A5014663996- Vagus Nerve Stimulation Research
- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Angiogenesis and VEGF in Cancer
- Biomarkers in Disease Mechanisms
- Adenosine and Purinergic Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle activation and electromyography studies
- Intensive Care Unit Cognitive Disorders
- Neuroscience of respiration and sleep
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
Karolinska University Hospital
2019-2023
Karolinska Institutet
2019-2023
Significance Resolution of inflammation is an active process that restores tissue homeostasis and prevents the development chronic inflammatory diseases. The mechanisms regulate resolution are only partially understood. Here, we showed activation vagus nerve accelerated inflammation. Electrical stimulation in vivo increased levels select specialized proresolving mediators Experiments genetic mouse models revealed mechanism involved 12/15-lipoxgenase (Alox15), a key enzyme for biosynthesis...
Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces in models inflammatory disease. These discoveries have generated an increasing interest targeted neurostimulation as treatment for chronic diseases. Data from first clinical trials that use stimulation (VNS) rheumatoid arthritis Crohn's disease suggest there is a therapeutic potential VNS diseases characterized by excessive inflammation. Accordingly, to further explore molecular mechanisms range...
Abstract Electrical stimulation of peripheral nerves is a cornerstone bioelectronic medicine. Effective ways to accomplish nerve (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it demonstrated how relatively high‐frequency sine‐wave carriers (3 kHz) emitted by two pairs cutaneous electrodes can temporally interfere at deep targets. The effective frequency equal the offset (0.5 – 4 Hz) between carriers. This...
Endothelial dysfunction and impaired vasodilation are linked with adverse cardiovascular events. T lymphocytes expressing choline acetyltransferase (ChAT), the enzyme catalyzing biosynthesis of vasorelaxant acetylcholine (ACh), regulate integral to cholinergic antiinflammatory pathway in an inflammatory reflex mice. Here, we found that human cell ChAT mRNA expression was induced by activation involving PI3K signaling cascade. Mechanistically, identified following attenuation RE-1 Silencing...
Radiotherapy-induced cardiovascular disease is an emerging problem in a growing population of cancer survivors where traditional treatments, such as anti-platelet and lipid-lowering drugs, have limited benefits. The aim the study was to investigate vascular inflammatory patterns human survivors, replicate findings animal model, evaluate whether interleukin-1 (IL-1) inhibition could be potential treatment.Irradiated arterial biopsies were collected during microvascular autologous free tissue...
Chronic inflammation is a hallmark of atherosclerosis and results from an imbalance between proinflammatory proresolving signaling. The human GPR32 receptor, together with the ALX/FPR2 transduces biological actions several mediators that stimulate resolution inflammation. However, since no murine homologs receptor exist, comprehensive in vivo studies are lacking. Using atherosclerotic lesions carotid endarterectomies creating transgenic mouse model expressing on Fpr2×ApoE double-KO...
Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries atherosclerotic plaques. They have an ability to adapt changes in the local environment by undergoing phenotypic modulation. An improved understanding mechanisms that regulate VSMC may provide insights suggest new therapeutic targets treatment cardiovascular disease (CVD). The amino-acid glutamate has been associated with CVD risk VSMCs metabolism experimental models, receptors biology...
Abstract Background The interplay between innate and adaptive immunity is central in life‐threatening clinical complications of atherosclerosis such as myocardial infarction stroke. specific mechanisms involved their protective versus detrimental effects the disease process remain poorly understood. We have previously shown that higher levels Toll‐like receptor 7 (TLR7) expression human atherosclerotic lesions are correlated with better patient outcome. Objective In this study, we explored...
Physical impairment after critical illness is recognized as a part of the post-intensive care syndrome (PICS). About one third intensive unit (ICU) survivors suffer from long-term physical disability, yet underlying pathophysiological mechanisms remain poorly understood. The pro-inflammatory alarmin, high mobility group box 1 (HMGB1), promotes muscle dysfunction in experimental models, and HMGB1 stays elevated some patients ICU discharge. Accordingly, we investigated relationship between...
Abstract Electrical stimulation of peripheral nerves is a cornerstone bioelectronic medicine. Effective ways to accomplish nerve noninvasively without surgically implanted devices enabling for fundamental research and clinical translation. Here we demonstrate how relatively high frequency sine-wave carriers (3 kHz) emitted by two pairs cutaneous electrodes can temporally interfere at deep targets. The effective equal the offset (0.5 – 4 Hz) between carriers. We validate this principle...
Abstract Background The interplay between innate and adaptive immunity is involved in the cause of life-threatening events atherosclerosis, such as myocardial infarction stroke. We have previously shown that higher levels Toll-like receptor 7 (TLR7) expression human atherosclerotic lesions are correlated to better patient outcome, emphasizing role pattern recognizing receptors pathogenesis atherosclerosis. Purpose Firstly, investigate if activation immune TLR7 vivo experimental...