neurogaming with We developed a pair electroencephalography (EEG)-controlled neurogames using inexpensive and/or free tools teach students about fundamentals neuroscience and brain machine interfaces (BMI) through fun, interactive activity. on particular concepts they allowed us introduce, techniques methods used, effect activities stimulating students’...
Abstract Proprioceptive feedback is a critical component of voluntary movement planning and execution. Neuroprosthetic technologies aiming at restoring must interact with it to restore accurate motor control. Optimization design such depends on the availability quantitative insights into neural dynamics proprioceptive afferents during functional movements. However, recording activity unconstrained movements in clinically relevant animal models presents formidable challenges. In this work, we...
Abstract Recovering arm control is a top priority for people with paralysis. Unfortunately, the complexity of neural mechanisms underlying practically limited effectiveness neurotechnology approaches. Here, we exploited function surviving spinal circuits to restore voluntary and hand in three monkeys cord injury using stimulation. Our interface leverages functional organization dorsal roots convey artificial excitation via electrical stimulation relevant segments at appropriate movement...
The NIH SPARC initiative aims to “transform the understanding of nerve‐organ interactions” and “advance neuromodulation field towards precise disease treatment.” To this end, a freely‐accessible online platform (o 2 S PARC) has been designed complement leverage in vitro vivo physiological experiments with computational modeling. Computational models validated on existing data, can be used investigate manifold subjects including organ electrophysiology, neural dynamics electroceutical device...
There is a growing trend within the neuroscience community and medical health industries towards bioelectronics medicine: applying electrical signals to nervous system control modulate functions of body. These so‐called “electroceuticals” include numerous types neurostimulation devices. To this end, we have developed reference animal human anatomical models with unprecedented details in peripheral system, connectivity organs muscles, which were functionalized compartmental neuronal dynamics...
Abstract Regaining arm motor control is critical for people with paralysis. Despite promising results on grasping, no technology could restore effective control. Here, we show that electrical stimulation of the cervical spinal cord enabled three monkeys injury to execute functional movements. We designed an epidural interface engaged surviving circuits via recruitment large sensory afferents produce movement. Simple bursts produced sustained joint movements which, triggered by...