A5021119754- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Transcranial Magnetic Stimulation Studies
- Vagus Nerve Stimulation Research
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- NMR spectroscopy and applications
- Spinal Cord Injury Research
- Sleep and Wakefulness Research
- Electromagnetic Fields and Biological Effects
- Wireless Body Area Networks
- Electrical and Bioimpedance Tomography
- Pain Management and Treatment
- Anatomy and Medical Technology
- Advanced NMR Techniques and Applications
- Stroke Rehabilitation and Recovery
- Advanced Memory and Neural Computing
- Ultrasound and Hyperthermia Applications
- Obstructive Sleep Apnea Research
Foundation for Research on Information Technologies in Society
2016-2025
University of Padua
2024
Universidade Sénior Contemporânea
2018
Universidade do Porto
2018
Physikalisch-Technische Bundesanstalt
2014-2016
Enrico Fermi Center for Study and Research
2008-2012
Sapienza University of Rome
2007-2011
Fondazione Santa Lucia
2011
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields frequencies too high recruit neural firing, but which differ by frequency within dynamic range of we can stimulate throughout region where interference between results in prominent field envelope modulated difference frequency. validated this temporal (TI) concept via modeling and physics experiments, verified that living mouse could follow envelope. demonstrate...
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use deployment in research. Temporal interference (TI) a strategy for non-invasive steerable DBS using multiple kHz-range electric fields difference frequency within the range of neural activity. Here we report validation concept humans. We field modeling measurements human cadaver verify that...
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference (tTIS) is a novel, noninvasive technology that might overcome this limitation. initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful neuromodulation the striatum via tTIS in humans using computational functional magnetic resonance imaging studies behavioral evaluations. Theta-burst...
ABSTRACT Temporal interference stimulation (TIS) is a new form of transcranial electrical (tES) that has been proposed as method for targeted, noninvasive deep brain structures. While TIS holds promise variety clinical and nonclinical applications, little data yet available regarding its effects in humans mechanisms action. To inform the design safe conduct experiments involving TIS, researchers require quantitative guidance exposure limits other safety considerations. this end, we undertook...
Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates characteristic Gibbs distortion. We then used ecHT show aberrant oscillation hallmarks essential tremor (ET) syndrome, most common adult movement disorder, can be transiently suppressed transcranial electrical stimulation cerebellum phase-locked tremor. The suppression is sustained shortly after end...
Neurostimulation applied from deep brain stimulation (DBS) electrodes is an effective therapeutic intervention in patients suffering intractable drug-resistant epilepsy when resective surgery contraindicated or failed. Inhibitory DBS to suppress seizures and associated epileptogenic biomarkers could be performed with high-frequency (HFS), typically between 100 165 Hz, various deep-seated targets, such as the Mesio-temporal lobe (MTL), which leads changes rhythms, specifically hippocampus....
Abstract Background Peripheral nerve stimulation is used in both clinical and fundamental research for therapy exploration. At present, non-invasive peripheral still lacks the penetration depth to reach deep targets focality offer selectivity. It therefore rarely employed as primary selected method. We have previously demonstrated that a new technique, temporal interference stimulation, can overcome issues. Methods Here, we implement novel form of interference, bilateral hypoglossal rodents...
The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, simulation tools for mammalian autonomic nervous system. experimental data mathematical models supplied to DRC by consortium are curated, annotated semantically linked via a single knowledgebase. A portal has been developed that allows discovery both semantic search an interface includes Google Map-like 2D flatmaps displaying connectivity, 3D anatomical organ scaffolds provide...
Abstract Electrical stimulation of peripheral nerves is a cornerstone bioelectronic medicine. Effective ways to accomplish nerve (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it demonstrated how relatively high‐frequency sine‐wave carriers (3 kHz) emitted by two pairs cutaneous electrodes can temporally interfere at deep targets. The effective frequency equal the offset (0.5 – 4 Hz) between carriers. This...
Abstract Temporal Interference (TI) is an emerging method to non-invasively stimulate deep brain structures. This innovative technique increasingly recognized for its potential applications in the treatment of various neurological disorders, including epilepsy, depression, and Alzheimer’s disease. However, several drawbacks TI exist that we aim improve upon. To begin, applied electric field target not much higher than what non-invasive transcranial alternating current stimulation (TACS)...
Abstract As the size and complexity of network simulations accessible to computational neuroscience grows, new avenues open for research into extracellularly recorded electric signals. Biophysically detailed permit identification biological origins different components signals, evaluation signal sensitivity anatomical, physiological, geometric factors, selection recording parameters maximize information content. Simultaneously, virtual extracellular signals produced by these networks may...
Abstract Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular disease. We hypothesized that stimulation paradigm using temporal interference (TI) could restore breathing in such conditions. Following opioid rats, two high frequency (5000 Hz and 5001 Hz), low amplitude waveforms delivered via intramuscular wires the neck immediately activated diaphragm restored ventilation phase with waveform offset (1 60 breaths/min). cervical spinal cord injury (SCI),...
ABSTRACT Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders however its invasiveness precludes widespread clinical use deployment in research. Temporal interference (TI) a strategy for non-invasive steerable DBS using multiple kHz-range electric fields difference frequency within the range of neural activity. Here we report validation concept humans. We field modelling measurements human cadaver verify...
Abstract Objective: Non-invasive brain stimulation (NIBS) offers therapeutic benefits for various disorders. Personalization may enhance these by optimizing parameters individual subjects. Approach: We present a computational pipeline simulating and assessing the effects of NIBS using personalized, large-scale network activity models. Using structural MRI diffusion-weighted imaging data, leverages convolutional neural network-based segmentation algorithm to generate subject-specific head...
Abstract Background Temporal interference stimulation (TIS) is a novel noninvasive electrical technique to focally modulate deep brain regions; minimum of two high‐frequency signals ( f 1 and 2 > kHz) interfere create an envelope‐modulated signal at target with the frequency modulation equal difference frequency: Δ = | – |. Objective The goals this study were verify capability TIS subthalamic nucleus (STN) compare effect conventional (DBS) on STN beta oscillations in patients Parkinson's...