A5102012879- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Natural Products and Biological Research
- Cytokine Signaling Pathways and Interactions
- Cardiac Health and Mental Health
- Antioxidant Activity and Oxidative Stress
- Immune Response and Inflammation
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- S100 Proteins and Annexins
- Heart Rate Variability and Autonomic Control
- Neuropeptides and Animal Physiology
- Estrogen and related hormone effects
Karolinska Institutet
2015-2021
Karolinska University Hospital
2015-2016
In addition to enhanced proinflammatory signaling, impaired resolution of vascular inflammation plays a key role in atherosclerosis. Proresolving lipid mediators formed through the 12/15 lipoxygenase pathways exert protective effects against murine n-3 Polyunsaturated fatty acids, including eicosapentaenoic acid (EPA), serve as substrate for formation mediators, which transduce potent anti-inflammatory and proresolving actions their cognate G-protein-coupled receptors. The aim this study was...
Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4 (LTB4) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates resolution of The aim this study was to determine association RvD1/LTB4 ratio with subclinical atherosclerosis. Saliva samples and ultrasound measurements intima media thickness carotid artery obtained for 254 participants. RvD1 LTB4 were measured...
Aortic valve stenosis (AVS), which is the most common valvular heart disease, causes a progressive narrowing of aortic as consequence thickening and calcification leaflets. The beneficial effects omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular prevention have recently been demonstrated large randomized, controlled trial. In addition, n-3 PUFAs serve substrate for synthesis specialized proresolving mediators, are known by their potent anti-inflammatory, proresolving,...
An abdominal aortic aneurysm (AAA) is a progressive dilation that may lead to rupture, which usually lethal. This study identifies the state of failure in resolution inflammation by means decreased expression pro-resolving receptor A lipoxin/formyl peptide 2 (ALX/FPR2) adventitia human AAA lesions. Mimicking this condition genetic deletion murine ALX/FPR2 ortholog hyperlipidemic mice exacerbated induced angiotensin II infusion, associated with vascular collagen and increased inflammation....
Chronic inflammation is a hallmark of atherosclerosis and results from an imbalance between proinflammatory proresolving signaling. The human GPR32 receptor, together with the ALX/FPR2 transduces biological actions several mediators that stimulate resolution inflammation. However, since no murine homologs receptor exist, comprehensive in vivo studies are lacking. Using atherosclerotic lesions carotid endarterectomies creating transgenic mouse model expressing on Fpr2×ApoE double-KO...
Salivary biomarkers may offer a noninvasive and easy sampling alternative in cardiovascular risk evaluation. The aim of the present study was to establish associations salivary potassium, sodium, calcium, phosphate levels with phenotype determined by carotid ultrasound carotid-femoral pulse wave velocity identify possible covariates for these associations. <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn>241</mml:mn></mml:math>...