Background Frailty is associated with aging, but it more prominent among the patients on dialysis and characterized by increased vulnerability to stressors, which adverse outcomes poor quality of life. The aim this study evaluate association neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), frailty in hemodialysis effect their outcomes. Patients methods A cross-sectional was conducted 80 patients, divided into two groups according Till Burg indicator. Sociodemographic data,...

Increasing interest has been focused on lncRNAs as potential markers in the pathogenesis and progression of numerous diseases.We aimed to investigate expression pattern role cell-free (GAS5, HCG27_201 LY86-AS1) pre-diabetic, diabetic T2DM groups.Quantification level was performed by real-time PCR 210 individuals classified (T2DM), pre-diabetic control groups.Significant differences were observed relative LY86-AS1 HCG27_201) among three studied groups. The LncRNA levels decreased gradually...

Background: Circular RNAs are a type of closed non-coding RNAs, lack the terminating 5'-capand 3'-polyadenylated tail structures that present in linear RNAs. They have higher biologicalstability because their resistance to RNA exonucleases and some tissues; expressionlevels ten times than other types RNA. CircRNAs act as biomarkers for variousdiseases including diabetes mellitus they been found affect insulin secretion β-cellrenewal. Objective: investigate role circRNA (0054633) biomarker...

BACKGROUND Acute kidney injury (AKI) is a common complication in hospitalized patients. Several risk score models have been designed for intensive care unit (ICU) We aim to establish new prediction AKI patients general wards. MATERIALS AND METHODS All ward who developed were included our study. To develop model we used the data collected from 107 AKI. prospective validation cohort (122 patients) and validate this of RESULTS Of 10,243 patients, (1%) 24 hours after admission Mortality rate was...

Objective: The aim of the work is to study relationship between Red blood cell osmotic fragility and level parathyroid hormone in patients with different stages Chronic Kidney Disease including End Stage Renal Disease. Background: Anaemia one common complications associated (CKD) responsible for increase morbidity mortality such patients. Several factors have been attributed causing renal anaemia, amongst which hyperparathyroidism less recognised reasons. PTH early chronic kidney disease has...

Abstract Background NAFLD is a spectrum of disorders ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), NASH related cirrhosis and hepatocellular carcinoma (HCC). There sparse data on the prevalence CKD in Egyptian patients with NAFLD. The aim this study estimate subjects assess risk factors among them. Methods A cross-sectional was conducted 430 Internal Medicine Department, Menoufia University Hospitals, including 215 NAFLD, without diagnosed by abdominal...

Systemic lupus erythematosus (SLE) is an autoimmune disease with complex etiology.Genetic aberrations disrupting the immune regulatory mechanisms may initiate development.Recent studies have proved that interferon factor 5 (IRF5) gene important risk for SLE.We aimed to investigate association of rs2004640 polymorphism within IRF5 SLE and Nephritis activity in a sample adult Egyptian population.199 individuals were classified into: group I: included 118 patients who further subdivided into 57...

Objective The objective of this study was to evaluate the association between serum advanced glycation end products (AGEs) and their soluble receptors assessed on basis carboxymethyllysine (CML) receptor for (sRAGE) presence cardiovascular dysfunction in nondiabetic chronic kidney disease (CKD) patients. Background AGE is involved left ventricular hypertrophy (LVH) myocardial damage, whereas sRAGE attenuates progression heart prevents death diabetic CKD Patients methods Eighty patients were...

Background: Chronic kidney disease (CKD) is a worldwide public health alarming problem. Although both heart and kidneys are separated by quite distance within the body they perform varied functions, there close physiological relationship between them. The diseases in can trigger vice versa. High blood pressure most significant risk factor for development progression of chronic (CKD). Lowering goal to prevent CKD progress. abnormalities cardiac function (e.g., congestive failure) causing,...

Long non-coding RNA (lncRNA) TUG1 acts as a proto-oncogene, allowing the proliferation of tumor cells, and it has been related to inflammation. Therefore, we aimed in this study investigate for first time role gene polymorphism level biomarkers systemic lupus erythematosus (SLE) their link nephritis 145 SLE. A total healthy controls were subjected clinical laboratory evaluation. The disease activity was assessed by SLE index (SLEDAI) score. patients divided into two subgroups according...

Background It has been demonstrated that acute rejection (AR) episodes are major risk factors of renal allograft loss. Still the impact early (EAR) on long-term graft survival is debated. The aim this study was to and late (LAR) survival. Patients methods In retrospective we investigated timing frequency AR in 120 kidney transplant recipients for a 3-years period. were divided into three groups; Group I: No (No-AR), II: Early (EAR), III: Late (LAR). survivals groups associated analyzed....

Background Diabetic kidney disease (DKD) represents the major cause of chronic disease. New biomarkers for early diagnosis DKD are interest. Our objective is to elucidate significance microRNA-192 (miRNA-192) and neutrophil gelatinase-associated lipocalin (NGAL) as predictors diabetic nephropathy in comparison with albuminuria type-2 patients. Patients methods A number 45 persons three groups, group 1: 15 healthy no diabetes mellitus (DM). Group 2: patients diagnosed (T2DM) without...