A5019822523- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Histiocytic Disorders and Treatments
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Cutaneous lymphoproliferative disorders research
- Parvovirus B19 Infection Studies
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Fungal Infections and Studies
- Acute Lymphoblastic Leukemia research
- Cancer Risks and Factors
- Chemotherapy-induced organ toxicity mitigation
- Renal cell carcinoma treatment
- Soft tissue tumor case studies
- Vascular Malformations Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- CNS Lymphoma Diagnosis and Treatment
- Iron Metabolism and Disorders
- COVID-19 and healthcare impacts
University of Health Science
2019-2025
Sağlık Bilimleri Üniversitesi
2018-2025
University of Health Sciences
2019-2025
Ministry of Health
2013-2024
Memorial Ankara Hospital
2014-2023
City Hospital
2021-2023
Bilkent University
2023
Ankara Bilkent City Hospital
2023
Palmetto Hematology Oncology
2015-2021
Ankara Mevki Asker Hastanesi
2021
Purpose: 18 F-FDG PET/CT plays a crucial role in the evaluation and management of pediatric classic Hodgkin lymphoma (cHL). In addition to visual assessment, quantitative parameters also have prognostic value. This study aimed investigate significance PET parameters, with particular focus on changes observed these after 2 cycles chemotherapy, cHL patients. Patients Methods: The was designed as single-center, retrospective. A total 198 patients who underwent baseline post-2-cycle chemotherapy...
Genistein sensitizes cancer cells to chemotherapy and radiation by modulating cell survival pathways. At the same time, genistein's antioxidant anti-inflammatory effects may protect normal tissues from adverse of radiation, which are largely due oxygen-free radicals inflammation. We conducted a small pilot study with soy isoflavone mixture containing 8 mg genistein in children receiving and/or investigate potential toxicity preventive effect. monitored clinical laboratory parameters who...
Cancer care is progressively became as a significant worldwide challenge. Wars can cause destructions and delays in cancer diagnosis treatment of displaced people. cure rates need to be improved indefensible populations such refugees. In this study, we purposed highlight the clinical peculiarities outcomes refugee children with our hospital. Our purpose was present findings contribute improve health for these children. Seventy one pediatric patients admitted oncology hematology units...
Chronic lymphocytic leukemia/lymphoma (CLL) is an extremely rare disease during childhood. We report a 16‐year‐old female who presented with lymphadenopathies and she was diagnosed as T cell lymphoblastic lymphoma. Her chemotherapy response minimal clinical findings were unusual. Therefore, her biopsy specimen re‐examined diagnosis changed to CLL. Chemotherapy protocol including fludarabine, cyclophosphamide, rituximab administrated good observed. In our patient deletion at 1q21.2 region...
Thalassemia major (TM) is a chronic disease requiring regular transfusions that may result in generalized iron loading, such as the heart, liver, endocrine organs, and lungs. We aimed to determine pulmonary function abnormalities children with TM our center.In this study, tests (PFTs) of 49 patients who received blood transfusion had no history respiratory were evaluated. The relationship between PFTs age, body surface area, pretransfusional hemoglobin, serum ferritin was evaluated.Among...
Wilms tumor (WT) is the most common malignant renal in childhood. Approximately 5-7% of WT patients present with bilateral disease, either synchronously or metachronously. Bilateral usually occurs younger children and more often girls. Management a child very challenging. In contrast to unilateral WT, there has not been uniform agreement about therapeutic strategy management WT. As surgery critical component treatment aim achieve high cure rate while maintaining adequate long-term function...
In this study, clinical characteristics, treatment modalities and outcome of patients diagnosed with bladder/prostate rhabdomyosarcoma (BP RMS) were evaluated retrospectively. Files 8 children BP RMS treated between 2004-2014 reviewed for outcome. Seven males one female 2004-2014. Median age was 33.5 months (range, 2 to 176 months). At presentation the main symptoms hematuria in 5 patients, constipation, oliguria prolonged jaundice 1 patient each. All non-metastatic only had an embryonal...
In the etiology of childhood cancers, many genetic and environmental factors play a role. One these could be cigarette smoking, main source tobacco smoke exposure children is parental smoking. However, establishing causal relationship between smoking cancers has proven challenging due to difficulties in accurately detecting METHODS: To address this issue, we used hair cotinine analysis questionnaire get information about exposures pediatric cancer patients healthy children. A total 104 99...
Background: Nuclear protein of the testis (NUT) midline carcinoma is genetically defined by rearrangement NUT or immunohistochemical expression NUT. Findings: A 6-year old child had a lung. Despite aggressive therapy, died. Conclusion: carcinoma, which can be diagnosed immunohistochemically, remains an tumor.
Adequate nutrient intake should be provided for the cure of children diagnosed with cancer. The aim this study was to evaluate serum trace elements and vitamins cancer at diagnosis during treatment. Children newly who were admitted our center evaluated selenium, iron, ferritin, C-reactive protein, vitamin B12, folate, 25-OH D levels presentation, third sixth months Forty-two (male/female: 15/27) a median age 8 years (range, 2 17) included in study. Mean iron within normal ranges, but...
Emir S, Hacısalihoğlu Ş, Özyörük D, Kaçar Erdem A, Karakuş E. Squamous cell carcinoma associated with Xeroderma pigmentosum: an unusual presentation a tremendously huge mass over the face and paraneoplastic hypercalcemia-hyperleukocytosis. Turk J Pediatr 2017; 59: 711-714. pigmentosum (XP) is rare autosomal recessive disorder that results from genetic defects in DNA repair manifests marked hypersensivity to ultraviolet rays. Children X-P are at high risk of developing skin cancers. On other...
Congenital portosystemic shunts are rare vascular malformations that lead to several complications including liver tumors, pulmonary hypertension, and metabolic encephalopathy. We describe a case of 17-year-old girl with an extrahepatic shunt presenting recurrent syncope episodes mass mimicking hepatocellulary carcinoma.
High cumulative doses of anthracyclines (300-500 mg/m(2)) used in the treatment children with cancer may result cardiotoxicity, a major long-term adverse effect that limits clinical usefulness this class chemotherapeutic agents. We assessed anthracycline-induced cardiotoxicity by measuring Pro-BNP levels and echocardiographic (ECHO) findings investigated potential protective selenium (Se) supplementation group pediatric patients. Plasma level was measured, ECHO performed 67 patients (45...
Abstract Background: It has been estimated that rare tumor rate is about 15% of all childhood cancer in United States. According to Turkish Pediatric Oncology Group (TPOG) datas, 8889 children were diagnosed between 2002 and 2008 our country 3.7% them as tumors. Aim: To investigate the frequency clinical features tumors pediatric oncology center. Materials Methods: A total 43 cases have 574 patients yaer 2012 reviewed retrospectively. All definitive diagnosis established by histopathological...
Cisplatin is one of the effective chemotherapeutic agents widely used for many tumor types in children. The most serious complications cisplatin overdose are nephrotoxicity and ototoxicity. It may lead to life-threatening even death. We report a 13-year-old female patient with osteosarcoma who received massive mistakenly. She was given 120 mg/m2/day consecutive two days, instead day (total 240 mg/m2) due prescription error. After 12 hours, her level measured as 8,500 ng/ml (normal:...
Primary immune deficiencies are a group of heterogenous genetic disorders characterized by frequent infections, autoimmunity and malignancy. In this study, we aimed to evaluate clinical characteristics, outcomes children with malignancy developed on background primary immunodeficiency compare survival rates patients between malignant lymphoma without from tertiary oncology center in developing country. A total 23 were evaluated retrospectively. 26 malignancies (first or second) determined....
As a result of mutations in TSC1 (9q34) and TSC2 (16p13.3) tumor supressor genes, the mammalian target rapamycin (mTor) signaling pathway is overactivated patients with tuberous sclerosis. Abnormal cell proliferation differentiation responsible for growth several different tumors. The aim this study was to review tumors our sclerosis.Thirty-six sclerosis were reviewed retrospectively terms age, sex, family history, clinical findings, presence tumors, treatments.Our included 36 (18/18:M/F)...