A5041900895- Congenital Diaphragmatic Hernia Studies
- Pediatric Urology and Nephrology Studies
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Respiratory Health Research
- Urological Disorders and Treatments
- Cardiac Arrest and Resuscitation
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Congenital Anomalies and Fetal Surgery
- COVID-19 and healthcare impacts
- Tissue Engineering and Regenerative Medicine
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Hernia repair and management
- Diversity and Career in Medicine
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Surgical Simulation and Training
- Diverticular Disease and Complications
- Pediatric Pain Management Techniques
- IgG4-Related and Inflammatory Diseases
- Ureteral procedures and complications
- Appendicitis Diagnosis and Management
Ospedale Regina Margherita
2021-2025
University of Padua
2019-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022-2024
University College London
2018-2023
Great Ormond Street Hospital
2023
Ospedale Sant'Anna
2023
Veneto Institute of Molecular Medicine
2020
University of Palermo
2015-2019
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2016-2018
Pavia nel Cuore
2014-2017
Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture. Here, we envisage that use extracellular matrix (ECM) hydrogels derived from decellularized tissues (DT) can provide an environment capable directing cell growth. These gels possess biochemical signature tissue-specific ECM translation....
COVID-19 typically manifests as a respiratory illness, but several clinical reports have described gastrointestinal symptoms. This is particularly true in children whom symptoms are frequent and viral shedding outlasts clearance from the system. These observations raise question of whether virus can replicate within stomach. Here we generate gastric organoids fetal, pediatric, adult biopsies vitro models SARS-CoV-2 infection. To facilitate infection, induce reverse polarity organoids. We...
Postoperative effect of music listening has not been established in pediatric age. Response on postoperative distress and pain day care surgery evaluated. Forty-two children were enrolled. Patients randomly assigned to the music-group (music intervention during awakening period) or non-music group (standard care). Slow fast classical pauses recorded played via ambient speakers. Heart rate, blood pressure, oxygen saturation, glucose cortisol levels, faces scale Face, Legs, Activity, Cry,...
Transition of care (TOC; from childhood into adulthood) patients with anorectal malformations (ARM) and Hirschsprung disease (HD) ensures continuation for these patients. The aim this international study was to assess the current status TOC adult (AC) programs ARM HD.A survey developed by members EUPSA, ERN eUROGEN, ERNICA, including patient representatives (ePAGs), comprising four domains: general information, questions about transition adulthood, disease-specific regarding AC programs....
Nonrespiratory conditions related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been largely described. Ileocolic intussusception has reported in association with SARS-CoV-2 infection 10 children, raising the possibility of an etiopathologic role for virus, but none these cases documented tissue pathology that would supported intestinal inflammation. We report patients who were treated at different pediatric tertiary centers Europe and provide evidence...
Background: Congenital h-type tracheoesophageal fistula (H-TEF) without esophageal atresia (EA) represents about 4% of congenital anomalies. The diagnosis is challenging, and surgery considered curative. aim was to report a national survey on the diagnosis, management, outcome patients with H-TEF. Methods: Following approval Italian Society Pediatric Surgery, sent all Surgery Units retrospectively collect H-TEF treated in period 2010–2022. Descriptive analysis performed, results are given as...
Apple peel atresia (APA) is a rare and severe form of intestinal atresia, but little known on long-term outcomes. We compared outcomes apple-peel based different surgical approaches. retrospective review from two institutions APA-resected APA-preserved patients. Demographics, operative details, postoperative courses were analyzed. Of the 16 APA neonates, 10 (62.5%) in 6 (37.5%) groups. Early complications occurred 7 patients (43.75%) including vomiting, infection, occlusion, anastomotic...
The Severe Acute Respiratory Syndrome virus (SARS-CoV-2) had a great impact in the worldwide population. Because of personal protective equipment (PPE), children have not been exposed to commonly circulating respiratory viruses, with an effect on pneumonia disease spreading. aim our study was evaluate different distribution invasive procedures for complicated pre, intra and post pandemic period. We conducted retrospective analysis who underwent pneumonia, focusing winter season. Three...
The postnatal management of pulmonary malformations is still controversial, especially in terms indication and timing for surgery. Despite being rare, neonatal lung tumors should be included the differential diagnosis case abnormalities. aim this study to evaluate if absence antenatal findings considered a risk factor malignancy patients with abnormalities at imaging. medical records undergone surgery our hospital, over period 5 years (2017-2021), were retrospectively reviewed. Histological...
Congenital colonic stenosis is a rare pediatric condition. Since 1968, only 16 cases have been reported in the literature. To authors' knowledge, multiple congenital has not previously We report case of 2-month-old male, presented at our Neonatal Intensive Care Unit with suspicion intestinal malrotation. Clinical examination revealed persistent abdominal distension. During enema examination, contrast medium appeared to fill lumen colon up three stenotic segments and could proceed further....
Purpose: The study was designed to assess the utility and controversies surrounding usage of 5-mm instruments in paediatric robotic surgery. Adequate, delicate for surgery very narrow spaces are still lacking. Material methods: Thirty children underwent elective abdominal Working sites, assembly operative time, hospital stay, advantages, complications shortcomings reported. Results: Interventions were performed following anatomical sites: 11 upper abdominal, nine pelvic, ten renal...
Visceral solitary myofibromas are uncommon in childhood. We report a case of asymptomatic visceral myofibroma the bladder trigone occurring 3-month-old boy. Once malignancies were ruled out by cystoscopy, radical excision was performed order to avoid any potential impairment dynamic. Postoperative course uneventful and patient discharged on day 3 after surgery. After 36 months follow-up, is toilet-trained remains well; function normal.
Conditions leading to reduced gastric volume are difficult manage and associated poor quality-of-life. Stomach augmentation using a tissue-engineered stomach is potential solution restore adequate physiology food reservoir. Aim of this study was evaluate the decellularisation whole rat detergent-enzymatic protocol.Stomachs harvested from rats were decellularised through luminal vascular cannulation 24-h treatment completely characterized by appropriate staining, DNA Extracellular matrix...
Tracheal occlusion (TO) stimulates lung growth in fetuses affected with congenital diaphragmatic hernia (CDH) although the processes involved maturation still remain unknown. The objective of this study was to evaluate metabolomic profile amniotic fluid (AF) following TO fetal lamb model order obtain an indirect view mechanisms pulmonary reversal hypoplasia and biochemical maturity response TO. Liquid Chromatography Mass Spectrometry performed on AF samples at: age I (70 days' gestation); II...