A5032422316- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- ECG Monitoring and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Cardiac tumors and thrombi
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Frailty in Older Adults
- Healthcare Technology and Patient Monitoring
- COVID-19 and healthcare impacts
- Cardiac electrophysiology and arrhythmias
Hamad Medical Corporation
2020-2025
Mayo Clinic
2015-2025
WinnMed
2015-2025
Weill Cornell Medical College in Qatar
2017-2025
Hamad General Hospital
2019-2023
Mayo Clinic in Arizona
2015-2023
Mayo Clinic in Florida
2015-2022
Cornell University
2012-2017
Johns Hopkins University
2013-2015
Johns Hopkins Medicine
2013-2015
Background: We aim to study the incidence of major complications related procedure defined as in-hospital death, myocardial infarction, stroke, pericardial effusion or tamponade, percutaneous coronary intervention due iatrogenic dissection, unplanned bypass surgery within 72 hours after diagnostic left heart catheterization (LHC; primary end point). Furthermore, all causes death LHC were adjudicated and reported (secondary Methods Results: Diagnostic procedures (aortic angiography; coronary,...
Enhanced macroautophagy/autophagy is recognized as a component of the pathogenesis smoking-induced airway disease. Based on knowledge that enhanced autophagy linked to oxidative stress and DNA damage response, both which are smoking, we used microarray analysis epithelium identify smoking upregulated genes known respond response. This identified OSGIN1 (oxidative induced growth inhibitor 1) significantly by in large small epithelium, an observation confirmed independent cohort, TaqMan PCR...
Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in small airways. Despite progress animal studies, genes their expression pattern involved mucus production secretion human airway epithelium are not well understood. We hypothesized that comparison transcriptomes individuals express high vs low levels MUC5AC, major macromolecular component mucus, could be used as a probe...
Patients with symptomatic severe mitral annular calcification present a therapeutic challenge. Direct transatrial implantation of SAPIEN valve has emerged as an alternative to surgical (MV) replacement for high-risk candidates.This series includes 6 consecutive patients deemed be at high risk standard surgery. All underwent direct balloon-expandable in the position.Mean age was 81 years [3 (50%) female], average Society Thoracic Surgeons score 10.3%. had least New York Heart Association...
Background Chronic kidney disease ( CKD ) remains an independent predictor of cardiovascular morbidity and mortality. complicates referral for percutaneous coronary intervention PCI in non–ST‐segment–elevation myocardial infarction NSTEMI patients because the risk acute injury need dialysis, with American College Cardiology/American Heart Association guidelines underscoring limited data on these patients. Methods Results Using National Inpatient Sample to analyze hospitalizations United...
Abstract Introduction Three‐dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). Methods Eight patients with severe annular calcification (MAC) underwent TMVR. 3D digital models balloon expandable valves were created from pre‐procedure CT scans using dedicated software. Five printed. These assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract...
Background Patients with symptomatic severe aortic stenosis and a history of chest radiation therapy represent complex challenging cohort. It is unknown how transcatheter valve replacement ( TAVR ) compares surgical in this group patients, which was the objective study. Methods Results We retrospectively reviewed all patients who underwent either or at our institution mediastinal (n=55 per group). End points were echocardiographic clinical outcomes in‐hospital, 30 days, 1 year. Inverse...
Abstract Objectives To evaluate the outcomes of transcatheter coronary artery fistula (CAF) closure and to identify anatomic/procedural factors that may impact outcomes. Background Due rarity CAF, reported experience with remains limited anatomic procedural lead unsuccessful closure, complications, or recanalization CAF are unclear. Methods All patients who underwent at Mayo Clinic from 1997 2018 were retrospectively reviewed. characteristics, techniques, clinical/angiographic assessed....
Current research on valvular heart repair has focused tissue-engineered valves (TEHV) because of its potential to grow similarly native valves. Decellularized xenografts are a promising solution; however, host recellularization remains challenging. In this study, decellularized porcine aortic were implanted into the right ventricular outflow tract (RVOT) sheep investigate potential. Porcine valves, with sodium dodecyl sulfate (SDS), sterilized by supercritical carbon dioxide (scCO2) and RVOT...
Abstract Background Racial disparities in cardiovascular care have been extensively investigated. The introduction of transcatheter aortic valve replacement (TAVR) revolutionized the treatment stenosis (AS) last decade. Whether a racial disparity utilization and outcome TAVR exists is unknown. Methods We utilized nationwide inpatient sample (NIS) to compare rates, in‐hospital outcomes Caucasians African American (AA) patients who underwent between August 2011 December 2014. Results A total...
Aims: Sarcopaenia is a prevalent disease of ageing, associated with adverse clinical outcomes. We aimed to compare in-hospital outcomes and overall mortality in sarcopaenic non-sarcopaenic patients undergoing transcatheter aortic valve replacement (TAVR). Methods results: This was retrospective cohort study including 602 who underwent TAVR. defined as skeletal muscle mass index <55.4 cm2/m2 males <38.9 females obtained through pre-TAVR CT scan. Mortality, length hospital stay, ICU admission,...
Background We tested whether biologic age, as estimated by deficits, functional impairments, or Age‐Gap their combination, provide improved estimation of cause‐specific death compared with chronological age. Methods Cardiovascular and noncardiovascular were prospectively collected in 535 patients aged ≥55 years undergoing percutaneous coronary interventions between August 1, 2014, March 31, 2018. was calculated the difference age artificial intelligence ECG using a convolutional neural...